Prion peptide fragment PrP[106-126] forms distinct cation channel types

Journal of Neuroscience Research

Volumn 62, Issue 1, 2000, Pages 120-133

  Richter Landsberg, Christiane ^a   Gorath, Michaela ^a   Trojanowski, John Q ^b   Lee, Virginia M Y ^b  

^a UNIVERSITY OF OLDENBURG   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cation channels; Channel forming peptides; Heterogeneous channels; Prions; Signal transduction

Indexed keywords

CATION CHANNEL; GLUTATHIONE DISULFIDE; LIPOSOME; OXIDIZING AGENT; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; POTASSIUM CHANNEL BLOCKING AGENT; PRION PROTEIN; PRP[106-126]PROTEIN; TETRYLAMMONIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG SYNTHESIS; ION CONDUCTANCE; ION CURRENT; ION TRANSPORT; KINETICS; LIPID BILAYER; MEMBRANE TRANSPORT; NEUROPATHOLOGY; PATHOGENESIS; PEPTIDE ANALYSIS; PRION DISEASE; PRIORITY JOURNAL; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

CATIONS, MONOVALENT; DITHIOTHREITOL; ELECTRIC CONDUCTIVITY; GLUTATHIONE DISULFIDE; ION CHANNELS; KINETICS; LIPID BILAYERS; LIPOSOMES; MEMBRANE POTENTIALS; OXIDANTS; PEPTIDE FRAGMENTS; POTASSIUM CHANNEL BLOCKERS; PRIONS; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; TETRAETHYLAMMONIUM;

EID: 0033774525     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20001001)62:1<120::AID-JNR13>3.0.CO;2-2     Document Type: Article

References (30)

1. Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: Blockade by tromethamine and aluminum
2. JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial and bilayer measurements and for correcting junction potential measurements
3. Theoretical analysis of the implication of PrP in neuronal death during transmissible subacute spongiform encephalopathics: Hypothesis of a PrP oligomeric channel
4. Fitting and statistical analysis of single-channel recording
5. Conformation polymorphism of the amyloidogenic and neurotoxic peptide homologous to the residues 106-126 of the prion protein
6. Intracellular calcium rise through L-type calcium channels, as molecular mechanism for the prion protein fragment 106-126 induced astroglial proliferation
7. Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line
8. A transmembrane form of the prion protein in neurodegenerative disease
9. Transmissible and genetic prion diseases share a common pathway of neurodegeneration
10. Alzheimer amyloid abeta1-42 channels: Effects of solvent, pH, and Congo Red
11. Breech-birth prions
12. Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein
13. Alzheimer's disease β-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in hypothalamic GnRH neuronal cell line
14. Characteristic of two types of chloride channel in sarcoplasmic reticulum vesicles from rabbit skeletal muscle
15. Vagaries of artificial bilayers and gating modes of the SCl channel from the sarcoplasmic reticulum muscle
16. - channels
17. Neurotoxicity of prion peptide 106-126 not confirmed
18. Channel formation by a neurotoxic prion protein fragment
19. A single amino acid alteration (101L) introduced into routine PrP dramatically alters incubation time of transmissible spongiform encephalopathy
20. Infectivity and host responses in Creutzfeldt-Jakob disease
21. Reported channel formation by prion protein fragment 106-126 in planar lipid bilayer cannot be reproduced
22. 2+-induced fusion of fragmented sarcoplasmic reticulum with artificial planar bilayers
23. The conformational preference of gramicidin channels is a function of lipid bilayer thickness
24. Measuring kinetics of complex single ion channel data using mean-variance histograms
25. Molecular biology and pathogenesis of prion diseases
26. Prion protein biology
27. Spontaneous deamidation and isomerizarion of Asn108 in prion peptide and in full-length prion protein
28. Activation of microglial cells by PrP and -amyloid fragments raises intracellular calcium through L-type voltage-sensitive channels
29. Immunochemical, molecular genetic, and transmission studies on a case of Gerstmann-Straussler-Scheinker syndrome
30. Modelling charge interactions in prion protein: Predictions for pathogenesis