Antibacterial agents that inhibit two-component signal transduction systems

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 9, 1998, Pages 5317-5322

  Barrett, J F ^a   Goldschmidt, R M ^a   Lawrence, L E ^a   Foleno, B ^a   Chen, R ^a   Demers, J P ^a   Johnson, S ^a   Kanojia, R ^a   Fernandez, J ^a   Bernstein, J ^a   Licata, L ^a   Donetz, A ^a   Huang, S ^a   Hlasta, D J ^a   Macielag, M J ^a   Ohemeng, K ^a,c   Frechette, R ^a   Frosco, M B ^a   Klaubert, D H ^a   Whiteley, J M ^b   Wang, L ^b   Hoch, J A ^b   more..

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 [4 (2 TRITYLETHOXY)PHENYL]ETHYL]GUANIDINE; ANTIINFECTIVE AGENT; CIPROFLOXACIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; METICILLIN; PROTEIN KINASE; QUINOLONE DERIVATIVE; TYRAMINE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL THERAPY; ARTICLE; AUTOPHOSPHORYLATION; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; GRAM POSITIVE BACTERIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; GRAM-POSITIVE BACTERIA; GUANIDINES; PHOSPHORYLATION; PROTEIN KINASES; SIGNAL TRANSDUCTION; TRITYL COMPOUNDS;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 13144276275     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.9.5317     Document Type: Article

References (44)

1. Chu, D. T., Plattner, J. J. & Katz, L. (1996) J. Med. Chem. 39, 3853-3874.
2. Eliopoulos, G. M., Wennersten, C. B., Gold, H. S. & Moellering, R. C. (1996) Antimicrob. Agents Chemother. 40, 1745-1747.
3. Zurenko, G. E., Yagi, B. H., Schaadt, R. D., Allison, J. W., Kilburn, J. O., Glickman, S. E., Hutchinson, D. K., Barbachyn, M. R. & Brickner, S. J. (1996) Antimicrob. Agents Chemother. 40, 839-845.
4. Mason, E. O., Lamberth, L. B. & Kaplan, S. L. (1996) Antimicrob. Agents Chemother. 40, 1039-1040.
5. Brickner, S. J., Hutchinson, D. K., Barbachyn, M. R., Manninen, P. R., Ulanowicz, D. A., Garmon, S. A., Grega, K. C., Hendges, S. K., Toops, D. S., Ford, C. W., et al. (1996) J. Med. Chem. 39, 673-679.
6. Sum, P.-E., Lee, V. J., Testa, R. T., Hlavka, J. J., Ellestad, G. A., Bloom, J. D., Gluzman, Y. & Tally, F. P. (1994) J. Med. Chem. 37, 184-188.
7. Tally, F. T., Ellestad, G. A. & Testa, R. T. (1995) J. Antimicrob. Chemother. 35, 449-452.
8. Weiss, W. J., Jacobus, N. V., Petersen, P. J. & Testa, R. T. (1995) J. Antimicrob. Chemother. 36, 225-230.
9. Onishi, H. R., Pelak, B. A., Gerckens, L. S., Silver, L. L., Kahan, F. M., Chen, M., Patchett, A. A. & Galloway, S. M. (1996) Science 274, 980-982.
10. Miller, J. F., Mekalanos, J. J. & Falkow, S. (1989) Science 243, 916-922.
11. Fields, P. I., Groisman, E. A. & Heffron, F. (1989) Science 243, 1059-1062.
12. Alpuche-Aranda, C. M., Swanson, J. A., Loomis, W. P. & Miller, S. I. (1992) Proc. Natl. Acad. Sci. USA 89, 10079-10083.
13. García-Véscovi, E., Soncini, F. C. & Groisman, E. A. (1996) Cell 84, 165-174.
14. Stock, J. B., Ninfa, A. J. & Stock, A. M. (1989) Microbiol. Rev. 53, 450-490.
15. Parkinson, J. S. & Kofoid, E. C. (1992) Ann. Rev. Genet. 26, 71-112.
16. Maeda, T., Wurgler-Murphy, S. M. & Saito, H. (1994) Nature (London) 369, 242-245.
17. Ota, I. M. & Varshavsky, A. (1993) Science 262, 566-569.
18. Posas, F., Wurgler-Murphy, S. M., Maeda, T., Witten, E. A., Thai, T. C. & Saito, J. (1996) Cell 86, 865-875.
19. Alex, L. A., Borkovich, K. A. & Simon, M. I. (1996) Proc. Natl. Acad. Sci. USA 93, 3416-3421.
20. Chang, C., Kwok, S. F., Bleecker, A. B. & Meyerowitz, E. M. (1993) Science 262, 539-544.
21. Perego, M., Hanstein, C. G., Welsh, K. M., Djavakhishvili, T., Glaser, P. & Hoch, J. A. (1994) Cell 79, 1047-1055.
22. Dziejman, M. & Mekalanos, J. J. (1995) in Two-Component , Signal Transduction, eds. Hoch, J. A. & Silhavy, T. J. (Am. Soc. Microbiol., Washington, DC), pp. 305-317.
23. Groisman, E. A. & Heffron, F. (1995) in Two-Component Signal Transduction, eds. Hoch, J. A. & Silhavy, T. J. (Am. Soc. Microbiol., Washington, DC), pp. 319-332.
24. Uhl, M. A. & Miller, J. F. (1995) in Two-Component Signal Transduction, eds. Hoch, J. A. & Silhavy, T. J. (Am. Soc. Microbiol., Washington, DC), pp. 333-349.
25. Hecht, G. B., Lane, T., Ohta, N., Sommer, J. & Newton, A. (1995) EMBO J. 14, 3915-3924.
26. Quon, K. C., Marczynski, G. T. & Shapiro, L. (1996) Cell 84, 83-93.
27. Roychoudhury, S., Zielinski, N. A., Ninfa, A. J., Allen, N. E., Jungheim, L. N., Nicas, T. I. & Chakrabarty, A. M. (1993) Proc. Natl. Acad. Sci. USA 90, 965-969.
28. Perego, M., Cole, S. P., Burbulys, D., Trach, K. A. & Hoch, J. A. (1989) J. Bacteriol. 171, 6187-6196.
29. Jin, T. & Inouye, M. (1993) J. Mol. Biol. 232, 484-492.
30. Utsumi, R., Brissette, R. E., Rampersaud, A., Forst, S. A., Oosawa, K. & Inouye, M. (1989) Science 245, 1246-1249.
31. Miller, J. H. (1972) in Experiments in Molecular Genetics, (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 352-355.
32. Burbulys, D., Trach, K. A. & Hoch, J. A. (1991) Cell 64, 545-552.
33. Chopra, I. & Hacker, K. (1992) J. Antimicrob. Chemother. 29, 19-25.
34. Desnottes, J. (1996) Trends Biotechnol. 14, 134-140.
35. Kunst, F., Ogasawara, N., Moszer, I., Albertini, A. M., Alloni, G., Azevedo, V., Bertero, M. G., Bessieres, P., Bolotin, A., Borchen, S., et al. (1997) Nature (London) 390, 249-256.
36. Blattner, F. R., Plunkett, G., III, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., et al. (1997) Science 277, 1453-1474.
37. Fleischmann, R. D., Adams, M. D., White, O., Clayton, R. A., Kirkness, E. F., Kerlavage, A. R., Bult, C. J., Tomb, J. F., Dougherty, B. A., Merrick, J. M., et al. (1995) Science 269, 496-512.
38. Fraser, C. M., Casjens, S., Huang, W. M., Sutton, G. G., Clayton, R., Lathigra, R., White, O., Ketchum, K. A., Dodson, R., Hickey, E. K., et al. (1997) Nature (London) 390, 580-586.
39. Fraser, C. M., Gocayne, J. D., White, O., Adams, M. D., Clayton, R. A., Fleischmann, R. D., Bult, C. J., Kerlavage, A. R., Sutton, G., Kelley, J. M., et al. (1995) Science 270, 397-403.
40. Min, K.-T., Hilditch, C. M., Diederich, B., Errington, J. & Yudkin, M. D. (1993) Cell 74, 735-742.
41. Harris, R. A., Hawes, J. W., Popov, K. M., Zhao, Y., Shimomura, Y., Sato, J., Jaskiewicz, J. & Hurley, T. D. (1997) Adv. Enzyme Regul. 37, 271-293.
42. Harris, R. A., Popov, K. M., Zhao, Y., Kedishvili, N. Y., Shimomura, Y. & Crabb, D. W. (1995) Adv. Enzyme Regul. 35, 147-162.
43. Arthur, M., Depardieu, F., Holman, T., Wu, Z., Wright, G., Walsh, C. T. & Courvalin, P. (1995) in Two-Component Signal Transduction, eds. Hoch, J. A. & Silhavy, T. J. (Am. Soc. Microbiol., Washington, DC), pp. 387-391.
44. Salyers, A. A., Shoemaker, N. B. & Stevens, A. M. (1995) in Two-Component Signal Transduction, eds. Hoch, J. A. & Silhavy, T. J. (Am. Soc. Microbiol., Washington, DC), pp. 393-400.