Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis

Molecular Microbiology

Volumn 40, Issue 4, 2001, Pages 879-889

  Pym, Alexander S ^a,b   Domenech, Pilar ^a   Honoré, Nadine ^a   Song, Jian ^c   Deretic, Vojo ^c   Cole, Stewart T ^a  

^a INSTITUT PASTEUR   (France)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; ISONIAZID; PEROXIDASE; SIDEROPHORE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; ENZYME SYNTHESIS; GENE EXPRESSION REGULATION; MYCOBACTERIUM BOVIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; START CODON;

ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; DRUG RESISTANCE, MICROBIAL; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; ISONIAZID; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; OPERON; PEROXIDASES; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; SIDEROPHORES; SUPEROXIDE DISMUTASE; TUBERCULOSIS; VIRULENCE;

ACTINOBACTERIA (CLASS); ANIMALIA; BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0035013527     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02427.x     Document Type: Article

References (44)

1. Comparative genomics of BCG vaccines by whole-genome DNA microarray
2. Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene
3. Bacillus subtilis contains multiple Fur homologues: Identification of the iron uptake (Fur) and peroxide regulon (PerR) repressors
4. A parallel intraphagosomal survival strategy shared by Mycobacterium tuberculosis and Salmonella enterica
5. Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis
6. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
7. Mutation of the principal sigma factor causes loss of virulence in a strain of the Mycobacterium tuberculosis complex
8. Site-directed mutagenesis of the ferric uptake regulation gene of Escherichia coli
9. Gene expression in mycobacteria: Transcriptional fusions based on xy/E and analysis of the promoter region of the response regulator mtrA from Mycobacterium tuberculosis
10. Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: Implications for sensitivity to isoniazid
11. Iron acquisition and metabolism by mycobacteria
12. The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages
13. Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: Characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis
14. An ideR mutant of Mycobacterium smegmatis has derepressed siderophore production and an altered oxidative-stress response
15. Opening the iron box: Transcriptional metalloregulation by the Fur protein
16. Identification of genes involved in the sequestration of iron in mycobacteria: The ferric exochelin biosynthetic and uptake pathways
17. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis
18. Determinants of mycobacterial gene expression
19. The application of bacterial luciferase as a reporter gene in mycobacteria
20. Regulation of the furA and catC operon, encoding a ferric uptake regulator homologue and catalase-peroxidase, respectively, in Streptomyces coelicolor A3(2)
21. Isolation and characterization of isoniazid-resistant mutants of Mycobacterium smegmatis and M. aurum
22. Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: A molecular study
23. Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis
24. Effects of over-expression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis
25. SirR, a novel iron-dependent repressor in Staphylococcus epidermidis
26. Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis
27. Expression of katG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs
28. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
29. Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro
30. Isoniazid-resistance and catalase activities of tubercle bacilli. A preliminary report
31. Some observations on the pathogenicity of isoniazid-resistant variants of tubercle bacilli
32. Characterization of the catalase-peroxidase gene (katG) and inhA locus in isoniazid-resistant and -susceptible strains of Mycobacterium tuberculosis by automated DNA sequencing: Restricted array of mutations associated with drug resistance
33. The DNA-binding characteristics of the Streptomyces reticuli regulator FurS depend on the redox state of its cysteine residues
34. Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum
35. Genetic advances for studying Mycobacterium tuberculosis pathogenicity
36. Site-directed mutagenesis of the katG gene of Mycobacterium tuberculosis: Effects on catalase-peroxidase activities and isoniazid resistance
37. Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis
38. Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria
39. Analysis of the oxyR-ahpC region in isoniazid-resistant and -susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities
40. Campylobacter jejuni contains two fur homologs: Characterization of iron-responsive regulation of peroxide stress defense genes by the PerR repressor
41. Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis
42. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
43. Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations
44. The mycelium-associated Streptomyces reticuli catalase-peroxidase, its gene and regulation by FurS