Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways

Neoplasia

Volumn 4, Issue 2, 2002, Pages 171-180

  Tian, Hui ^a   Faje, Alexander T ^a   Lee, Siu Lan ^a   Jorgensen, Timothy J ^a  

^a GEORGETOWN UNIVERSITY   (United States)

Author keywords

Cell cycle arrest; Chk1; p53; Radiation; UCN 01

Indexed keywords

7 HYDROXYSTAUROSPORINE; DNA; PHOSPHOTRANSFERASE; PROTEIN P21; PROTEIN P53; REGULATOR PROTEIN;

ARTICLE; CELL CYCLE; DNA CONTENT; DNA DAMAGE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RADIATION; RADIATION DOSE;

EID: 0036118391     PISSN: 15228002     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj/neo/7900219     Document Type: Article

References (51)

1. Radiation-induced cellular reproductive death and chromosome aberrations
2. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to CdK regulation through Cdc25
3. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms
4. Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells
5. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
6. (- / -) mice
7. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase
8. Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
9. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding
10. Replication checkpoint requires phosphorylation of the phosphatase cdc25 by Cds1 or Chk1
11. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site
12. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
13. Cell cycle-dependent and ATM-independent expression of human Chk1 kinase
14. The DNA damage response: Putting checkpoints in perspective
15. Requirement for p53 and p21 to sustain G2 arrest after DNA damage
16. 2/M checkpoint
17. 14-3-3 Proteins: Biological functions and domain structure
18. p21 is necessary for the p53-mediated G1 arrest in human cancer cells
19. 14-3-3σ is required to prevent mitotic catastrophe after DNA damage
20. 14-3-3 Sigma is a p53-regulated inhibitor of G2/M progression
21. A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis
22. WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis
23. Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis
24. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
25. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
26. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
27. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
28. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
29. An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage
30. Disruption of p53 in human cancer cells alters the responses to therapeutic agents
31. Cell-cycle arrest versus cell death in cancer therapy
32. Enhanced phosphorylation of p53 by ATM in response to DNA damage
33. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
34. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
35. p53 and ATM: Cell cycle, cell death, and cancer
36. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
37. Ionizing radiation exposure results in up-regulation of Ku70 via a p53/ataxia-telangiectasia-mutated protein-dependent mechanism
38. UCN-01: A potent abrogator of G2 checkpoint function in cancer cells with disrupted p53
39. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
40. Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
41. Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53
42. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
43. Association of Chk1 with 14-3-3 proteins is stimulated by DNA damage
44. WAF1, a potential mediator of p53 tumor suppression
45. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
46. p21 is a universal inhibitor of cyclin kinases
47. p53 involvement in control of G2 exit of the cell cycle: Role in DNA damage-induced apoptosis
48. Role of wild type p53 in the G2 phase: Regulation of the gamma-irradiation-induced delay and DNA repair
49. Modulation of protein kinase C in antitumor treatment
50. Relationship of p53 to the control of apoptotic cell death
51. Genetic determinants of p53-induced apoptosis and growth arrest