Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes

Journal of Experimental Medicine

Volumn 192, Issue 5, 2000, Pages 647-657

  Villunger, Andreas ^a   O'Reilly, Lorraine A ^a   Holler, Nils ^b   Adams, Jerry ^a   Strasser, Andreas ^a,c  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Activated protein kinase; Apoptosis; Bcl 2; Fas ligand; Granulocyte colony; P38 mitogen; Stimulating factor

Indexed keywords

FAS ANTIGEN; GRANULOCYTE COLONY STIMULATING FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; GRANULOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CELL SURVIVAL; FAS LIGAND PROTEIN; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTES; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0034605032     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.5.647     Document Type: Article

References (69)

1. The molecular control of granulocytes and macrophages
2. Novel trends in neutrophil structure, function and development
3. Phagocyte recognition of cells undergoing apoptosis
4. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products
5. Mcl-1 expression in human neutrophils: Regulation by cytokines and correlation with cell survival
6. The murine antiapoptotic protein A1 is induced in inflammatory macrophages and constitutively expressed in neutrophils
7. A1, a bcl-2 family member, prolongs cell survival and permits myeloid differentiation
8. Expression and function of the Fas receptor on human blood and tissue eosinophils
9. Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: Implications for the regulation of apoptosis in neutrophils
10. Involvement of two types of TNF receptor in TNF-α induced neutrophil apoptosis
11. Role of p38-mitogen-activated protein kinase in spontaneous apoptosis of human neutrophils
12. P38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils
13. Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils
14. The expression of Bcl-x is downregulated during differentiation of human hematopoietic progenitor cells along the granulocyte but not the monocyte/macrophage lineage
15. Al is a constitutive and inducible Bcl-2 homologue in mature human neutrophils
16. Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene
17. The expression of genes modulating programmed cell death in normal human polymorphonuclear neutrophils
18. Spontaneous and Fas-induced apoptotic cell death in aged neutrophils
19. Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia
20. Mice deficient in fas ligand (gld) or fas (lpr) show few alterations in granulopoiesis
21. Regulation and function of the JNK subgroup of MAP kinases
22. Constitutive bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival
23. Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)
24. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity
25. Rapid hybridoma screening method for the identification of monoclonal antibodies to low abundance cytoplasmic proteins
26. The pro-apoptotic BH3-only protein Bim is expressed in hemopoietic, epithelial, neuronal and germ cells
27. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
28. Down-regulation of Fas ligand by shedding
29. Fas ligand - Caught between Scylla and Charybdis
30. Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice
31. Two CD95 (APO-1/Fas) signaling pathways
32. A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection
33. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice
34. Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of fas or FADD/MORT1 signaling: Implications for cancer therapy
35. A dominant interfering mutant of FADD/ Mort1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
36. Bcl-2, Bcl-X(L) and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death
37. Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma
38. Bcl-2 blocks degranulation but not fas-based cell-mediated cytotoxicity
39. Involvement of the CD95 (APO-1/Fas) receptor/ ligand system in drug-induced apoptosis in leukemia cells
40. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
41. Requirements for ceramide-initiated SAPK/JNK signailing in stres-induced apoptosis
42. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
43. P38 mitogen-activated protein kinase inhibitors -mechanisms and therapeutic potentials
44. Cytokine-specific activation of distinct mitogen-activated protein kinase subtype cascades in human neutrophils stimulated by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-alpha
45. Soluble Fas ligand is chemotactic for human neutrophilic polymorphonuclear leukocytes
46. Chemotactic activity of soluble Fas ligand against phagocytes
47. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
48. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens
49. Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice
50. Bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages
51. Transfection with a bcl-2 expression vector protects transplanted bone marrow from chemotherapy-induced myelosuppression
52. Drug-induced apoptosis is associated with enhanced Fas (Apo-1/CD95) ligand expression but occurs independently of Fas (Apo-1/CD95) signaling in human T-acute lymphatic leukemia cells
53. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
54. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
55. Hemotoxicity by prolonged etoposide administration to mice can be prevented by simultaneous growth factor therapy
56. Priming with G-CSF effectively enhances low-dose Ara-C-induced in vivo apoptosis in myeloid leukemia cells
57. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
58. Massive cell death of immature hematopoietic cells and neurons in Bcl-x deficient mice
59. Apoptosis regulator Bcl-w is essential for spermatogenesis but appears otherwise redundant
60. Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: A general mechanism to accumulate effector cells in inflammation
61. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
62. The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
63. Selective activation and functional significance of p38α mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils
64. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
65. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
66. Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes
67. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis
68. Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase
69. Deficiency of the stress kinase p38α results in embryonic lethality: Characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells