Apolipoprotein-mediated removal of cellular cholesterol and phospholipids

Journal of Lipid Research

Volumn 37, Issue 12, 1996, Pages 2473-2491

  Oram, John F ^a,c   Yokoyama, Shinji ^b,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

apolipoproteins; cardiovascular disease; cellular apolipoprotein binding; cellular lipid transport; high density lipoproteins; lipoprotein metabolism; Tangier disease

Indexed keywords

APOLIPOPROTEIN; BINDING PROTEIN; CHOLESTEROL; PHOSPHOLIPID;

ANIMAL CELL; ARTERY WALL; ATHEROGENESIS; CARDIOVASCULAR DISEASE; FIBROBLAST; GENE TARGETING; LIPID COMPOSITION; LIPID TRANSPORT; LIPOPROTEIN METABOLISM; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; REVIEW; TANGIER DISEASE;

ANIMALS; APOLIPOPROTEINS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CHOLESTEROL; HUMANS; PHOSPHOLIPIDS;

EID: 0030480126     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (164)

1. Gordon, D. J., J. Knoke, J. L. Probstfield, R. Superko, and H. A. Tyroler. 1986. High-density lipoprotein cholesterol and coronary artery disease in hypercholesterolemic men: the Lipid Research Clinics Coronary Primary Prevention Trial. Circulation. 73: 1217-1225.
2. Stampfer, M. J., F. M. Sacks, S. Salvini, W. C. Willett, and C. H. Hennekens. 1991. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N. Engl. J. Med. 325: 373-381.
3. Glomset, J. A. 1968. The plasma lecithin:cholesterol acyltransferase reaction. J. Lipid Res. 9: 155-167.
4. Miller, G. J., and N. E. Miller. 1974. Plasma high density lipoprotein concentration and development of ischaemic heart disease. Lancet. 1: 16-20.
5. Assmann, G., A. von Eckardstein, and H. Funke. 1993. High density lipoproteins, reverse transport of cholesterol, and coronary artery disease. Insights from mutations. Circulation. 87: 11128-11134.
6. Li, H., R. L. Reddick, and N. Maeda. 1993. Lack of apoA-I is not associated with increased susceptibility to atherosclerosis in mice. Arterioscler. Thromb. 13: 1814-1821.
7. Hirano, K., S. Yamashita, Y. Kuga, N. Sakai, S. Nozaki, S. Kihara, T. Arai, K. Yanagi, S. Takami, M. Menju, M. Ishigami, Y. Yoshida, K. Kameda-Takemura, K. Hayashi, and Y. Matsuzawa. 1995. Atherosclerotic disease in marked hyperalphalipoproteinemia. Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase. Arterioscler. Thromb. Vasc. Biol. 15: 1849-1856.
8. Warden, C. H., C. C. Hedrick, J. H. Qiao, L. W. Castellani, and A. J. Lusis. 1993. Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. Science. 261: 469-472.
9. Johnson, W. J., F. H. Mahlberg, G. H. Rothblat, and M. C. Phillips. 1991. Cholesterol transport between cells and high-density lipoproteins. Biochim. Biophys. Acta. 1085: 273-298.
10. Rothblat, G. H., F. H. Mahlberg, W. J. Johnson, and M. C. Phillips. 1992. Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux. J. Lipid Res. 33: 1091-1098.
11. Oram, J. F., E. A. Brinton, and E. L. Bierman. 1983. Regulation of HDL receptor activity in cultured human skin fibroblasts and human arterial smooth muscle cells. J. Clin. Invest. 72: 1611-1621.
12. Schmitz, G., R. Niemann, B. Brennhausen, R. M. Krauss, and G. Assmann. 1985. Regulation of high density lipoprotein receptors in cultured macrophages: role of acyl CoA:cholesterol acyltransferase. EMBO J. 4: 2773-2779.
13. Oram, J. F., A. J. Mendez, J. P. Slotte, and T. F. Johnson. 1991. High density lipoprotein apolipoproteins mediate removal of sterol from intracellular pools but not from plasma membranes of cholesterol-loaded fibroblasts. Arterioscler. Thromb. 11: 403-414.
14. Hara, H., and S. Yokoyama. 1991. Interaction of free apolipoproteins with macrophages: formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol. J. Biol. Chem. 266: 3080-3086.
15. Komaba, A., Q. Li, H. Hara, and S. Yokoyama. 1992. Resistance of smooth muscle cells to assembly of high density lipoproteins with extracellular free apolipoproteins and to reduction of intracellularly accumulated cholesterol. J. Biol. Chem. 267: 17560-17566.
16. Li, Q., A. Komaba, and S. Yokoyama. 1993. Cholesterol is poorly available for free apolipoprotein-mediated cellular lipid efflux from smooth muscle cells. Biochemistry. 32: 4597-4603.
17. Mendez, A. J., G. M. Anantharamaiah, J. P. Segrest, and J. F. Oram. 1994. Synthetic amphipathic helical peptides that mimic apolipoprotein A-I in clearing cellular cholesterol. J. Clin. Invest. 94: 1698-1705.
18. Johnson, W. J., M. J. Bamberger, R. A. Latta, P. E. Rapp, M. C. Phillips, and G. H. Rothblat. 1986. The bidirectional flux of cholesterol between cells and lipoproteins: effects of phospholipid depletion of high density lipoprotein. J. Biol. Chem. 261: 5766-5776.
19. Johnson, W. J., F. H. Mahlberg, G. K. Chacko, M. C. Phillips, and G. H. Rothblat. 1988. The influence of cellular and lipoprotein cholesterol contents on the flux of cholesterol between fibroblasts and high density lipoproteins. J. Biol. Chem. 263: 14099-14106.
20. DeLamatre, J., G. Wolfbauer, M. C. Phillips, and G. H. Rothblat. 1986. Role of apolipoproteins in cellular cholesterol efflux. Biochem. Biophys. Acta. 875: 419-428.
21. Mahlberg, F. H., J. M. Glick, S. Lund-Katz, and G. H. Rothblat. 1991. Influence of apolipoproteins AI, AII, and Cs on the metabolism of membrane and lysosomal cholesterol in macrophages. J. Biol. Chem. 266: 19930-19937.
22. Mahlberg, F. H., and G. H. Rothblat. 1992. Cellular cholesterol efflux. Role of cell membrane kinetic pools and interaction with apolipoproteins AI, AII, and Cs. J. Biol. Chem. 267: 4541-4550.
23. Davidson, W. S., S. Lund-Katz, W. J. Johnson, G. M. Anantharamaiah, M. N. Palgunachari, J. P. Segrest, G. H. Rothblat, and M. C. Phillips. 1994. The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein. J. Biol. Chem. 269: 22975-22982.
24. Davidson, W. S., K. L. Gillotte, S. Lund-Katz, W. J. Johnson, G. H. Rothblat, and M. C. Phillips. 1995. The effect of high density lipoprotein phospholipid acyl chain composition on the efflux of cellular free cholesterol. J. Biol. Chem. 270: 5882-5890.
25. Davidson, W. S., W. V. Rodrigueza, S. Lund-Katz, W. J. Johnson, G. H. Rothblat, and M. C. Phillips. 1995. Effects of acceptor particle size on the efflux of cellular free cholesterol. J. Biol. Chem. 270: 17106-17113.
26. Czarnecka, H., and S. Yokoyama. 1995. Lecithin:cholesterol acyltransferase reaction on cellular lipid released by free apolipoprotein-mediated efflux. Biochemistry. 34: 4385-4392.
27. Czarnecka, H., and S. Yokoyama. 1996. Regulation of cellular cholesterol efflux by lecithin:cholesterol acyltransferase reaction through nonspecific lipid excange. J. Biol. Chem. 271: 2023-2028.
28. Hara, H., and S. Yokoyama. 1992. Role of apolipoproteins in cholesterol efflux from macrophages to lipid microemulsion: proposal of a putative model for the pre-β high density lipoprotein pathway. Biochemistry. 31: 2040-2046.
29. Francis, G. A., R. H. Knopp, and J. F. Oram. 1995. Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier disease. J. Clin. Invest. 96: 78-87.
30. Oram, J. F., G. J. Johnson, and T. A. Brown. 1987. Interaction of high density lipoprotein with its receptor on cultured fibroblasts and macrophages: evidence for reversible binding at the cell surface without internalization. J. Biol. Chem. 262: 2405-2410.
31. Forte, T. M., R. Goth-Goldstein, R. W. Nordhausen, and M. R. McCall. 1993. Apolipoprotein A-I cell membrane interaction: extracellular assembly of heterogeneous nascent HDL particles. J. Lipid Res. 34: 317-324.
32. Forte, T. M., J. K. Bielicki, L. Knoff, and M. R. McCall. 1996. Structural relationships between nascent apoA-I-containing particles that are extracellularly assembled in cell culture. J. Lipid Res. 37: 1076-1085.
33. Bielicki, J. K., W. J. Johnson, J. M. Glick, and G. H. Rothblat. 1991. Efflux of phospholipid from fibroblasts with normal and elevated levels of cholesterol. Biochim. Biophys. Acta. 1085: 7-14.
34. Bielicki, J. K., W. J. Johnson, R. B. Weinberg, J. M. Glick, and G. H. Rothblat. 1992. Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol. J. Lipid Res. 33: 1699-1709.
35. Yancey, P. G., J. K. Bielicki, W. J. Johnson, S. Lund-Katz, M. N. Palgunachari, G. M. Anantharamaiah, J. P. Segrest, M. C. Phillips, and G. H. Rothblat. 1995. Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides. Biochemistry. 34: 7955-7965.
36. Oram, J. F. 1983. The effects of HDL subfractions on cholesterol homeostasis in human fibroblasts and arterial smooth muscle cells. Arteriosclerosis. 3: 420-432.
37. Mendez, A. J., J. F. Oram, and E. L. Bierman. 1991. Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol. J. Biol. Chem. 266: 10104-10111.
38. Oram, J. F., J. J. Albers, M. C. Cheung, and E. L. Bierman. 1981. The effects of subfraction of high density lipoprotein on cholesterol efflux from fibroblasts. Regulation of low density lipoprotein receptor activity. J. Biol. Chem. 256: 8348-8356.
39. Savion, N., and S. Kotev-Emeth. 1993. Role of apolipoproteins A-I, A-II and C-I in cholesterol efflux from endothelial and smooth muscle cells. Eur. Heart J. 14: 930-935.
40. Hara, H., H. Hara, A. Komaba, and S. Yokoyama. 1992. α-Helical requirements for free apolipoproteins to generate HDL and to induce cellular lipid efflux. Lipids. 27: 302-304.
41. Li, Q., and S. Yokoyama. 1995. Independent regulation of cholesterol incorporation into free apolipoprotein-mediated cellular lipid efflux in rat vascular smooth muscle cells. J. Biol. Chem. 270: 26216-26223.
42. Forte, T. M., J. K. Bielicki, R. Goth-Goldstein, J. Selmek, and M. R. McCall. 1995. Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT. J. Lipid Res. 36: 148-157.
43. Segrest, J. P., M. K. Jones, H. DeLoof, C. G. Brouillette, Y. V. Venkatachalapathi, and G. M. Anantharamaiah. 1992. The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function. J. Lipid Res. 33: 141-166.
44. Brinton, E. A., R. Kenagy, J. F. Oram, and E. L. Bierman. 1985. Regulation of high density lipoprotein binding activity of aortic endothelial cells by treatment with acetylated low density lipoprotein. Arteriosclerosis. 5: 329-335.
45. Brinton, E. A., J. F. Oram, C. H. Chen, J. J. Albers, and E. L. Bierman. 1986. Binding of high density lipoprotein cultured fibroblasts after chemical alteration of apoprotein amino acid residues. J. Biol. Chem. 261: 495-503.
46. Leblond, L., and Y. L. Marcel. 1991. The amphipathic alpha-helical repeats of apolipoprotein A-I are responsible for binding of high density lipoproteine to HepG2 cells. J. Biol. Chem. 266: 6058-6067.
47. Tsujita, M., and S. Yokoyama. 1996. Selective inhibition of free apolipoprotein-mediated cellular lipid efflux by probucol. Biochemistry. 40: 13011-13020.
48. 3 structure. J. Lipid Res. 24: 245-252.
49. Kunitake, S. T., G. C. Chen, S.-F. Kung, J. W. Schilling, D. A. Hardman, and J. P. Kane. 1990. Pre-beta high density lipoprotein. Unique disposition of apolipoprotein A-I increases susceptibility to proteolysis. Arteriosclerosis. 10: 25-31.
50. Tajima, S., S. Yokoyama, and A. Yamamoto. 1983. Effect of lipid particle size on association of apolipoproteins with lipid. J. Biol. Chem. 258: 10073-10082.
51. Yokoyama, S., U. Kawai, S. Tajima, and A. Yamamoto. 1985. Behavior of apolipoprotein E in aqueous solutions and at interfaces. J. Biol. Chem. 260: 16375-16382.
52. Mazzone, T., and L. Pustelnikas. 1990. Growth-related modulation of human skin fibroblast cholesterol distribution and metabolism. Biochim. Biophys. Acta 1047: 180-186.
53. Li, Q., H. Czarnecka, and S. Yokoyama. 1995. Involvement of a cellular surface factor(s) in lipid-free apolipoprotein-mediated cellular cholesterol efflux. Biochim. Biophys. Acta. 1259: 227-234.
54. Graham, D. L., and J. F. Oram. 1987. Identification and characterization of a high density lipoprotein-binding protein in cell membrane by ligand blotting. J. Biol. Chem. 262: 7439-7442.
55. Hokland, B. M., A. J. Mendez, and J. F. Oram. 1992. Cellular localization and characterization of proteins that bind high density lipoprotein. J. Lipid Res. 33: 1335-1342.
56. Hidaka, H., and N. H. Fidge. 1992. Affinity purification of the hepatic high-density lipoprotein receptor identifies two acidic glycoproteins and enables further characterization of their binding properties. Biochem. J. 284: 161-167.
57. Bond, H. M., G. Morrone, S. Venuta, and K. E. Howell. 1991. Characterization and purification of proteins which bind high-density lipoprotein. Biochem. J. 279: 633-641.
58. de Crom, R. P., R. van Haperen, P. Visser, R. Willemsen, and A. W. van der Kamp. 1994. Structural relation between HDL-binding proteins in porcine liver. Arterioscler. Thromb. 14: 305-312.
59. McKnight, G. L., J. Reasoner, T. Gilbert, K. O. Sundquist, B. M. Hokland, P. A. McKernan, J. Champagne, C. J. Johnson, M. C. Bailey, R. Holly, P. J. O'Hara, and J. F. Oram. 1992. Cloning and expression of a cellular high density lipoprotein-binding protein that is up-regulated by cholesterol loading of cells. J. Biol. Chem. 267: 12131-12141.
60. Acton, S., A. Rigotti, K. T. Landschulz, S. Xu, H. H. Hobbs, and M. Krieger. 1996. Identification of scavenger receptor SR-B1 as a high density lipoprotein receptor. Science. 271: 518-520.
61. Blackburn, W. D., J. G. Dohlman, Y. V. Venkatachalapathi, D. J. Pillion, W. J. Koopman, J. P. Segrest, and G. M. Anantharamaiah. 1991. Apolipoprolein A-I decreases neutrophil degranulation and superoxide production. J. Lipid Res. 32: 1911-1918.
62. Higgins, C. F., and M. M. Gottesman. 1992. Is the multidrug transporter a flippase? Trends Biochem. Sci. 17: 18-21.
63. Fielding, P. E., and C. J. Fielding. 1995. Plasma membrane caveolae mediate the efflux of cellular free cholesterol. Biochemistry. 34: 14288-14292.
64. Anderson, R. G. W. 1993. Caveolae: where incoming and outgoing messengers meet (review). Proc. Natl. Acad. Sci. USA. 90: 10909-10913.
65. Slotte, J. P., J. F. Oram, and E. L. Bierman. 1987. Binding of high density lipoprotein to cell receptors promotes translocation of cholesterol from intracellular membranes to the cell surface. J. Biol. Chem. 262: 12904-12907.
66. Aviram, M., E. L. Bierman, and J. F. Oram. 1989. High density lipoprotein stimulates sterol translocation between intracellular and plasma membrane pools in human monocyte-derived macrophages. J. Lipid Res. 30: 65-76.
67. Hokland, B. M., J. P. Slotte, E. L. Bierman, and J. F. Oram. 1993. Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells. J. Biol. Chem. 268: 25343-25349.
68. Walter, M., U. Gerdes, U. Seedorf, and G. Assmann. 1994. The high density lipoprotein apolipoprotein A-I-induced mobilization of cellular cholesterol is impaired in fibroblasts from Tangier disease subjects. Biochem. Biophys. Res. Commun. 205: 850-856.
69. Rogler, G., B. Trumbach, B. Klima, K. J. Lachner, and G. Schmitz. 1995. High density lipoprotein-mediated efflux of newly synthesized cholesterol is impaired in fibroblasts from Tangier patients while membrane desorption and efflux of lysosomal cholesterol are normal. Arterioscler. Thromb. Vasc. Biol. 15: 683-690.
70. Sviridov, D., and N. Fidge. 1995. Efflux of intracellular versus plasma membrane cholesterol in HepG2 cells: different availability and regulation by apolipoprotein A-I. J. Lipid Res. 36: 1887-1896.
71. Sviridov, D., L. Pyle, and N. Fidge. 1996. Identification of a sequence of apolipoprotein A-I associated with the efflux of intracellular cholesterol to human serum and apolipoprotein A-I-containing particles. Biochemistry. 35: 189-196.
72. Francis, G. A., A. J. Mendez, E. L. Bierman, and J. W. Heinecke. 1993. Oxidative tyrosylation of high density lipoprotein by peroxidase enhances cholesterol removal from cultured fibroblasts and macrophage foam cells. Proc. Natl. Acad. Sci. USA. 90: 6631-6635.
73. Lange, Y. 1992. Tracking cell cholesterol with cholesterol oxidase. J. Lipid Res. 33: 315-322.
74. Lange, Y., and J. L. Steck. 1985. Cholesterol-rich intracellular membranes: a precursor to the plasma membrane. J. Biol. Chem. 260: 15592-15596.
75. Lange, Y. 1991. Disposition of intracellular cholesterol in human fibroblasts. J. Lipid Res. 32: 329-339.
76. Lange, Y. 1994. Cholesterol movement from plasma membrane to rough endoplasmic reticulum. Inhibition by progesterone. J. Biol. Chem. 269: 3411-3414.
77. Liscum, L., and N. K. Dahl. 1992. Intracellular cholesterol transport. J. Lipid Res. 33: 1239-1254.
78. Liscum, L., and K. W. Underwood. 1995. Intracellular cholesterol transport and compartmentation. J. Biol. Chem. 270: 15443-15446.
79. Mendez, A. J. 1995. Monensin and Brefeldin A inhibit high density lipoprotein-mediated cholesterol efflux from cholesterol-enriched cells. Implications for intracellular cholesterol transport. J. Biol. Chem. 270: 5891-5900.
80. Mendez, A. J., and L. Uint. 1996. Apolipoprotein-mediated cellular cholesterol and phospholipid efflux depend on a functional Golgi apparatus. J. Lipid Res. 37: 2510-2524.
81. Conrad, P. A., E. J., Smart, Y. S. Ying, R. G. Anderson, and G. S. Bloom. 1995. Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps. J. Cell Biol. 131: 1421-1433.
82. Xu, X. X., and I. Tabas. 1991. Lipoproteins activate acylcoenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level. J. Biol. Chem. 266: 17040-17048.
83. Puglielli, L., A. Rigotti, A. V. Greco, M. J. Santos, and F. Nervi. 1995. Sterol carrier protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts. J. Biol. Chem. 270: 18723-18726.
84. Hu, R. M., M. Y. Chuang, B. Prins, M. L. Kashyap, H. J. Frank, A. Pedram, and E. R. Levin. 1994. High density lipoproteins stimulate production and secretion of endothelin-1 from cultured bovine aortic endothelial cells. J. Clin. Invest. 93: 1056-1062.
85. Ong, A. C., T. P. Jowett, J. F. Moorhead, and J. S. Owen. 1994. Human high density lipoproteins stimulate endothelin-1 release by cultured human renal proximal tubular cells. Kidney Int. 46: 1315-1321.
86. Wu, Y. Q., and S. Handwerger. 1992. High density lipoproteins stimulate molecular weight 80 K protein phosphorylation in human trophoblast cells: evidence for a protein kinase-C-dependent pathway in human placental lactogen release. Endocrinology. 131: 2935-2940.
87. Theret, N., C. Delbart, G. Aguie, J. D. Fruchart, G. Vassaux, and G. Ailhaud. 1990. Cholesterol efflux from adipose cells is coupled to diacylglycerol production and protein kinase C activation. Biochem. Biophys. Res. Commun. 173: 1361-1368.
88. Dusserre, E., T. Pulcini, M. C. Bourdillon, and F. Berthezene. 1994. High-density lipoprotein 3 stimulates phosphatidylcholine breakdown and sterol translocation in rat aortic smooth muscle cells by a phospholipase C/protein kinase C-dependent process. Biochem. Med. Metab. Biol. 52: 45-52.
89. 3 and LDL is markedly reduced in cultured fibroblasts from Tangier patients. Arterioscler. Thromb. Vasc. Biol. 15: 1369-1377.
90. Voyno-Yasenetskaya, T. A., L. G. Dobbs, S. K. Erickson, and R. L. Hamilton. 1993. Low density lipoprotein and high density lipoprotein-mediated signal transduction and exocytosis in alveolar type II cells. Proc. Natl. Acad. Soc. USA. 90: 4256-4260.
91. 2+ in cultured fibroblasts. Biochem. J. 279: 29-33.
92. Mollers, C., W. Drobnik, T. Resink, and G. Schmitz. 1995. High-density lipoprotein and low-density lipoprotein-mediated signal transduction in cultured human skin fibroblasts. Cell Signal. 7: 695-707.
93. 3 stimulates multiple signaling pathways in human skin fibroblasts. Arterioscler. Thromb. Vasc. Biol. 15: 1975-1986.
94. Fredrickson, D. S., P. H. Altrocchi, L. V. Avioli, D. S. Goodman, and H. C. Goodman. 1961. Tangier disease: combined clinical staff conference at the National Institute of Health. Ann. Intern. Med. 55: 1016-1031.
95. Fredrickson, D. S. 1964. The inheritance of high density lipoprotein deficiency (Tangier disease). J. Clin. Invest. 43: 228-236.
96. Assmann, G. A., A. von Eckardstein, and H. B. Brewer. 1995. Familial HDL deficiency: Tangier disease. In The Metabolic Basis of Inherited Disease. C. R. Scriver, A. L. Beaudet, W. S. Sly and D. Valle, editors. McGraw-Hill Book Co. New York. 2053-2072.
97. Bojanovski, D., R. E. Gregg, L. A. Zech, M. S. Meng, C. Bishop, R. Ronan, and H. B. Brewer, Jr. 1987. In vivo metabolism of proapolipoprotein A-I in Tangier disease. J. Clin. Invest. 80: 1042-1047.
98. Tangier and the amino acid sequence of the propeptide. Biochim. Biophys. Res. Commun. 113: 934-940.
99. Law, S. W., and H. B. Brewer, Jr. 1985. Tangier disease: the complete amino acid sequence for proapo A-I. J. Biol. Chem. 260: 12810-12814.
100. Remaley, A. T., J. A. Stonik, U. K. Schumacher, J. M. Hoeg, and H. B. Brewer, Jr. 1995. Defective phospholipid efflux from Tangier disease fibroblasts. Circulation. 92: 1-556 Abstract.
101. Fielding, C. J., and P. E. Fielding. 1995. Molecular physiology of reverse cholesterol transport. J. Lipid Res. 36: 211-228.
102. Fielding, P. E., M. Kawano, A. L. Catapano, A. Zoppo, S. Marcovina, and C. J. Fielding. 1994. Unique epitope of apolipoprotein A-I expressed in pre-beta-1 high-density lipoprotein and its role in the catalyzed efflux of cellular cholesterol. Biochemistry. 33: 6981-6985.
103. Reichl, D., C. B. Hathaway, J. M. Sterchi, and N. E. Miller. 1991. Lipoproteins of human peripheral lymph. Apolipoprotein A-I-containing lipoprotein with alpha-2 electrophoretic mobility. Eur. J. Clin. Invest. 21: 631-643.
104. Asztalos, B. F., C. H. Sloop, L. Wong, and P. S. Roheim. 1993. Comparison of apoA-I-containing subpopulations of dog plasma and prenodal peripheral lymph: evidence for alteration of subpopulations in the interstitial space. Biochim. Biophys. Acta. 1169: 301-304.
105. Wong, L., B. Sivok, E. Kurucz, C. H. Sloop, P. S. Roheim, and B. Asztalos. 1995. Lipid composition of HDL subfractions in dog plasma and lymph. Arterioscler. Thromb. Vasc. Biol. 15: 1875-1881.
106. Heideman, C. L., and H. F. Hoff. 1982. Lipoproteins containing apolipoprotein A-I extracted from human aortas. Biochim. Biophys. Acta. 711: 431-444.
107. Smith, E. B., C. Ashall, and J. E. Walker. 1984. High density lipoprotein (HDL) subfractions in interstitial fluid from human aortic intima and atherosclerotic lesions. Biochem. Soc. Trans. 12: 843-844.
108. Miida, T., M. Kawano, C. J. Fielding, and P. E. Fielding. 1992. Regulation of the concentration of pre-beta high-density lipoprotein in normal plasma by cell membranes and lecithin:cholesterol acyltransferase activity. Biochemistry. 31: 11112-11117.
109. Kawano, M., T. Miida, C. J. Fielding, and P. E. Fielding. 1993. Quantitation of pre-β-HDL-dependent and non-specific components of the total efflux of cellular cholesterol and phospholipid. Biochemistry. 32: 5025-5028.
110. Cheung, M. C., A. J. Mendez, A. C. Wolf, and R. H. Knopp. 1993. Characterization of apolipoprotein A-I-and A-II-containing lipoproteins in a new case of high density lipoprotein deficiency resembling Tangier disease and their effects on intracellular cholesterol efflux. J. Clin. Invest. 91: 522-529.
111. von Eckardstein, A., Y. Huang, S. Wu, H. Funke, G. Noseda, and G. Assmann. 1995. Reverse cholesterol transport in plasma of patients with different forms of familial HDL deficiency. Arterioscler. Thromb. Vasc. Biol. 15: 691-703.
112. Hennessy, L. K., S. T. Kunitake, and J. P. Kane. 1993. Apolipoprotein A-I-containing lipoproteins, with or without apolipoprotein A-II, as progenitors of pre-beta high-density lipoprotein particles. Biochemistry. 32: 5759-5765.
113. Kunitake, S. T., G. M. Mendel, and L. K. Hennessy. 1992. Interconversion between apolipoprotein A-I-containing lipoproteins of pre-beta and alpha electrophoretic mobilities. J. Lipid Res. 33: 1807-1816.
114. Asztalos, B. F., and P. S. Roheim. 1995. Presence and formation of 'free apolipoprotein A-I-like' particles in human plasma. Arterioscler. Thromb. Vasc. Biol. 15: 1419-1423.
115. 2. J. Biol. Chem. 269: 11572-11577.
116. Clay, M. A., H. H. Newnham, T. M. Forte, and P. I. Barter. 1992. Cholesteryl ester transfer protein and hepatic lipase activity promote shedding of apoA-I from HDL and subsequent formation of discoidal HDL. Biochim. Biophys. Acta. 1124: 52-58.
117. Liang, H., K., Rye, and P. J. Barter. 1995. Cycling of apolipoprotein A-I between lipid-associated and lipid-free pools. Biochim. Biophys. Acta. 1257: 31-37.
118. Pussinen, P., M. Jauhiainen, J. Metso, J. Tyynelä, C. Enholm. 1995. Pig plasma phospholipid transfer protein facilities HDL interconversion. J. Lipid Res. 36: 975-985.
119. Hamilton, R. L., L. S. Guo, T. E. Felker, Y. S. Chao, and R. J. Havel. 1986. Nascent high density lipoproteins from liver perfusates of orotic acid-fed rats. J. Lipid Res. 27: 967-978.
120. Johnson, F. L., J. Babiak, and L. L. Rudel. 1986. High density lipoprotein accumulation in perfusates of isolated livers of African green monkeys: effects of saturated versus polyunsaturated dietary fat. J. Lipid Res. 27: 537-548.
121. Johnson, F. L., L. L. Swift, and L. L. Rudel. 1987. Nascent lipoproteins from recirculating and nonrecirculating liver perfusions and from the hepatic Golgi apparatus of African green monkeys. J. Lipid Res. 28: 549-564.
122. McCall, M. R., T. M. Forte, and V. G. Shore. 1988. Heterogeneity of nascent high density lipoproteins secreted by the hepatoma-derived cell line, HepG2. J. Lipid Res. 29: 1127-1137.
123. Forte, T. M., M. R. McCall, B. B. Knowles, and V. G. Shore. 1989. Isolation and characterization of lipoproteins produced by human hepatoma-derived cell lines other than HepG2. J. Lipid Res. 30: 817-829.
124. Hughes, T. E., W. V. Sasak, J. M. Ordovas, T. M. Forte, S. Lamon-Fava, and E. J. Schaefer. 1987. A novel cell line (Caco-2) for the study of intestinal lipoprotein synthesis. J. Biol. Chem. 262: 3762-3767.
125. Black, D. D., and P. L. Rohwer-Nutter. 1991. Intestinal apolipoprotein synthesis in the newborn piglet. Pediatric Res. 29: 32-38.
126. Huang, Y., A. Eckardstein, S. Wu, N. Maeda, and G. Assmann. 1994. A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells. Proc. Natl. Acad. Sci. USA. 91: 1834-1838.
127. von Eckardstein, A., Y. Huang, S. Wu, A. S. Sarmadi, S. Schwartz, A. Steinmetz, and G. Assmann. 1995. Lipoproteins containing apolipoprotein A-IV but not apolipoprotein A-I take up and esterify cell-derived cholesterol in plasma. Arterioscler. Thromb. Vasc. Biol. 15: 1755-1763.
128. Basu, S. K., M. S. Brown, Y. K. Ho, R. J. Havel, and J. L. Goldstein. 1981. Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E. Proc. Natl. Acad. Sci. USA. 78: 7545-7549.
129. Tall, A. R. 1993. Plasma cholesteryl ester transfer protein. J. Lipid Res. 34: 1255-1274.
130. Glass, C., R. C. Pittman, M. Given, and D. Steinberg. 1985. Uptake of high-density lipoprotein-associated apoprotein A-I and cholesterol esters by 16 tissues of the rat in vivo and by adrenal cells and hepatocytes in vitro, J. Biol. Chem. 260: 744-750.
131. Horowitz, B. S., J. J. Goldberg, J. Merab, T. M. Vanni, R. Ramakrishnan, and H. N. Ginsberg. 1993. Increased plasma and renal clearance of an exchangeable pool of apolipoprotein A-I in subjects with low levels of high density lipoprotein cholesterol. J. Clin. Invest. 91: 1743-1752.
132. Schwartz, C. G., L. A. Zech, J. M. VandenBroek, and P. S. Cooper. 1993. Cholesterol kinetics in subjects with bile fistula. J. Clin. Invest. 91: 923-938.
133. Dietschy, J. M., S. D. Turley, and D. K. Spady. 1993. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J. Lipid Res. 34: 1637-1659.
134. Brown, M. S., and J. L. Goldstein. 1986. A receptor-mediated pathway for cholesterol homeostasis. Science. 232: 34-47.
135. Brown, M. S., and J. L. Goldstein. 1983. Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis. Annu. Rev. Biochem. 52: 223-261.
136. Fadok, V. A., D. R. Voelker, P. A. Campbell, J. J. Cohen, D. L. Bratton, and P. M. Henson. 1992. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunol. 148: 2207-2216.
137. Williams, K. J., and I. Tabas. 1995. The response-to-retention hypothesis of early atherogenesis. Arterioscler. Thromb. Vasc. Biol. 15: 551-561.
138. Schaefer, E. J. 1984. Clinical, biochemical, and genetic features in familial disorders of high density lipoprotein deficiency. Arteriosclerosis. 4: 303-322.
139. milano apoprotein: identification of the complete kindred and evidence of a dominant genetic transmission. Am. J. Hum. Genet. 37: 1083-1097.
140. milano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I. J. Biol. Chem. 258: 2508-2513.
141. milano, associated with familial hypoalphalipoproteinemia. J. Clin. Invest. 91: 1445-1452.
142. Cheung, M. C., and J. J. Albers. 1984. Characterization of lipoprotein particles isolated by immunoaffinity chromatography: particles containing A-I and A-II and particles containing A-I but no A-II. J. Biol. Chem. 259: 12201-12209.
143. Cheung, M. C., A. G. Wolf, R. H. Knopp, and D. M. Foster. 1992. Protein transfer between A-I-containing lipoprotein subpopulations: evidence of non-transferable A-I in particles with A-II. Biochim. Biophys. Acta. 1165: 68-77.
144. Gordon, D. J., and B. M. Rifkind. 1989. High-density lipoprotein - the clinical implications of recent studies. N. Engl. J. Med. 321: 1311-1316.
145. Cheung, M. C., B. G. Brown, A. C. Wolf, and J. J. Alberts. 1991. Altered particle size distribution of apolipoprotein A-I-containing lipoproteins in subjects with coronary artery disease. J. Lipid Res. 32: 383-394.
146. Fruchart, J-C., C. DeGeteire, B. Delfly, and G. R. Castro. 1994. Apolipoprotein A-I-containing particles and reverse cholesterol transport: evidence in connection between cholesterol efflux and atherosclerosis risk. Atherosclerosis. 110: 35-39.
147. Schultz, J. R., J. G. Verstuyft, E. L. Gong, A. V. Nichols, and E. M. Rubin. 1993. Protein composition determines the anti-atherogenic properties of HDL in transgenic mice. Nature. 365: 762-764.
148. Miyazaki, A., S. Sakuma, W. Morikawa, T. Takiue, F. Miake, T. Terano, M. Sakai, H. Hakamata, Y. Sakamoto, M. Naito, Y. Ruan, K. Takahashi, T. Ohta, and S. Horiuchi. 1995. Intravenous injection of rabbit apolipoprotein A-I inhibits the progression of atherosclerosis in cholesterol-fed rabbits. Arterioscler. Thromb. Vasc. Biol. 15: 1882-1888.
149. Rubin, E. M., R. M. Krauss, E. A. Spangler, J. G. Verstuyft, and S. M. Clift. 1991. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI. Nature. 353: 265-267.
150. Liu, A. C., R. M. Lawn, J. G. Verstuyft, and E. M. Rubin. 1994. Human apolipoprotein A-I prevents atherosclerosis associated with apolipoprotein [a] in transgenic mice. J. Lipid Res. 35: 2263-2267.
151. P'aszty, C., N. Maeda, J. Verstuyft, and E. M. Rubin. 1994. Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J. Clin. Invest. 94: 899-903.
152. Plump, A. S., C. J. Scott, and J. L. Breslow. 1994. Human apoliprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc. Natl. Acad. Sci. USA. 91: 9607-9611.
153. Duverger, N., G. Tremp, J-M. Caillaud, F., Emmanuel, G. Castro, J-C. Fruchart, A. Steinmetz, and P. Denefle. 1996. Protection against atherogenesis in mice mediated by human apolipoprotein A-IV. Science. 273: 966-968.
154. Shimano, H., J. Ohsuga, M. Shimada, Y. Namba, T. Gotoda, K. Harada, M. Katsuki, Y. Yazaki, and N. Yamada. 1995. Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall. J. Clin. Invest. 95: 469-476.
155. Bellosta, S., R. W. Mahley, D. A. Sanan, J. Murata, D. L. Newland, J. M.
156. 3. J. Lipid Res. 35: 1345-1353.
157. 3 in mouse macrophages. J. Lipid Res. 32: 783-792.
158. Kruth, H. S., S. I. Skarlatos, P. M. Gaynor, and W. Gamble. 1994. Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux. J. Biol. Chem. 269: 24511-24518.
159. Duell, P. B., J. F. Oram, and E. L. Bierman. 1990. Nonenzymatic glycosylation of HDL resulting in inhibition of high-affinity binding to cultured human fibroblasts. Diabetes. 39: 1257-1263.
160. Duell, P. B., J. F. Oram, and E. L. Bierman. 1991. Nonenzymatic glycosylation of HDL and impaired HDL-receptor-mediated cholesterol efflux. Diabetes. 40: 377-384.
161. Nagano, Y., H. Araki, and T. Kita. 1991. High density lipoprotein loses its effect to stimulate efflux of cholesterol from foam cells after oxidative modification. Proc. Natl. Acad. Sci. USA. 88: 6457-6461.
162. 2+-mediated oxidation. FEBS Lett. 314: 199-202.
163. Cu̇rtiss, L. K., and J. L. Witztum. 1985. Plasma apolipoprotein A-I, A-II, B, C-I and E are glycosylated in hyperglycemic diabetic subjects. Diabetes. 34: 452-461.
164. Serfaty-Lacroshiere, C., F. Civeira, A. Lanzberg, P. Isaia, J. Berg, E. D. Janus, M. P. Smith, Jr., P. H. Pritchard, J. Frohlich, R. S. Lee, G. F. Barnard, J. M. Ordovas, and E. J. Schaefer. 1994. Homozygous Tangier disease and cardiovascular disease. Atherosclerosis. 107: 85-98.