Mayhem of the multiple mechanisms: Modelling neurodegeneration in prion disease

Journal of Neurochemistry

Volumn 82, Issue 2, 2002, Pages 209-215

  Brown, David R ^a  

^a University of Bath   (United Kingdom)

Author keywords

Apoptosis; Copper; Microglia; Oxidative stress; Prion; Toxicity

Indexed keywords

GLYCOPROTEIN; PRION PROTEIN;

ASTROCYTE; DEATH; HUMAN; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROTOXICITY; PRION DISEASE; PRIORITY JOURNAL; SHORT SURVEY;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; NEURODEGENERATIVE DISEASES; NEURONS; PEPTIDE FRAGMENTS; PRION DISEASES; PRIONS; PRPC PROTEINS;

EID: 0036068963     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01004.x     Document Type: Short Survey

References (74)

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5. Comment on: Neurotoxicity of prion protein peptide 106-126 not confirmed
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13. Different requirements for the neurotoxicity of fragments of PrP and β-amyloid
14. Cellular effects of a neurotoxic prion protein peptide are related to its β-sheet content
15. A prion protein fragment interacts with PrP-deficient cells
16. Consequences of manganese replacement of copper for prion protein function and proteinase resistance
17. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
18. Mice devoid of PrP are resistant to scrapie
19. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of β-amyloid and prion protein
20. Toxicity of novel C-terminal prion protein fragments and peptides harbouring disease-related C-terminal mutations
21. Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologous to residues 106-126 of the prion protein
22. PrP fragment 106-126 is toxic to cerebral endothelial cells expressing PrP (c)
23. Neurotrophin p75 receptor is involved in neuronal damage by prion peptide-(106-126)
24. In vivo cytotoxicity of prion protein fragment PrP106-126
25. The stimulation of inducible nitric-oxide synthase by the prion protein fragment 106-126 in human microglia is tumor necrosis factor-alpha-dependent and involves p38 mitogen-activated protein kinase
26. Intracellular rise through 1-type calcium channels, as molecular mechanism for prion protein fragment 106-126-induced astroglial proliferation
27. Neurotoxicity of a prion protein fragment
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29. Role of microglia in neuronal cell death in prion disease
30. Cellular prion protein binds laminin and mediates neurogenesis
31. Prion peptide 106-126 modulates the aggregation of cellular prion protein and induces the synthesis of potentially neurotoxic transmembrane PrP
32. Evidence for oxidative stress in experimental prion disease
33. Neurotoxicity of the putative transmembrane domain of the prion protein
34. Evidence of specific interaction between cellular prion protein and vitronectin
35. A transmembrane form of the prion protein in neurodegenerative disease
36. Transmissible and genetic prion diseases share a common pathway of neurodegeneration
37. Nonionic detergents induce dimerization among members of the Bcl-2 family
38. The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide PrP106-126
39. Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
40. The cellular prion protein colocalizes with the dystroglycan complex in the brain
41. Prion peptide fragment PrP[106-126] forms distinct cation channel types
42. Channel activity of deamidated isoforms of prion protein fragment 106-126 in plnar lipid bilayers
43. Neurotoxicity prion peptide 106-126 not confirmed
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45. The neurotoxic prion peptide PrP106-126 is a chemotactic agonist for the G-protein-coupled receptor formyl peptide receptor-like I
46. Biochemical interaction between cellular prion protein and extendin
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49. Sc)-induced toxicity in rat cortical cell cultures
50. Interaction of prion peptide HuPrP106-126 with nucleic acid
51. Prion protein fragment PrP106-126 induces apoptosis via mitochondrial disruption in human neuronal SH-SY5Y cells
52. A cellular gene encodes scrapie PrP 27-30 protein
53. Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126)
54. A nonfibrillar form of the fusogenic prion protein fragment [118-135] induces apoptotic cell death in rat cortical neurons
55. Novel proteinaceous infectious particles cause scrapie
56. Prions
57. Prion diseases and neurodegeneration
58. The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells
59. Prion protein fragment 106-126 differentially induces heme oxygenase-1 mRNA in cultured neurons and astroglial cells
60. The role of prion protein structure and aggregation in toxicity and membrane binding
61. A neurotoxic and gliotrophic fragment of the prion protein increases plasma membrane microviscosity
62. Molecular determinants of the physiochemical properties of a critical prion protein region comprising residues 106-126
63. Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions
64. Differential release of cellular and scrapie prion protein from cellular membranes of phosphatidylinositol specific phospholipase C
65. Most pathogenic mutations do not alter the membrane topology of the prion protein
66. Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126
67. Prion protein of 106 residues creates an artificial transmission barrier for prion replication in transgenic mice
68. Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro
69. Apoptotic cell death and impairment of 1-type voltage-sensitive calcium channel activity in the rat cerebellar granule cells treated with the prion protein fragment 106-126
70. Regulation of intracellular free calcium levels by the cellular prion protein
71. Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons
72. Characterization of microglial response in murine scrapie
73. Oxidative impairment in scrapie-infected mice is associated with brain metal perturbations and altered ani-oxidantion activities
74. Identification of candidiate proteins binding to prion protein