Mapping of Mycobacterium tuberculosis katG promoters and their differential expression in infected macrophages

Journal of Bacteriology

Volumn 183, Issue 13, 2001, Pages 4033-4039

  Master, S ^a   Zahrt, T C ^a   Song, J ^a   Deretic, V ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CATALASE; ISONIAZID; KATG PROTEIN; PEROXIDASE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; ASSAY; BACTERIAL GENETICS; BACTERIAL GROWTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEFENSE MECHANISM; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE FUSION; GENE INDUCTION; GENE MAPPING; GENETIC CODE; GENETIC TRANSCRIPTION; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SURVIVAL; TRANSCRIPTION REGULATION; TUBERCULOSIS;

BACTERIAL PROTEINS; BENZENE DERIVATIVES; GENE EXPRESSION REGULATION, BACTERIAL; HYDROGEN PEROXIDE; MACROPHAGES; MYCOBACTERIUM TUBERCULOSIS; OXIDATIVE STRESS; PEROXIDASES; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; RNA, BACTERIAL; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0034976601     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.183.13.4033-4039.2001     Document Type: Article

References (50)

1. Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes
2. Lipoarabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages
3. Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates
4. Catalase-peroxidase (Mycobacterium tuberculosis KatG) catalysis and isoniazid activation
5. Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited
6. phox-/- mice
7. Pathogenesis of pulmonary tuberculosis: An interplay of tissue-damaging and macrophage-activating immune responses - Dual mechanisms that control bacillary multiplication
8. Mycobacterium tuberculosis phagosome
9. The extreme sensitivity of Mycobacterium tuberculosis to the front-line antituberculosis drug isoniazid
10. Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: Implications for sensitivity to isoniazid
11. Loss of oxyR in Mycobacterium tuberculosis
12. Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages
13. Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: Characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis
14. Oxidative stress responses in Escherichia coli and Salmonella typhimurium
15. Influence of Mycobacterium tuberculosis catalase gene (KatG) expression on nitric oxide production and the intracellular growth of transfected Mycobacterium smegmatis strains within murine macrophages
16. Regulators of membrane trafficking and Mycobacterium tuberculosis phagosome maturation block
17. Homeostatic regulation of intracellular hydrogen peroxide concentration in aerobically growing Escherichia coli
18. Regulation of the furA and catC operon, encoding a ferric uptake regulator homologue and catalase-peroxidase, respectively, in Streptomyces coelicolor A3(2)
19. Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis
20. Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis
21. Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis
22. The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis
23. Genetic systems for mycobacteria
24. Expression of katG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs
25. Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro
26. Some observations on the pathogenicity of isoniazid resistant variants of the tubercle bacilli
27. The katE gene, which encodes the catalase HPII of Mycobacterium avium
28. Virulence in the guinea pig, susceptibility to hydrogen peroxide, and catalase activity of isoniazid-sensitive tubercle bacilli from South Indian and British patients
29. The Mycobacterium tuberculosis katG promoter region contains a novel upstream activator
30. Antimicrobial agent resistance in mycobacteria: Molecular genetic insights
31. Increased expression of Fas ligand on Mycobacterium tuberculosis infected macrophages: A potential novel mechanism of immune evasion by Mycobacterium tuberculosis?
32. Oxidative stress response and characterization of the oxyR-ahpC and furA-katG loci in Mycobacterium marinum
33. Sequestration from immune CD4+ T cells of mycobacteria growing in human macrophages
34. Mycobacterium and Leishmania: Stowaways in the endosomal network
35. Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis
36. Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria
37. Down-regulation of CD1 on antigen-presenting cells by infection with Mycobacterium tuberculosis
38. Green fluorescent protein. A tool for gene expression and cell biology in mycobacteria
39. Drug tolerance in Mycobacterium tuberculosis
40. Predicting the outcome of therapy for pulmonary tuberculosis
41. Mycobacterium tuberculosis KatG is a peroxynitritase
42. Redox potential measurements of the Mycobacterium tuberculosis heme protein KatG and the isoniazid-resistant enzyme KatG(S315T): Insights into isoniazid activation
43. Antisense RNA to ahpC, an oxidative stress defence gene involved in isoniazid resistance, indicates that AhpC of Mycobacterium bovis has virulence properties
44. Toxicity of nitrogen oxides and related oxidants on mycobacteria: M. tuberculosis is resistant to peroxynitrite anion
45. Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis
46. An essential two-component signal transduction system in Mycobacterium tuberculosis
47. Mycobacterial FurA is a negative regulator of catalase-peroxidase gene katG
48. Molecular basis for the exquisite sensitivity of Mycobacterium tuberculosis to isoniazid
49. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
50. The mycelium-associated Streptomyces reticuli catalase-peroxidase, its gene and regulation by FurS