RIP-β2-Microglobulin Transgene Expression Restores Insulitis, but not Diabetes, in β2-Microglobulinnull Nonobese Diabetic Mice

Journal of Immunology

Volumn 157, Issue 8, 1996, Pages 3688-3693

  Kay, Thomas W H ^a   Parker, Jennie L ^a   Stephens, Leigh A ^a   Thomas, Helen E ^a   Allison, Janette ^b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; HLA ANTIGEN CLASS 1; INSULIN;

ANIMAL; ARTICLE; C57BL MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; FEMALE; GENETICS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE SUBPOPULATION; MALE; METABOLISM; MOUSE; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PATHOLOGY; PROMOTER REGION; RAT; TRANSGENIC MOUSE;

ANIMALS; BETA 2-MICROGLOBULIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; LYMPHOCYTE SUBSETS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); RATS;

EID: 0030587871     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. + T cells. Science 248:1227.
2. + cytolytic T cells. Nature 344:742.
3. Raulet, D. H. 1994. MHC class I-deficient mice. Adv. Immunol. 55:381.
4. null mice are diabetes and insulitis resistant. Diabetes 43:505.
5. Sumida, T., M. Furukawa, A. Sakamoto, T. Namekawa, T. Maeda, M. Zijlstra, I. Iwamoto, T. Koike, S. Yoshida, H. Tomioka, and M. Taniguchi. 1994. Prevention of insulitis ami diabetes in beta 2-microglobulin-deficient non-obese diabetic mice. Int. Immunol. 6:1445.
6. Wicker, L. S., E. H. Leiter, J. A. Todd, R. J. Renjilian, E. Peterson, P. A. Fischer, P. L. Podolin, M. Zijlstra, R. Jaenisch, and L. B. Peterson. 1994. Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 43:500.
7. Katz, J., C. Benoist, and D. Mathis. 1993. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur. J. Immunol. 23:3358.
8. Muller, D., B. H. Koller, J. L. Whitton, K. E. LaPan, K. K. Brigman, and J. A. Frelinger. 1992. LCMV-specific, class II-restricted cytotoxic T cells in beta 2-microglobulin-deficient mice. Science 255:1576.
9. Bix, M., and D. Raulet. 1992. Functionally conformed free class I heavy chains exist on the surface of beta 2 microglobulin negative cells. J. Exp. Med. 176:829.
10. + cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 89:11381.
11. + T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I. J. Exp. Med. 179:661.
12. 2-microglobulin-negative, MHC class I-deficient mice in response to immunization with tumor cells. J. Immunol. 152:2087.
13. Kay, T. W., I. L. Campbell, L. Oxbrow, and L. C. Harrison. 1991. Overexpression of class I major histocompatibility complex accompanies insulitis in the non-obese diabetic mouse and is prevented by anti-interferon-gamma antibody. Diabetologia 34:779.
14. Ohashi, P. S. S. Oehen, K. Burki, H. Pircher, C. T. Ohashi, B. Odermatt, B. Malissen, R. M. Zinkernagel, and H. Hengartner. 1991. Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice. Cell 65:305.
15. Oldstone, M. B., M. Nerenberg, P. Southern, J. Price, and H. Lewicki. 1991. Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 65:319.
16. Larger, E., C. Becourt, J. F. Bach, and C. Boitard. 1995. Pancreatic islet beta cells drive T cell-immune responses in the nonobese diabetic mouse model. J. Exp. Med. 181:1635.
17. Allison, J., L. Malcolm, J. Culvenor, R. K. Bartholomeusz, K. Holmberg, and J. F. Miller. 1991. Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion Proc: Natl. Acad. Sci. USA 88:2070.
18. + T-lymphocytes. Diabetes 37:1108.
19. Lake, S. P., J. Anderson, J. Chamberlain, S. J. Gardner, P. R. Bell, and R. F. James. 1987. Bovine serum albumin density gradient isolation of rat pancreatic islets. Transplantation 43:805.
20. Eisenbarth, G. S., F. S. Walsh, and M. Nirenberg. 1979. Monoclonal antibody to a plasma membrane antigen of neurons. Proc. Natl. Acad. Sci. USA 76:4913.
21. Ozato, K., N. M. Mayer, and D. H. Sachs. 1982. Monoclonal antibodies to mouse major histocompatibility complex antigens. Transplantation 34:113.
22. Zijlstra, M., H. Auchincloss, Jr., J. M. Loring, C. M. Chase, P. S. Russell, and R. Jaenisch. 1992. Skin graft rejection by beta 2-microglobulin-deficient mice. J. Exp. Med. 175:885.
23. 2-microglobulin-deficient mice. J. Immunol. 153:595.
24. +/+ cells. J. Immunol. 154:6252.
25. Stephens, L. A., and T. W. H. Kay. 1995. Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse. Int. Immunol. 7:1885.
26. Wong, S., S. Guerder, I. Visintin, E. P. Reich, K. E. Swenson, R. A. Flavell, and C. Janeway, Jr. 1995. Expression of the co-stimulator molecule B7-1 in pancreatic beta-cells accelerates diabetes in the NOD mouse. Diabetes 44:326.
27. Norbury, C. C., L. J. Hewlett, A. R. Prescott, N. Shastri, and C. Watts. 1995. Class 1 MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. Immunity 3:783.
28. + T cells in the destruction of islet grafts by spontaneously diabetic mice. Proc. Natl. Acad. Sci. USA 88:527.
29. Markmann, J. F., H. Bassiri, N. M. Desai, J. S. Odorico, J. I. Kim, B. H. Koller, O. Smithies, and C. F. Barker. 1992. Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. Transplantation 54:1085.
30. + islet-specific T-cell clone. Diabetes 41:1603.
31. + islet-specific T cell clone. Science 249:1433.
32. Katz, J. D., B. Wang, K. Haskins, C. Benoist, and D. Mathis. 1993. Following a diabetogenic T cell from genesis through pathogenesis. Cell 74:1089.
33. Wong, F. S., I. Visintin, L. Wen, R. A. Flavell, and C. A. Janeway. 1996. CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 183:67.
34. Shizuru, J. A., C. Taylor-Edwards, B. A. Banks, A. K. Gregory, and C. G. Pathman. 1988. Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science 240:659.
35. Wicker, L. S., J. A. Todd, and L. B. Peterson. 1995. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13:179.
36. Itegami, H., Y. Kawaguchi, H. Ueda, M. Fukuda, K. Takakawa, Y. Fujioka, T. Fujisawa, K. Uchida, and T. Ogihara. 1993. MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3′ boundary of the diabetogenic region. Biochem. Biophys. Res. Commun. 192:677.
37. Honeyman, M. C., L. C. Harrison, B. Drummond, P. G. Colman, and B. D. Tait. 1995. Analysis of families at risk for insulin-dependent diabetes mellitus reveals that HLA antigens influence progression to clinical disease. Mol. Med. 1:576.
38. Fennessy, M., K. Metcalfe, G. A. Hitman, M. Niven, P. A. Biro, J. Tuomilehto. and E. Tuomilehto-Wolf. 1994. A gene in the HLA class I region contributes Io susceptibility to IDDM in the Finnish population: Childhood Diabetes in Finland (DiMe) Study Group. Diabetologia 37:937.
39. Nakanishi, K., T. Kobayashi, T. Murase, T. Nakatsuji, H. Inoko, K. Tsuji, and K. Kosaka. 1993. Association of HLA-A24 with complete beta-cell destruction in IDDM. Diabetes 42:1086.
40. Nakanishi, K., T. Kobayashi, H. Inoko, K. Tsuji, T. Murase, and K. Kosaka. 1995. Residual beta-cell function and HLA-a24 in IDDM: markers of glycemic control and subsequent development of diabetic retinopathy. Diabetes 44:1334.
41. Campbell, I. L., T. W. Kay, L. Oxbrow, and L. C. Harrison. 1991. Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87:739.
42. Sarvetnick, N., D. Liggitt, S. L. Pitts, S. E. Hansen, and T. A. Stewart. 1988. Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52:773.
43. Sarvetnick, N., J. Shizuru, D. Liggitt, L. Martin, B. McIntyre, A. Gregory, T. Parslow, and T. Stewart. 1990. Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma. Nature 346:844.
44. Ohashi, P. S., S. Gehen, P. Aichele, H. Pircher, B. Odermatt, P. Herrera, Y. Higuchi, K. Buerki, H. Hengartner, and R. M. Zinkernagel. 1993. Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha. J. Immunol. 150:5185.
45. Goes, N., T. Sims, J. Urmson, D. Vincent, V. Ramassar, and P. F. Halloran. 1995. Disturbed MHC regulation in the IFN-gamma knockout mouse: evidence for three states of MHC expression with distinct roles for IFN-γ. J. Immunol. 155:4559.
46. Kay, T. W., I. L. Campbell, and L. C. Harrison. 1991. Characterization of pancreatic T lymphocytes associated with beta cell destruction in the non-obese diabetic (NOD) mouse. J. Autoimmun. 4:263.