CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Aβ-induced cortical neuron apoptosis

Journal of Neurochemistry

Volumn 77, Issue 3, 2001, Pages 849-863

  Bozyczko Coyne, Donna ^a   O'Kane, Teresa M ^a   Wu, Zhi Liang ^a   Dobrzanski, Pawel ^a   Murthy, Seetha ^a   Vaught, Jeffry L ^a   Scott, Richard W ^a  

^a CEPHALON INC   (United States)

Author keywords

Beta amyloid; c Jun N terminal kinase; Caspase 3; CEP 1347; Cytochrome c; MKK4

Indexed keywords

AMYLOID BETA PROTEIN; CALPAIN; CASPASE 3; CEP 1347; CYCLIN D1; CYTOCHROME C; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FETUS; GENE INDUCTION; GENETIC TRANSCRIPTION; IN VITRO STUDY; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CALPAIN; CARBAZOLES; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CYTOCHROME C GROUP; CYTOPLASM; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; L-LACTATE DEHYDROGENASE; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEURONS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0035019371     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00294.x     Document Type: Article

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