The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor

Journal of Cell Biology

Volumn 150, Issue 3, 2000, Pages 613-625

  Screaton, R A ^a   DeMarte, L ^a   Draber, P ^a   Stanners, C P ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

CEA; GPI anchors; Ig superfamily; Inhibition of differentiation; NCAM

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; GLYCOPROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; IMMUNOGLOBULIN; NERVE CELL ADHESION MOLECULE; SIGNAL PEPTIDE;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL DIFFERENTIATION; CONTROLLED STUDY; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CARCINOEMBRYONIC ANTIGEN; CELL ADHESION; CELL DIFFERENTIATION; CELL MEMBRANE; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUSCLES; NEURAL CELL ADHESION MOLECULES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

ANIMALIA; MURINAE;

EID: 0034618075     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.150.3.613     Document Type: Article

References (79)

1. Use of tumor markers and radiologic tests in follow-up
2. Human biliary glycoprotein gene: Characterization of a family of novel alternatively spliced RNAs and their expressed proteins
3. Complete sequence and in vitro expression of a tissue-specific phosphatidylinositol-linked N-CAM isoform from skeletal muscle
4. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule
5. Studies on the control of gene expression of the carcinoembryonic antigen family in human tissue
6. The tyrosine kinase connection: How GPI-anchored proteins activate T cells
7. Structure of detergent-resistant membrane domains: Does phase separation occur in biological membranes?
8. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
9. Human muscle neural cell adhesion molecule (N-CAM): Identification of a muscle-specific sequence in the extracellular domain
10. Enhanced myogenesis in NCAM-transfected mouse myoblasts
11. Cross-linking of Thy-1 glycoproteins or high-affinity 1gE receptors induces mast cell activation via different mechanisms
12. A novel monoclonal antibody specific for biliary glycoprotein (CD66a)
13. Human carcinoembryonic antigen, an intercellular adhesion molecule, blocks fusion and differentiation of rat myoblasts
14. Altered secondary myogenesis in transgenic animals expressing the neural cell adhesion molecule under the control of a skeletal muscle alpha-actin promoter
15. Characterization of VIP36, an animal lectin homologous to leguminous lectins
16. Glycosphingolipid-enriched, detergent-insoluble complexes in protein sorting in epithelial cells
17. Microdomains of GPI anchored proteins in living cells revealed by crosslinking
18. GPI-anchored proteins, glycosphingolipids, and sphingomyelin are sequestered to caveolae only after crosslinking
19. Glycosylated phosphatidylinositol molecules as second messengers
20. A human β-actin expression vector system directs high-level accumulation of antisense transcripts
21. Lipid domain structure of the plasma membrane revealed by patching of membrane components
22. Carcino-embryonic antigen is anchored to membranes by covalent attachment to a glycosylphosphatidylinositol moiety: Identification of the ethanolamine linkage site
23. Expression of complementary DNA and genomic clones for carcinoembryonic antigen and nonspecific cross-reacting antigen in Chinese hamster ovary and mouse fibroblast cells and characterization of the membrane-expressed products
24. Correlated expression of mRNAs of carcinoembryonic antigen and nonspecific cross-reacting antigen genes in malignant and nonmalignant tissues of the colon
25. Glycosyl-phosphatidylinositol-anchored membrane proteins can be distinguished from transmembrane polypeptide-anchored proteins by differential solubilization and temperature-induced phase separation in Triton X-114
26. Ectoenzymes of the kidney microvillar membrane. Differential solubilization by detergents can predict a glycosyl-phosphatidylinositol membrane anchor
27. Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches
28. Cell-surface levels of human carcinoembryonic antigen are inversely correlated with colonocyte differentiation in colon carcinogenesis
29. COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform
30. Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers
31. Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: Implication as a tumor suppressor
32. Cell adhesion molecules in myogenesis
33. Inhibition of colonic tumor cell growth by biliary glycoprotein
34. Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin
35. Mutations in the middle of the transmembrane domain reverse the polarity of transport of the influenza virus hemagglutinin in MDCK epithelial cells
36. Emerging functional roles for the glycosyl-phosphatidylinositol membrane protein anchor
37. Regulation of lymphocyte function by glycosylphosphatidylinositol (GPI)-anchored proteins
38. Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment
39. Glycophospholipid membrane anchor attachment. Molecular analysis of the cleavage/attachment site
40. Characterization of glycosylphosphatidylinositol (GPI)-anchored NCAM on mouse skeletal muscle cell line C2C12: The structure of the GPI glycan and release during myogenesis
41. Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells
42. Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas
43. Analysis of the sequence requirements for glycosylphosphatidylinositol anchoring of Saccharomyces cerevisiae Gas1 protein
44. CEA adhesion molecules: Multifunctional proteins with signal-regulatory properties
45. Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: Homophilic and heterophilic adhesion
46. Human carcinoembryonic antigen functions as a general inhibitor of anoikis
47. Lipid association, but not the transmembrane domain, is required for tissue factor activity. Substitution of the transmembrane domain with a phosphatidylinositol anchor
48. Differential effects of over-expressed neural cell adhesion molecule isoforms on myoblast fusion
49. Characterization of cell lines showing growth control isolated from both the wild-type and a leucyl-t-RNA synthetase mutant of Chinese hamster ovary cells
50. Identification of a peptide sequence involved in homophilic binding in the neural cell adhesion molecule NCAM
51. Lipid analysis of the glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase. Palmitoylation of inositol results in resistance to phosphatidylinositol-specific phospholipase C
52. Signal transduction by GPI-anchored membrane proteins
53. A glycophospholipid anchor is required for Qa-2-mediated T cell activation
54. Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction
55. Morphogenesis of the polarized epithelial cell phenotype
56. Biliary glycoprotein, a member of the immunoglobulin supergene family, functions in vitro as a Ca2(+)-dependent intercellular adhesion molecule
57. Radical differences in functions of closely related members of the human carcinoembryonic antigen gene family
58. Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain
59. Glycosylphosphatidylinositol toxin of plasmodium upregulates intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction
60. Carcinoembryonic antigen, a human tumor marker, cooperates with Myc and Bcl-2 in cellular transformation
61. Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1
62. Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins
63. Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae
64. Functional rafts in cell membranes
65. Site-directed mutagenesis within an ectoplasmic ATPase consensus sequence abrogates the cell aggregating properties of the rat liver canalicular bile acid transporter/ecto-ATPase/cell CAM 105 and carcinoembryonic antigen
66. The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes
67. Mouse decay-accelerating factor: Selective and tissue-specific induction by estrogen of the gene encoding the glycosylphosphatidylinositol-anchored form
68. The glycosyl phosphatidylinositol anchor is critical for Ly-6A/E-mediated T cell activation
69. Self recognition in the Ig superfamily: Identification of precise sub-domains in CEA required for intercellular adhesion
70. Evidence for carboxyl-terminal processing and glycolipid-anchoring of human carcinoembryonic antigen
71. Prediction of omega site in nascent precursor of glycosylphosphatidylinositol protein
72. Exogenous glycosyl phosphatidylinositol-anchored CD59 associates with kinases in membrane clusters on U937 cells and becomes Ca(2+)-signaling competent
73. GPI-anchored proteins are organized in submicron domains at the cell surface
74. Structural basis for variations in the sensitivity of human decay accelerating factor to phosphatidylinositol-specific phospholipase C cleavage
75. Variant GPI structure in relation to membrane-associated functions of a murine folate receptor
76. Retention of differentiation potentialities during prolonged cultivation of myogenic cells
77. Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells
78. Specificity of intercellular adhesion mediated by various members of the immunoglobulin supergene family
79. Specificity of anti-carcinoembryonic antigen monoclonal antibodies and their effects on CEA-mediated adhesion