Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum

Journal of Bacteriology

Volumn 180, Issue 18, 1998, Pages 4856-4864

  Pagan Ramos E ^a   Song, J ^a   McFalone, M ^a   Mudd, M H ^a   Deretic, V ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; OXIDOREDUCTASE;

ANIMAL CELL; ARTICLE; HOST RESISTANCE; MOLECULAR CLONING; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM MARINUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL;

ACTINOBACTERIA (CLASS); ANIMALIA; CORYNEBACTERINEAE; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM MARINUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0031660550     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.180.18.4856-4864.1998     Document Type: Article

References (54)

1. S in stationary phase. Mol. Microbiol. 13:265-272.
2. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1989. Current protocols in molecular biology. John Wiley & Sons, New York, N.Y.
3. Barker, L. P., K. M. George, S. Falkow, and P. L. C. Small. 1997. Differential trafficking of live and dead Mycobacterium marinum organisms in macrophages. Infect. Immun. 65:1497-1504.
4. Chae, H. Z., K. Robinson, L. B. Poole, G. Church, G. Storz, and S. G. Rhee. 1994. Cloning and sequencing of thiol-specitic antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Proc. Natl. Acad. Sci. USA 91:7017-7021.
5. Chan, J., and H. E. Kaufmann. 1994. Immune mechanisms of protection, p. 389-415. In B. R. Bloom (ed.), Tuberculosis: pathogenesis, protection, and control. ASM Press, Washington, D.C.
6. Christman, M. F., R. W. Morgan, F. S. Jacobson, and B. N. Ames. 1985. Positive control of a regulon for defences against oxidative stress and some heat-shock proteins in Salmonella typhimurium. Cell 41:753-762.
7. Clemens, D. L. 1996. Characterization of the Mycobacterium tuberculosis phagosome. Trends Microbiol. 4:133-117.
8. Clemens, D. L., and M. A. Horwitz. 1995. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J. Exp. Med. 181:257-270.
9. Deretic, V., E. Pagan-Ramos, Y. Zhang, S. Dhandayuthapani, and L. E. Via. 1996. The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid. Nat. Biotechnol. 14:1557-1561.
10. Deretic, V., W. Philipp, S. Dhandayuthapani, M. H. Mudd, R. Curcic, T. Garbe, B. Heym, L. E. Via, and S. T. Cole. 1995. Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid. Mol. Microbiol. 17:889-900.
11. Deretic, V., J. Song, and E. Pagan-Ramos. 1997. Loss of oxyR in Mycobacterium tuberculosis. Trends Microbiol. 5:367-372.
12. Deretic, V., L. E. Via, R. Fratti, and D. Deretic. 1997. Mycobacterial phagosome maturation, Rab proteins, and intracellular trafficking. Electrophoresis 18:2542-2547.
13. Dhandayuthapani, S., M. Mudd, and V. Deretic. 1997. Interactions of OxyR with the promoter region of oxyR and ahpC genes from Mycobacterium leprae and Mycobacterium tuberculosis. J. Bacteriol. 179:2401-2409.
14. Dhandayuthapani, S., L. E. Via, C. A. Thomas, P. M. Horowitz, D. Deretic, and V. Deretic. 1995. Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages. Mol. Microbiol. 17:901-912.
15. Dhandayuthapani, S., Y. Zhang, M. H. Mudd, and V. Deretic. 1996. Oxidative stress response and its role in sensitivity to isonicotinic acid hydrazide in Mycobacterium species: characterization and inducibility of ahpC by peroxides in M. smegmatis and lack of expression in M. aurum and M. tuberculosis. J. Bacteriol. 178:3641-3649.
16. Dussurget, O., M. Rodriguez, and I. Smith. 1996. An ideR mutant of Mycobacterium smegmatis has derepressed siderophore production and an altered oxidative-stress response. Mol. Microbiol. 22:535-544.
17. Ehrt, S., M. U. Shiloh, J. Ruan, M. Choi, S. Gunzburg, C. Nathan, and L. W. Riley. 1997. A novel antioxidant gene from Mycobacterium tuberculosis. J. Exp. Med. 186:1885-1896.
18. Eiglmeier, K., H. Fsihi, B. Heym, and S. T. Cole. 1997. On catalase-peroxidase gene, katG, of Mycobacterium leprae and the implications for treatment of leprosy with isoniazid. FEMS Microbiol. Lett. 149:273-278.
19. Falkinham, J. O. 1996. Epidemiology of infection by nontuberculous mycobacteria. Clin. Microbiol. Rev. 9:177-215.
20. Garbe, T. R., N. S. Hibler, and V. Deretic. 1996. Response of Mycobacterium tuberculosis to reactive oxygen and nitrogen intermediates. Mol. Med. 2:134-142.
21. Gordon, A. H., and P. D. Hart. 1994. Stimulation or inhibition of the respiratory burst in cultured macrophages in a mycobacterium model: initial stimulation is followed by inhibition after phagocytosis. Infect. Immun. 62: 4650-4651.
22. Heym, B., Y. Zhang, S. Poulet, D. Young, and S. T. Cole. 1993. Characterization of the katG gene encoding a caralase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis. J. Bacteriol. 175:4255-4259.
23. Jacobs, W. R., G. V. Kalpana, J. D. Cirrilo, L. Pascopella, S. B. Snapper, R. A. Udani, W. Jones, R. G. Barletta, and B. R. Bloom. 1991. Genetic systems for mycobacteria. Methods Enzymol. 204:537-555.
24. Jacobson, F. S., R. W. Morgan, M. F. Christman, and B. N. Ames. 1989. An alkyl hydroperoxide reductase from Salmonella typhimurium involved in the defense of DNA against oxidative damage. J. Biol. Chem. 264:1488-1496.
25. Laochumroonvorapong, P., S. Paul, C. Manca, V. H. Freedman, and G. Kaplan. 1997. Mycobacterial growth and sensitivity to H202 killing in human monocytes in vitro. Infect. Immun. 65:4850-4857.
26. MacMicking, J. D., R. J. North, R. LaCourse, J. S. Mudgett, S. K. Shah, and C. F. Nathan. 1997. Identification of NOS2 as a protective locus against tuberculosis. Proc. Natl. Acad. Sci. USA 94:5243-5248.
27. Musser, J. M. 1995. Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin. Microbiol. Rev. 8:496-514.
28. Nakata, N., M. Matsuoka, Y. Kashiwabara, N. Okada, and C. Sasakawa. 1997. Nucleotide sequence of the Mycobacterium leprae katG region. J. Bacteriol. 179:3053-3057.
29. Ramakrishnan, L., and S. Falkow. 1994. Mycobacterium marinum persists in cultured mammalian cells in a temperature-restricted fashion. Infect. Immun. 62:3222-3229.
30. Ramakrishnan, L., H. T. Tran, N. A. Federspiel, and S. Falkow. 1997. A crtB homolog essential for photocromogenicity in Mycobacterium marinum: isolation, characterization, and gene disruption via homologous recombination. J. Bacteriol. 179:5862-5868.
31. Ramakrishnan, L., R. H. Valdivia, J. H. McKerrow, and S. Falkow. 1997. Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect. Immun. 65:767-773.
32. Rogall, T., J. Wolters, T. Flohr, and E. Bottger. 1990. Towards a phylogeny and definition of species at the molecular level within the genus Mycobacterium. Int. J. Syst. Bacteriol. 40:323-330.
33. Schaffer, S., K. Hantke, and V. Braun. 1985. Nucleotide sequence of the iron regulatory gene fur. Mol. Gen. Genet. 200:110-113.
34. Schell, M. A. 1993. Molecular biology of the LysR family of transcriptional regulators. Annu. Rev. Microbiol. 47:597-626.
35. Schmitt, M. P., M. Predich, L. Doukhan, I. Smith, and R. K. Holmes. 1995. Characterization of an iron-dependent regulatory protein (IdeR) of Mycobacterium tuberculosis as a functional homolog of the diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae. Infect. Immun. 63:4284-4289.
36. Sherman, D. R., K. Mdluli, M. J. Hickey, T. M. Arain, S. L. Morris, C. E. Barry, and C. K. Stover. 1996. Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis. Science 272:1641-1643.
37. Sherman, D. R., P. J. Sabo, M. J. Hickey, T. M. Arain, G. G. Mahairas, Y. Yuan, C. E. Barry, and C. K. Stover. 1995. Disparate responses to oxidative stress in a saprophytic and pathogenic mycobacteria. Proc. Natl. Acad. Sci. USS 92:6625-6629.
38. Snapper, S. B., R. E. Melton, S. Mustafa, T. Kieser, and W. R. Jacobs. 1990. Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol. Microbiol. 4:1911-1919.
39. Song, J., and V. Deretic. Unpublished results.
40. Sreevantsan, S., P. Escalante, X. Pan, D. A. Gilles, S. Siddiqui, C. N. Khalaf, B. N. Kreiswirth, P. Bifani, L. G. Adams, T. Ficht, S. Perumaala, M. D Cave, J. D. A. van Embden, and J. M. Musser. 1996. Identification of a polymorphic nucleotide in oxyR specific from Mycobacterium bovis. J. Clin. Microbiol. 34:2007-2010.
41. Sreevantsan, S., X. Pan, Y. Zhang, V. Deretic, and J. M. Musser. 1997. Analysis of the oxyR-ahpC region in isoniazid-resistant and susceptible Mycobacterium tuberculosis complex organisms recovered from diseased humans and animals in diverse localities. Antimicrob. Agents Chemother. 41: 600-606.
42. Strugill-Koszycki, S., U. E. Schaible, and D. G. Russell. 1996. Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transition state in normal phagosome biogenesis. EMBO J. 15:6960-6968.
43. Strugill-Koszycki, S., P. H. Schlesinger, P. Chakraborty, P. L. Haddix, H. L. Collins, A. K. Fok, R. D. Allen, S. L. Gluck, J. Heuser, and D. G. Russell. 1994. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 263:678-681.
44. Via, L., S. Dhandayuthapani, D. Deretic, and V. Deretic. Green fluorescent protein: a tool for gene expression and cell biology in mycobacteria. Methods Mol. Biol., in press.
45. Via, L. E., D. Deretic, R. J. Ulmer, N. S. Hibler, L. A. Huber, and V. Deretic. 1997. Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7. J. Biol. Chem. 272:13326-13331.
46. Via, L. E., R. A. Fratti, M. McFalone, E. Pagan-Ramos, D. Deretic, and V. Deretic. 1998. Effects of cytokines on mycobacterial phagosome maturation. J. Cell Sci. 111:897-905.
47. Walker, L., and D. B. Lowrie. 1981. Killing of Mycobacterium microti by immunologically activated macrophages. Nature 293:69-70.
48. Wilson, T. M., and D. M. Collins. 1996. ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex. Mol. Microbiol. 19: 1025-1034.
49. Xu, S., A. Cooper, S. Sturgill-Koszycki, T. van Heyningen, D. Chatterjee, I. Orme, P. Allen, and D. G. Russell. 1994. Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages. J. Immunol. 153:2568-2578.
50. Yamaguchi, R., K. Matsuo, A. Yamazaki, M. Takahashi, Y. Fukusawa, M. Wada, and C. Abe. 1992. Cloning and expression of the gene for the Avi-3 antigen of Mycobacterium avium and mapping of its epitopes. Infect. Immun. 60:1210-1216.
51. Young, D. B., and S. T. Cole. 1993. Leprosy, tuberculosis, and the new genetics. J. Bacteriol. 175:1-6.
52. Yuan, Y., R. E. Lee, G. S. Besra, J. T. Belisle, and C. E. Barry III. 1995. Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 92:6630-6634.
53. Zhang, Y., S. Dhandayuthapani, and V. Deretic. 1996. Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid. Proc. Natl. Acad. Sci. USA 93:13212-13216.
54. Zhang, Y., B. Heym, B. Allen, D. Young, and S. T. Cole. 1992. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature 358:591-593.