Reactive nitrogen and oxygen intermediates and bacterial defenses: Unusual adaptations in Mycobacterium tuberculosis

Antioxidants and Redox Signaling

Volumn 4, Issue 1, 2002, Pages 141-159

  Zahrt, Thomas C ^a   Deretic, Vojo ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITROGEN DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ADAPTATION; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIAL SURVIVAL; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; BIOSYNTHESIS; DEFENSE MECHANISM; ENTEROBACTERIACEAE; ENZYME ACTIVATION; HOST RESISTANCE; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NITROSATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALS; ANTITUBERCULAR AGENTS; HUMANS; MICE; MODELS, BIOLOGICAL; MODELS, GENETIC; MYCOBACTERIUM TUBERCULOSIS; OXIDATIVE STRESS; OXYGEN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; TUBERCULOSIS;

BACTERIA (MICROORGANISMS); ENTEROBACTERIACEAE; MYCOBACTERIUM; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 0036200214     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/152308602753625924     Document Type: Article

References (142)

1. Comparison of the roles of reactive oxygen and nitrogen intermediates in the host response to Mycobacterium tuberculosis using transgenic mice
2. Effector mechanisms involved in cytokine-mediated bacteriostasis of Mycobacterium avium infections in murine macrophages
3. An iron-regulated alkyl hydroperoxide reductase (AhpC) confers aerotolerance and oxidative stress resistance to the microaerophilic pathogen Campylobacter jejuni
4. inhA a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis
5. Antibacterial agents that inhibit two-component signal transduction systems
6. Nicotinamide-adenine dinucleotide in tubercle bacilli exposed to isoniazid
7. TNF-α controls intracellular mycobacterial growth by both inducible nitric oxide synthase-dependent and inducible nitric oxide synthase-independent pathways
8. Tuberculosis: Commentary on a reemergent killer
9. Peroxynitrite reductase activity of bacterial peroxiredoxins
10. Bacillus subtilis contains multiple Fur homologues: Identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors
11. Recombination-deficient mutants of Salmonella typhimurium are avirulent and sensitive to the oxidative burst of macrophages
12. Free hydroxyl radicals are formed on reaction between the neutrophil-derived species superoxide anion and hypochlorous acid
13. Immune mechanisms of protection
14. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages
15. Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis
16. Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates
17. Structural basis of the redox switch in the OxyR transcription factor
18. OxyR a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium is homologous to a family of bacterial regulatory proteins
19. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
20. Massive gene decay in the leprosy bacillus
21. phox-/− mice
22. Antimicrobial properties of nitric oxide
23. Homocysteine antagonism of nitric oxide-related cytostasis in Salmonella typhimurium
24. Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase
25. Interferon-gamma-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates
26. Mycobacterium tuberculosis phagosome
27. Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: Implications for sensitivity to isoniazid
28. The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid
29. Loss of oxyR in Mycobacterium tuberculosis
30. Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: Characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis
31. Fur positive regulation of iron superoxide dismutase in Escherichia coli: Functional analysis of the sodB promoter
32. Hypochlorous acid stress in Escherichia coli: Resistance DNA damage and comparison with hydrogen peroxide stress
33. Interdependence of mycobacterial iron regulation oxidative-stress response and isoniazid resistance
34. An ideR mutant of Mycobacterium smegmatis has derepressed siderophore production and an altered oxidative-stress response
35. Consensus statement. Global burden of tuberculosis: Estimated incidence prevalence and mortality by country
36. A novel antioxidant gene from Mycobacterium tuberculosis
37. Perspectives series: Host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity
38. The transcriptional regulator SoxS is required for resistance of Salmonella typhimurium to paraquat but not for virulence in mice
39. Bacterial copper- and zinc-cofactored superoxide dismutase contributes to the pathogenesis of systemic salmonellosis
40. The role of reactive oxygen species (ROS) in the effector mechanisms of human antimycobacterial immunity
41. Effects of aminoguanidine on latent murine tuberculosis
42. Assessment of chlorination by human neutrophils
43. Identification of the ahp operon of Salmonella typhimurium as a macrophage-induced locus
44. Response of Mycobacterium tuberculosis to reactive oxygen and nitrogen intermediates
45. SoxR a [2Fe-2S] transcription factor is active only in its oxidized form
46. Regulation of macrophage function by interferon-gamma. Somatic cell genetic approaches in murine macrophage cell lines to mechanisms of growth inhibition the oxidative burst and expression of the chronic granulomatous disease gene
47. Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction
48. A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress
49. Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli
50. Regulation of the furA and catC operon encoding a ferric uptake regulator homologue and catalase-peroxidase respectively in Streptomyces coelicolor A 3(2)
51. An operon containing fumC and sodA encoding fumarase C and manganese superoxide dismutase is controlled by the ferric uptake regulator in Pseudomonas aeruginosa: Fur mutants produce elevated alginate levels
52. Nitrosative stress: Activation of the transcription factor OxyR
53. Nitrosative stress: Metabolic pathway involving the flavohemoglobin
54. Mechanisms of chlorine oxidation of hydrogen peroxide
55. Missense mutations in the catalase-peroxidase gene katG are associated with isoniazid resistance in Mycobacterium tuberculosis
56. The molecular basis of isoniazid resistance in Mycobacterium tuberculosis
57. Hydrogen peroxide oxidation by chlorine compounds. Reaction dynamics and singlet oxygen formation
58. DNA damage and oxygen radical toxicity
59. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
60. The p47phox mouse knock-out model of chronic granulomatous disease
61. Studies on the mechanism of action of isoniazid and ethionamide in the chemotherapy of tuberculosis
62. Antigenic role of stress-induced catalase of Salmonella typhimurium in cell-mediated immunity
63. Metabolism of nicotinamide adenine dinucleotide in human and bovine strains of Mycobacterium tuberculosis
64. Singlet molecular oxygen evolution upon simple acidification of aqueous hypochlorite: Application to studies on the deleterious health effects of chlorinated drinking water
65. Singlet molecular oxygen in the Haber-Weiss reaction
66. Myeloperoxidase-halide-hydrogen peroxide antibacterial system
67. Identification of macrophage and stress-induced proteins of Mycobacterium tuberculosis
68. Mechanism of regulation of 8-hydroxyguanine endonuclease by oxidative stress: Roles of FNR ArcA and Fur
69. Expression of katG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs
70. Glucose 6-phosphate dehydrogenase is required for Salmonella typhimurium virulence and resistance to reactive oxygen and nitrogen intermediates
71. Identification of nitric oxide synthase as a protective locus against tuberculosis
72. Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor
73. Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro
74. InhA a target of the antituberculous drug isoniazid is involved in a mycobacterial fatty acid elongation system FAS-II
75. Mapping of Mycobacterium tuberculosis katG promoters and their differential expression in infected macrophages
76. Inhibition of a Mycobacterium tuberculosis betaketoacyl ACP synthase by isoniazid
77. Sterilization of tubercle bacilli by isonicotinic acid hydrazide and the incidence of variants resistant to the drug in vitro
78. NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis
79. Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: Possible role for limiting pathology
80. Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins
81. Defining the requirements for immunological control of mycobacterial infections
82. Nucleotide sequence of the Mycobacterium leprae katG region
83. Nitric oxide as a secretory product of mammalian cells
84. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
85. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis
86. Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase inducible nitric oxide synthase or both
87. Control of Escherichia coli superoxide dismutase (sodA and sodB) genes by the ferric uptake regulation (fur) locus
88. Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages
89. Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosis
90. Drug-resistant strains of Mycobacterium tuberculosis exhibit a range of virulence for mice
91. Mouse model of tuberculosis
92. Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli
93. Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum
94. Comparison of the sensitivities of Salmonella typhimurium oxyR and katG mutants to killing by human neutrophils
95. Mechanisms of latency in Mycobacterium tuberculosis
96. Mouse model of X-linked chronic granulomatous disease an inherited defect in phagocyte superoxide production
97. Regulation of catalase-peroxidase (KatG) expression isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis
98. Susceptibility of a panel of virulent strains of Mycobacterium tuberculosis to reactive nitrogen intermediates
99. The pathogenesis of tuberculosis
100. Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid
101. Disorders of phagocyte function
102. Molecular mechanisms of isoniazid resistance in Mycobacterium tuberculosis and Mycobacterium bovis
103. Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis
104. noxR3 a novel gene from Mycobacterium tuberculosis protects Salmonella typhimurium from nitrosative and oxidative stress
105. The structure and function of the isoniazid target in M. tuberculosis
106. Phagocytic killing of microorganisms by radical processes: Consequences of the reaction of hydroxyl radicals with chloride yielding chlorine atoms
107. Recombinant natural killer enhancing factor augments natural killer cytotoxicity
108. Mode of action and quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type
109. Identification of a natural killer enhancing factor (NKEF) from human erythroid cells
110. Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria
111. Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis
112. AhpC oxidative stress and drug resistance in Mycobacterium tuberculosis
113. Reactive nitrogen intermediates and the pathogenesis of Salmonella and mycobacteria
114. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase
115. Enzymatic and nonenzymatic superoxide-generating reactions of isoniazid
116. Evidence for the generation of active oxygen by isoniazid treatment of extracts of Mycobacterium tuberculosis H37Ra
117. Silencing of oxidative stress response in Mycobacterium tuberculosis: Expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation
118. Deletion of the putative antioxidant noxR1 does not alter the virulence of Mycobacterium tuberculosis H37Rv
119. Oxidative stress
120. Oxidative stress
121. Iron and oxygen regulation of Escherichia coli MnSOD expression: Competition between the global regulators Fur and ArcA for binding to DNA
122. The Salmonella typhimurium AhpC polypeptide is not essential for virulence in BALB/c mice but is recognized as an antigen during infection
123. A commercial preparation of catalase inhibits nitric oxide production by activated murine macrophages: Role of arginase
124. Differential induction of heat shock SOS and oxidation stress regulons and accumulation of nucleotides in Escherichia coli
125. Campylobacter jejuni contains two fur homologs: Characterization of iron-responsive regulation of peroxide stress defense genes by the PerR repressor
126. Iron-responsive gene regulation in a Campylobacter jejuni fur mutant
127. Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase
128. Killing of Mycobacterium microti by immunologically activated macrophages
129. Escherichia coli proteins inducible by oxidative stress mediated by the superoxide radical
130. Dormancy of Mycobacterium tuberculosis and latency of disease
131. Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: A review
132. Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization
133. Antisense RNA to ahpC an oxidative stress defence gene involved in isoniazid resistance indicates that AhpC of Mycobacterium bovis has virulence properties
134. ahpC a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex
135. Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG
136. Molecular mechanisms of isoniazid: A drug at the front line of tuberculosis control
137. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
138. Molecular basis for the exquisite sensitivity of Mycobacterium to isoniazid
139. OxyR and SoxRS regulation of fur
140. The mycelium-associated Streptomyces reticuli catalase-peroxidase its gene and regulation by FurS