Inhibition of a Mycobacterium tuberculosis β-Ketoacyl ACP synthase by isoniazid

Science

Volumn 280, Issue 5369, 1998, Pages 1607-1610

  Mdluli, Khisimuzi ^a   Slayden, Richard A ^a   Zhu, YaQi ^a   Ramaswamy, Srinivas ^b   Pan, Xi ^b   Mead, David ^a   Crane, Deborah D ^a   Musser, James M ^b   Barry III, Clifton E ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 OXOACYL ACYL CARRIER PROTEIN SYNTHASE; ACYL CARRIER PROTEIN; HEXACOSANOL; ISONIAZID; MYCOLIC ACID;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATION; CONTROLLED STUDY; DRUG TARGETING; ENZYME INHIBITION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TUBERCULOSIS;

3-OXOACYL-(ACYL-CARRIER-PROTEIN) SYNTHASE; ACYL CARRIER PROTEIN; AMINO ACID SEQUENCE; ANTITUBERCULAR AGENTS; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; FATTY ACIDS; GENES, BACTERIAL; HUMANS; ISONIAZID; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTATION; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; TUBERCULOSIS; UP-REGULATION;

EID: 0032486197     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5369.1607     Document Type: Article

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34. We thank H. Caldwell for proofreading the manuscript and the NIH-AIDS Research and Reference Reagent Program of NIAID for providing radioactive INH. Supported by USPHS grant AI37004 to J.M.M.