Silencing of oxidative stress response in Mycobacterium tuberculosis: Expression patterns of ahpC in virulent and avirulent strains and effect of ahpC inactivation

Infection and Immunity

Volumn 69, Issue 10, 2001, Pages 5967-5973

  Springer, B ^a   Master, S ^a   Sander, P ^a   Zahrt, T ^a   McFalone, M ^a   Song, J ^a   Papavinasasundaram, K G ^a   Colston, M J ^a   Boettger, E ^a   Deretic, V ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CUMENE HYDROPEROXIDE; GREEN FLUORESCENT PROTEIN; HYDROGEN PEROXIDE; OXIDOREDUCTASE; PEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIAL VIRULENCE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE INACTIVATION; GENE REPRESSION; HOST CELL; IN VITRO STUDY; MACROPHAGE; MOUSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPORTER GENE; TUBERCULOSIS;

ANIMALS; ANTIOXIDANTS; FEMALE; GENE EXPRESSION PROFILING; HYDROGEN PEROXIDE; MICE; MICE, INBRED BALB C; MYCOBACTERIUM TUBERCULOSIS; OXIDATIVE STRESS; PEROXIDASES; RECOMBINATION, GENETIC; VIRULENCE;

EID: 0034826633     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.10.5967-5973.2001     Document Type: Article

References (51)

1. Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival
2. Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status
3. Comparative genomics of BCG vaccines by whole-genome DNA microarray
4. Peroxynitrite reductase activity of bacterial peroxiredoxins
5. Interaction of Bacillus subtilis Fur (ferric uptake repressor) with the dhb operator in vitro and in vivo
6. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages
7. Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates
8. Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium
9. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
10. Massive gene decay in the leprosy bacillus
11. phox-/- mice
12. The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid
13. Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: Implications for sensitivity to isoniazid
14. Loss of oxyR in Mycobacterium tuberculosis
15. Interactions of OxyR with the promoter region of the oxyR and ahpC genes from Mycobacterium leprae and Mycobacterium tuberculosis
16. Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages
17. Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: Characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis
18. A novel antioxidant gene from Mycobacterium tuberculosis
19. A coat protein on phagosomes involved in the intracellular survival of mycobacteria
20. Stimulation or inhibition of the respiratory burst in cultured macrophages in a mycobacterium model: Initial stimulation is followed by inhibition after phagocytosis
21. Nitrosative stress: Activation of the transcription factor OxyR
22. Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis
23. The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis
24. Genetic systems for mycobacteria
25. An alkyl hydroperoxide reductase from Salmonella typhimurium involved in the defense of DNA against oxidative damage. Purification and properties
26. Identification of nitric oxide synthase as a protective locus against tuberculosis
27. Nucleotide sequence of the Mycobacterium leprae katG region
28. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis
29. Amphibacillus xylanus NADH oxidase and Salmonella typhimurium alkyl-hydroperoxide reductase flavoprotein components show extremely high scavenging activity for both alkyl hydroperoxide and hydrogen peroxide in the presence of S. typhimurium alkyl-hydroperoxide reductase 22-kDa protein component
30. Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages
31. Mouse model of tuberculosis
32. Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum
33. Mechanisms of latency in Mycobacterium tuberculosis
34. Molecular definition and identification of new proteins of Mycobacterium leprae
35. noxR3, a novel gene from Mycobacterium tuberculosis, protects Salmonella typhimurium from nitrosative and oxidative stress
36. Gene replacement in Mycobacterium smegmatis using a dominant negative selectable marker
37. +: A dominant selectable marker for gene replacement in mycobacteria
38. Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis
39. Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria
40. The neglected global tuberculosis problem: A report of the 1992 World Congress on Tuberculosis
41. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase
42. The Salmonella typhimurium AhpC polypeptide is not essential for virulence in BALB/c mice but is recognized as an antigen during infection
43. Effects of cytokines on mycobacterial phagosome maturation
44. Killing of Mycobacterium microti by immunologically activated macrophages
45. Dynamics of submerged growth of Mycobacterium tuberculosis under aerobic and microaerophilic conditions
46. Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties
47. Production of avirulent Mycobacterium bovis strains by illegitimate recombination with deoxyribonucleic acid fragments containing an interrupted ahpC gene
48. ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex
49. Cloning and expression of the gene for the Avi-3 antigen of Mycobacterium avium and mapping of its epitopes
50. Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG
51. Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid