Lipid rafts and little caves: Compartmentalized signalling in membrane microdomains

European Journal of Biochemistry

Volumn 269, Issue 3, 2002, Pages 737-752

  Zajchowski, Laura D ^a   Robbins, Stephen M ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Caveolae; Caveolin; Cholesterol; Glycosphingolipids; Glycosylphosphatidylinositol anchor; Lipid rafts; Membrane microdomains; Signal transduction

Indexed keywords

GROWTH FACTOR RECEPTOR; LIPID;

CELL MEMBRANE; HUMAN; LIPID COMPOSITION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL COMPARTMENTATION; CHOLESTEROL; DISEASE; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; LIPID METABOLISM; MEMBRANE MICRODOMAINS; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, GROWTH FACTOR; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 0036178403     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02715.x     Document Type: Review

References (192)

1. The fine structure of the gall bladder epithelium of the mouse
2. Fine structure of blood capillaries
3. The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles
4. Caveolin, a protein component of caveolae membrane coats
5. Caveolin isoforms differ in their N-terminal protein sequence and subcellular distribution. Identification and epitope mapping of an isoform-specific monoclonal antibody probe
6. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle
7. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family
8. Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo
9. Caveolins, liquid-ordered domains, and signal transduction
10. A detergent-free method for purifying caveolae membrane from tissue culture cells
11. Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells
12. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins
13. Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe
14. Tyrosine kinase receptors concentrated in caveolae-like domains from neuronal plasma membrane
15. Detergent-resistant membrane microdomains from Caco-2 cells do not contain caveolin
16. On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes: Physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes
17. Quantitative analysis of phospholipids in functionally important membrane domains from RBL-2H3 mast cells using tandem high-resolution mass spectrometry
18. Functional rafts in cell membranes
19. Lipid rafts and signal transduction
20. Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment
21. Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking
22. Structure of detergent-resistant membrane domains: Does phase separation occur in biological membranes?
23. GPI-anchored proteins, glycosphingolipids, and sphingomyelin are sequestered to caveolae only after cross-linking
24. Association of GAP-43 with detergent-resistant membranes requires two palmitoylated cysteine residues
25. Cholesterol and sphingolipid enhance the Triton X-100 insolubility of glycosylphosphatidylinositol-anchored proteins by promoting the formation of detergent-insoluble ordered membrane domains
26. Glycosphingolipids are not essential for formation of detergent-resistant membrane rafts in melanoma cells
27. Caveolar structure and protein sorting are maintained in NIH 3T3 cells independent of glycosphingolipid depletion
28. Microdomains of GPI-anchored proteins in living cells revealed by crosslinking
29. Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells
30. Lipid domain structure of the plasma membrane revealed by patching of membrane components
31. GPI-anchored proteins are organized in submicron domains at the cell surface
32. Properties of lipid microdomains in a muscle cell membrane visualized by single molecule microscopy
33. Cellular aspects of transcapillary exchange
34. Potocytosis: Sequestration and transport of small molecules by caveolae
35. Regulated internalization of caveolae
36. Landing on lipid rafts
37. Involvement of cellular caveolae in bacterial entry into mast cells
38. Apolipoprotein-mediated removal of cellular cholesterol and phospholipids
39. A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane
40. Calcium signal transduction from caveolae
41. Purification and characterization of smooth muscle cell caveolae
42. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: Implications for human disease
43. Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains
44. Plasmalemmal caveolae and GPI-anchored membrane proteins
45. Caveolins, a family of scaffolding proteins for organizing 'pre-assembled signaling complexes' at the plasma membrane
46. Differential targeting of shaker-like potassium channels to lipid rafts
47. 2 receptor in caveolae
48. Epidermal growth factor receptor activation is localized within low buoyant density, non-caveolar membrane domains
49. Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae
50. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
51. Antibody cross-linking of the glycosylphosphatidyl-linked protein CD59 on hematopoietic cells induces signaling pathways resembling activation by complement
52. Insulin second messengers
53. Signaling within a caveolae-like membrane microdomain in human neuroblastoma cells in response to fibroblast growth factor
54. The caveolae membrane system
55. Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae
56. Insulin stimulates the tyrosine phosphorylation of caveolin
57. Localization of the insulin receptor in caveolae of adipocyte plasma membrane
58. Regulated migration of epidermal growth factor receptor from caveolae
59. Spatial organization of EGF receptor transmodulation by PDGF
60. Basic fibroblast growth factor (FGF-2) is addressed to caveolae after binding to the plasma membrane of BHK cells
61. Heparan sulfate proteoglycans as transducers of FGF-2 signalling
62. Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin-1
63. Insulin-stimulated glucose uptake involves the transition of glucose transporters to a caveolae-rich fraction within the plasma membrane: Implications for type II diabetes
64. Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins
65. The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation
66. Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/p56lyn
67. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the fyn tyrosine kinase to regulate cellular adhesion
68. Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae
69. Nerve growth factor stimulates the hydrolysis of glycosyl-phosphatidylinositol in PC-12 cells: A mechanism of protein kinase C regulation
70. Insulin stimulates the release of glycosyl phosphatidylinositol-anchored membrane dipeptidase from 3T3-L1 adiopocytes through the action of a phospholipase C
71. GDNF - A stranger in the TGF-β superfamily?
72. GFRα-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation and neuronal survival
73. Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-ret to lipid rafts
74. GDNF triggers a novel Ret-independent Src-kinase family-coupled signaling via a GPI-linked GDNF receptor α1
75. Ret-dependent and - independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells
76. The Eph family in retinal axon guidance
77. Vasculogenesis, angiogenesis, and growth factors: Ephrins enter the fray at the border
78. Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner
79. Urokinase receptor and integrin partnership: Coordination of signaling for cell adhesion, migration and growth
80. A requirement for caveolin-1 and associated kinase fyn in integrin signaling and anchorage-dependent cell growth
81. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling
82. De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin
83. Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G proteins, and CD55) selectively localize in Triton-insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes
84. Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae
85. Annexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activation
86. Interactions between FceRI and lipid raft components are regulated by the actin cytoskeleton
87. The role of lipid rafts in T cell antigen receptor (TCR) signalling
88. Role for lipid rafts in regulating interleukin-2 receptor signaling
89. The immunological synapse: A molecular machine controlling T cell activation
90. Three-dimensional segregation of supramolecular activation clusters in T cells
91. Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation
92. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor
93. T lymphocyte costimulation mediated by reorganization of membrane microdomains
94. The amplification of TCR signaling by dynamic membrane microdomains
95. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
96. Membrane compartmentation is required for effecient T cell activation
97. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
98. T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant microdomains
99. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
100. Dual fatty acylation of p59 (Fyn) is required for association with the T cell receptor zeta chain through phosphotyrosine-Src homology domain-2 interactions
101. Membrane lipid microdomains and the role of PKCθ in T cell activation
102. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: A role for lipid rafts in T cell activation
103. Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids
104. S-Acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes
105. Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation
106. Selective modulation of protein kinase C-theta during T-cell activation
107. The actin cytoskeleton and lymphocyte activation
108. A novel functional interaction between Vav and PKCθ is required for TCR-induced T cell activation
109. The immunological synapse
110. Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition
111. Transmembrane phosphoprotein Cbp positively regulates the activity of the carboxyl-terminal Src kinase, Csk
112. Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the tyrosine kinase Csk and is involved in regulation of T cell activation
113. Release from tonic inhibition of T cell activation through transient displacement of c-terminal Src kinase (Csk) from lipid rafts
114. A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing
115. Observing FcεRI signaling from the inside of the mast cell membrane
116. High resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT
117. Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcεRI and their association with detergent-resistant membranes
118. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibition in a rat mast cell line
119. Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains
120. Structural aspects of the association of FcεRI with detergent-resistant membranes
121. Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment
122. Identification of a cytoplasmic region of CD20 required for its redistribution to a detergent-insoluble membrane compartment
123. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting
124. Transient translocation of the B Cell Receptor and Src Homology 2 domain-containing inositol phosphatase to lipid rafts: Evidence toward a role in calcium regulation
125. Cutting edge: B cell antigen receptor signaling occurs outside lipid rafts in immature B cells
126. Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR
127. The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor
128. Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts
129. Enhanced myogenesis in NCAM-transfected mouse myoblasts
130. Evidence that ganglioside enriched domains are distinct from caveolae in MDCK II and human fibroblast cells in culture
131. Retention of prominin in microvilli reveals distinct cholesterol-based lipid microdomains in the apical plasma membrane
132. Expression of caveolin-1 and polarized formation of invaginated caveolae in Caco-2 and MDCK II cells
133. Caveolin-1 and -2 in the exocytic pathway of MDCK cells
134. Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains
135. Immunoisolation of caveolae with high affinity antibody binding to the oligomeric caveolin cage
136. Phosphatidylinositol 4-phosphate synthesis in immunoisolated caveolae-like vesicles and low buoyant density non-caveolar membranes
137. Separation of 'glycosphingolipid signaling domain' from caveolin-containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signalling
138. Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization
139. Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
140. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
141. Ras oncogenes in human cancer: A review
142. Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase
143. Cholesterol and caveolae: Structural and functional relationships
144. Differential effects of filipin and methyl-β-cyclodextrin on B cell receptor signaling
145. 2+ flux
146. Extraction of cholesterol with methyl-β-cyclodextrin perturbs formation of clathrin-coated vesicles
147. A comparison of the tolerability and efficacy of lovastatin 20 mg and fluvastatin 20 mg in the treatment of primary hypercholesterolemia
148. Exogenous administration of gangliosides displaces GPI-anchored proteins from lipid microdomains in living cells
149. Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains
150. Regulation of caveolin and caveolae by cholesterol in MDCK cells
151. Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy
152. Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein
153. COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform
154. Control of EGF receptor signalling by clathrin-mediated endocytosis
155. Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in RSV-transformed fibro-blasts
156. Reduction of caveolin and caveolae in oncogenically transformed cells
157. Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth
158. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/p44 MAP kinase cascade
159. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells
160. Reduction of caveolin-1 gene expression in lung carcinoma cell lines
161. Elevated expression of caveolin is associated with prostate and breast cancer
162. Analysis of the caveolin-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines
163. Expression of caveolin-1 in human T cell leukemia cell lines
164. Changes in membrane microdomains and caveolae constituents in multidrug-resistant cancer cells
165. Loss of functional caveolae during senescence of human fibroblasts
166. Signal transduction through glyco (sphingo) lipids. Introduction and recent studies on glyco (sphingo) lipid-enriched microdomains
167. Cancer-associated glycosphingolipid antigens: Their structure, organization, function
168. Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria
169. Each caveola contains multiple glycosyl-phosphatidylinositol-anchored membrane proteins
170. Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK)
171. Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transduction
172. The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae
173. Immunoisolation and partial characterization of endothelial plasmalemmal vesicles (caveolae)
174. Requirement of caveolae microdomains in extracellular signal-regulated kinase and focal adhesion kinase activation induced by endothelin-1 in primary astrocytes
175. Compartmentation of cyclic adenosine 3′,5′-monophosphate signaling in caveolae
176. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases
177. Compartmentalized production of ceramide at the cell surface
178. Thy-1 mediated activation of rat mast cells: The role of Thy-1 membrane microdomains
179. The glycophospha-tidylinositol-anchored Thy-1 molecule interacts with the p60 fyn protein tyrosine kinase in T cells
180. Functional expression of the endogenous Thy-1 gene and the transfected murine Thy-1.2 gene in rat basophilic leukemia cells
181. Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens
182. Mouse CD24 as a signalling molecule for integrin-mediated cell binding: Functional and physical association with src-kinases
183. Tissue expression, structure and function of the murine Ly-6 family of molecules
184. Involvement of gangliosides in glycosylphosphatidylinositol-anchored neuronal cell adhesion molecule TAG-1 signalin in lipid rafts
185. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration
186. Cellular isoform of the scrapie agent protein participates in lymphocyte activation
187. Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses
188. Analysis of the domain requirement in Gas1 growth suppressing activity
189. Human BST-1 expressed on myeloid cells functions as a receptor molecule
190. Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses
191. T cell signalling through CD73
192. A possible role for mono (ADP-ribosyl) transferase in the signalling pathway mediating neutrophil chemotaxis