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Volumn 250, Issue 1, 1999, Pages 231-240

Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transduction

Author keywords

Cell migration; UPA; UPAR; 1 integrin

Indexed keywords

FIBRONECTIN; INTEGRIN; UROKINASE; UROKINASE RECEPTOR;

EID: 0033542781     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4510     Document Type: Article
Times cited : (107)

References (45)
  • 1
    • 0027535914 scopus 로고
    • Biology and biochemistry of proteinases in tumor invasion
    • Mignatti P., Rifkin D. B. Biology and biochemistry of proteinases in tumor invasion. Physiol. Rev. 73:1993;161-195.
    • (1993) Physiol. Rev. , vol.73 , pp. 161-195
    • Mignatti, P.1    Rifkin, D.B.2
  • 2
    • 0030788411 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator system in cancer metastasis: A review
    • Andreasen P. A., Kjoller L., Christensen L., Duffy M. J. The urokinase-type plasminogen activator system in cancer metastasis: A review. Int. J. Cancer. 72:1997;1-22.
    • (1997) Int. J. Cancer , vol.72 , pp. 1-22
    • Andreasen, P.A.1    Kjoller, L.2    Christensen, L.3    Duffy, M.J.4
  • 3
    • 0030842795 scopus 로고    scopus 로고
    • Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
    • Chapman H. A. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Curr. Opin. Cell Biol. 9:1997;714-724.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 714-724
    • Chapman, H.A.1
  • 4
    • 0032032910 scopus 로고    scopus 로고
    • The urokinase-type-plasminogen-activator receptor (CD87) is a pleiotropic molecule
    • Dear A. E., Metcalf R. L. The urokinase-type-plasminogen-activator receptor (CD87) is a pleiotropic molecule. Eur. J. Biochem. 252:1998;185-193.
    • (1998) Eur. J. Biochem. , vol.252 , pp. 185-193
    • Dear, A.E.1    Metcalf, R.L.2
  • 7
    • 0029642314 scopus 로고
    • Prevention of prostate-cancer metastasis in vivo by a novel synthetic inhibitor of urokinase-type plasminigen activator (uPA)
    • Rabbani S. A., Harakidas P., Davidson D. J., Henkin J., Mazar A. P. Prevention of prostate-cancer metastasis in vivo by a novel synthetic inhibitor of urokinase-type plasminigen activator (uPA). Int. J. Cancer. 63:1995;840-845.
    • (1995) Int. J. Cancer , vol.63 , pp. 840-845
    • Rabbani, S.A.1    Harakidas, P.2    Davidson, D.J.3    Henkin, J.4    Mazar, A.P.5
  • 8
    • 0028821827 scopus 로고
    • Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor-associated angiogenesis, and metastasis to lung and liver in an athymic mouse model
    • Soff G. A., Sanderowitz J., Gately S., Verrusio E., Weiss I., Brem S., Kwaan H. C. Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor-associated angiogenesis, and metastasis to lung and liver in an athymic mouse model. J. Clin. Invest. 96:1995;2593-2600.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2593-2600
    • Soff, G.A.1    Sanderowitz, J.2    Gately, S.3    Verrusio, E.4    Weiss, I.5    Brem, S.6    Kwaan, H.C.7
  • 9
    • 0029113231 scopus 로고
    • Urokinase receptor is a multifunctional protein: Influence of receptor occupancy on macrophage gene expression
    • Rao N. K., Shi G.-P., Chapman H. A. Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression. J. Clin. Invest. 96:1995;465-474.
    • (1995) J. Clin. Invest. , vol.96 , pp. 465-474
    • Rao, N.K.1    Shi, G.-P.2    Chapman, H.A.3
  • 10
    • 0028305433 scopus 로고
    • Induction of cell migration by pro-urokinase binding to its receptor: Possible mechanisms for signal transduction in human epithelial cells
    • Busso N., Masur S. K., Lazega D., Waxman S., Ossowski L. Induction of cell migration by pro-urokinase binding to its receptor: Possible mechanisms for signal transduction in human epithelial cells. J. Cell Biol. 126:1994;259-270.
    • (1994) J. Cell Biol. , vol.126 , pp. 259-270
    • Busso, N.1    Masur, S.K.2    Lazega, D.3    Waxman, S.4    Ossowski, L.5
  • 12
    • 0029923744 scopus 로고    scopus 로고
    • Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect
    • Resnati M., Guttinger M., Valcamonica S., Sidenius N., Blasi F., Fazioli F. Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO J. 15:1996;1572-1582.
    • (1996) EMBO J. , vol.15 , pp. 1572-1582
    • Resnati, M.1    Guttinger, M.2    Valcamonica, S.3    Sidenius, N.4    Blasi, F.5    Fazioli, F.6
  • 13
    • 0030716909 scopus 로고    scopus 로고
    • Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598
    • Koshelnick Y., Ehart M., Hufnagl P., Heinrich P. C., Binder B. R. Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598. J. Biol. Chem. 272:1997;28563-28567.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28563-28567
    • Koshelnick, Y.1    Ehart, M.2    Hufnagl, P.3    Heinrich, P.C.4    Binder, B.R.5
  • 14
    • 0031983177 scopus 로고    scopus 로고
    • The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells
    • Dumler I., Weis A., Mayborodda O. A., Masch C., Jerke U., Haller H., Gulba D. C. The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells. J. Biol. Chem. 273:1998;315-321.
    • (1998) J. Biol. Chem. , vol.273 , pp. 315-321
    • Dumler, I.1    Weis, A.2    Mayborodda, O.A.3    Masch, C.4    Jerke, U.5    Haller, H.6    Gulba, D.C.7
  • 15
    • 0028338844 scopus 로고
    • Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro
    • Stahl A., Mueller B. M. Binding of urokinase to its receptor promotes migration and invasion of human melanoma cells in vitro. Cancer Res. 54:1994;3066-3071.
    • (1994) Cancer Res. , vol.54 , pp. 3066-3071
    • Stahl, A.1    Mueller, B.M.2
  • 16
    • 0025942415 scopus 로고
    • Involvement of urokinase and its receptor in the invasiveness of human prostatic carcinoma cell lines
    • Hoosein N. M., Boyd D. D., Hollas W. J., Mazar A., Henkin J., Chung L. W. K. Involvement of urokinase and its receptor in the invasiveness of human prostatic carcinoma cell lines. Cancer Commun. 3:1991;255-264.
    • (1991) Cancer Commun. , vol.3 , pp. 255-264
    • Hoosein, N.M.1    Boyd, D.D.2    Hollas, W.J.3    Mazar, A.4    Henkin, J.5    Chung, L.W.K.6
  • 18
    • 0031081425 scopus 로고    scopus 로고
    • Signaling through focal adhesion kinase
    • Hanks S. K., Polte T. R. Signaling through focal adhesion kinase. BioEssays. 19:1997;137-145.
    • (1997) BioEssays , vol.19 , pp. 137-145
    • Hanks, S.K.1    Polte, T.R.2
  • 20
    • 0028225445 scopus 로고
    • Plasminogen activators are involved in keratinocyte and fibroblast migration in wounded cultures in vitro
    • Quax P. H. A., Boxman I. L. A., Van Kesteren C. A. M., Verheijen J. H., Ponec M. Plasminogen activators are involved in keratinocyte and fibroblast migration in wounded cultures in vitro. Fibrinolysis. 8:1994;221-228.
    • (1994) Fibrinolysis , vol.8 , pp. 221-228
    • Quax, P.H.A.1    Boxman, I.L.A.2    Van Kesteren, C.A.M.3    Verheijen, J.H.4    Ponec, M.5
  • 22
    • 0029847191 scopus 로고    scopus 로고
    • Requirement of receptor-bound urokinase-type plasminogen activator for integrin αvβ5-directed cell migration
    • Yebra M., Parry G. C. N., Strömblad S., Mackman N., Rosenberg S., Mueller B. M., Cheresh D. A. Requirement of receptor-bound urokinase-type plasminogen activator for integrin αvβ5-directed cell migration. J. Biol. Chem. 271:1996;29393-29399.
    • (1996) J. Biol. Chem. , vol.271 , pp. 29393-29399
    • Yebra, M.1    Parry, G.C.N.2    Strömblad, S.3    Mackman, N.4    Rosenberg, S.5    Mueller, B.M.6    Cheresh, D.A.7
  • 24
    • 0032540943 scopus 로고    scopus 로고
    • The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells
    • Tang H., Kerins D. M., Hao Q., Inagami T., Vaughan D. E. The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cells. J. Biol. Chem. 273:1998;18268-18272.
    • (1998) J. Biol. Chem. , vol.273 , pp. 18268-18272
    • Tang, H.1    Kerins, D.M.2    Hao, Q.3    Inagami, T.4    Vaughan, D.E.5
  • 25
    • 0030772959 scopus 로고    scopus 로고
    • Role of focal adhesion kinase in integrin signaling
    • Guan J. L. Role of focal adhesion kinase in integrin signaling. Int. J. Biochem. Cell Biol. 29:1997;1085-1096.
    • (1997) Int. J. Biochem. Cell Biol. , vol.29 , pp. 1085-1096
    • Guan, J.L.1
  • 27
    • 0028331263 scopus 로고
    • Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells
    • Romer L. H., McLean N., Turner C. E., Burridge K. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Mol. Biol. Cell. 5:1994;349-361.
    • (1994) Mol. Biol. Cell , vol.5 , pp. 349-361
    • Romer, L.H.1    McLean, N.2    Turner, C.E.3    Burridge, K.4
  • 28
    • 0028018234 scopus 로고
    • Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds in culture
    • Gates R. E., King L. E. Jr., Hanks S. K., Nanney L. B. Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds in culture. Cell Growth Differ. 5:1994;891-899.
    • (1994) Cell Growth Differ. , vol.5 , pp. 891-899
    • Gates, R.E.1    King L.E., Jr.2    Hanks, S.K.3    Nanney, L.B.4
  • 29
    • 0029948080 scopus 로고    scopus 로고
    • Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn
    • Cary L. A., Chang J. F., Guan J.-L. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J. Cell Sci. 109:1996;1787-1794.
    • (1996) J. Cell Sci. , vol.109 , pp. 1787-1794
    • Cary, L.A.1    Chang, J.F.2    Guan, J.-L.3
  • 31
    • 0027448821 scopus 로고
    • Expression of focal adhesion kinase gene and invasive cancer
    • Weiner T. M., Liu E. T., Craven R. J., Cance W. G. Expression of focal adhesion kinase gene and invasive cancer. Lancet. 342:1993;1024-1025.
    • (1993) Lancet , vol.342 , pp. 1024-1025
    • Weiner, T.M.1    Liu, E.T.2    Craven, R.J.3    Cance, W.G.4
  • 34
    • 0027990414 scopus 로고
    • A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation dependent manner
    • Sakai R., Iwamatsu A., Hirano N., Ogawa S., Tanaka T., Mano H., Yazaki Y., Hirai H. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation dependent manner. EMBO J. 13:1994;3748-3756.
    • (1994) EMBO J. , vol.13 , pp. 3748-3756
    • Sakai, R.1    Iwamatsu, A.2    Hirano, N.3    Ogawa, S.4    Tanaka, T.5    Mano, H.6    Yazaki, Y.7    Hirai, H.8
  • 35
    • 0029664531 scopus 로고    scopus 로고
    • Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases
    • Vuori K., Hirai H., Aizawa S., Ruoslahti E. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: A role for Src family kinases. Mol. Cell. Biol. 16:1996;2606-2613.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2606-2613
    • Vuori, K.1    Hirai, H.2    Aizawa, S.3    Ruoslahti, E.4
  • 38
  • 39
    • 0028982346 scopus 로고
    • Plasmin abrogates αvβ5-mediated adhesion of a human keratinocyte cell line (HaCaT) to vitronectin
    • Reinartz J., Schafer B., Batrla R., Klein C. E., Kramer M. D. Plasmin abrogates αvβ5-mediated adhesion of a human keratinocyte cell line (HaCaT) to vitronectin. Exp. Cell Res. 220:1995;274-282.
    • (1995) Exp. Cell Res. , vol.220 , pp. 274-282
    • Reinartz, J.1    Schafer, B.2    Batrla, R.3    Klein, C.E.4    Kramer, M.D.5
  • 40
    • 0028569183 scopus 로고
    • Identification of the urokinase receptor as an adhesion receptor for vitronectin
    • Wei Y., Waltz D. A., Rao N., Drummond R. J., Rosenberg S., Chapman H. A. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J. Biol. Chem. 269:1994;32380-32388.
    • (1994) J. Biol. Chem. , vol.269 , pp. 32380-32388
    • Wei, Y.1    Waltz, D.A.2    Rao, N.3    Drummond, R.J.4    Rosenberg, S.5    Chapman, H.A.6
  • 41
    • 0030916129 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator receptors associate with β1 and β3 integrins of fibrosarcoma cells: Dependence on extracellular matrix components
    • Xue W., Mizukami I., Todd R. F. III, Petty H. R. Urokinase-type plasminogen activator receptors associate with β1 and β3 integrins of fibrosarcoma cells: dependence on extracellular matrix components. Cancer Res. 57:1997;1682-1689.
    • (1997) Cancer Res. , vol.57 , pp. 1682-1689
    • Xue, W.1    Mizukami, I.2    Todd R.F. III3    Petty, H.R.4
  • 42
    • 0030068772 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator receptor reversibly dissociates from complement receptor type 3 (αMβ2, CD11b/CD18) during neutrophil polarization
    • Kindzelskii A. L., Laska Z. O., Todd R. F. III, Petty H. R. Urokinase-type plasminogen activator receptor reversibly dissociates from complement receptor type 3 (αMβ2, CD11b/CD18) during neutrophil polarization. J. Immunol. 156:1996;297-309.
    • (1996) J. Immunol. , vol.156 , pp. 297-309
    • Kindzelskii, A.L.1    Laska, Z.O.2    Todd R.F. III3    Petty, H.R.4
  • 43
    • 0030881492 scopus 로고    scopus 로고
    • Proximity oscillations of complement type 4 (αxβ2) and urokinase receptors on migrating neutrophils
    • Kindzelskii A. L., Eszes M. M., Todd R. F. III, Petty H. R. Proximity oscillations of complement type 4 (αxβ2) and urokinase receptors on migrating neutrophils. Biophys. J. 73:1997;1777-1784.
    • (1997) Biophys. J. , vol.73 , pp. 1777-1784
    • Kindzelskii, A.L.1    Eszes, M.M.2    Todd R.F. III3    Petty, H.R.4
  • 44
    • 0032555894 scopus 로고    scopus 로고
    • Urokinase receptor (CD87) regulates leukocyte recruitment via β2 integrins in vivo
    • May A. E., Kanse S. M., Lund L. R., Gisler R. H., Imhof B. A., Preissner K. T. Urokinase receptor (CD87) regulates leukocyte recruitment via β2 integrins in vivo. J. Exp. Med. 188:1998;1029-1037.
    • (1998) J. Exp. Med. , vol.188 , pp. 1029-1037
    • May, A.E.1    Kanse, S.M.2    Lund, L.R.3    Gisler, R.H.4    Imhof, B.A.5    Preissner, K.T.6
  • 45
    • 0029932651 scopus 로고    scopus 로고
    • Integrins as promiscuous signal transduction devices III
    • Petty H. R., Todd R. F. Integrins as promiscuous signal transduction devices III. Immunol. Today. 17:1996;209-212.
    • (1996) Immunol. Today , vol.17 , pp. 209-212
    • Petty, H.R.1    Todd, R.F.2


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