The cellular prion protein colocalizes with the dystroglycan complex in the brain

Journal of Neurochemistry

Volumn 75, Issue 5, 2000, Pages 1889-1897

  Keshet, Gilmor I ^a,b   Bar Peled, Osnat ^a,b   Yaffe, David ^a,b   Nudel, Uri ^a,b   Gabizon, Ruth ^a,b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Dystrophin; Glycoprotein complex; Neuronal nitric oxide synthase; Prion protein

Indexed keywords

ALPHA TUBULIN; BETA ACTIN; DYSTROGLYCAN; DYSTROPHIN; GLYCOPROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; NITRIC OXIDE SYNTHASE; PRION PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; IMMUNOPRECIPITATION; MEMBRANE BINDING; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SEQUENCE ANALYSIS;

ACTINS; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; BRAIN; CELL FRACTIONATION; CEREBELLUM; CYTOSKELETAL PROTEINS; DETERGENTS; DYSTROGLYCANS; GLYCOSYLPHOSPHATIDYLINOSITOLS; MACROMOLECULAR SUBSTANCES; MEMBRANE GLYCOPROTEINS; MEMBRANE MICRODOMAINS; MICE; NERVE TISSUE PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; POLYETHYLENE GLYCOLS; PRECIPITIN TESTS; PRPC PROTEINS; SYNAPTOPHYSIN; TUBULIN;

ANIMALIA;

EID: 0033793094     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0751889.x     Document Type: Article

References (51)

1. NMDA-R1 subunit of the cerebral cortex co-localizes with neuronal nitric oxide synthase at pre- and postsynaptic sites and in spines
2. Prion protein isoforms, a convergence of biological and structural investigations
3. Different dystrophin-like complexes are expressed in neurons and glia
4. Nitric oxide: A physiologic messenger molecule
5. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains
6. Altered toxicity of the prion protein peptide PrP106-126 carrying the Ala(117) → Val mutation
7. Effects of copper on survival of prion protein knockout neurons and glia
8. Normal prion protein has an activity like that of superoxide dismutase
9. Expression of Dp71 in Muller glial cells: A comparison with utrophin- and dystrophin-associated proteins
10. Mossy fibre reorganization in the hippocampus of prion protein null mice
11. Prion protein is necessary for normal synaptic function
12. Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering
13. Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle
14. Plasma membrane caveolae mediate the efflux of cellular free cholesterol
15. Rabbit brain and muscle isoforms containing the carboxy-terminal domain of 427 kDa skeletal muscle dystrophin exhibit similar biochemical properties
16. Interaction of neuronal nitric-oxide synthase and phosphofructokinase-M
17. Immunoaffinity purification and neutralization of scrapie prion infectivity
18. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: Implications for nitric oxide signaling
19. Differential expression of syntrophins and analysis of alternatively spliced dystrophin transcripts in the mouse brain
20. Severe, early and selective loss of a subpopulation of GABAergic inhibitory neurons in experimental transmissible spongiform encephalopathies
21. Interaction of neuronal nitric-oxide synthase with alpha1-syntrophin in rat brain
22. Subcellular localization and characterization of neuronal nitric oxide synthase
23. Evidence of presynaptic location and function of the prion protein
24. Patch-clamp analysis of synaptic transmission to cerebellar Purkinje cells of prion protein knockout mice
25. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins
26. Scrapie-infected mice and PrP knockout mice share abnormal localization and activity of neuronal nitric oxide synthase
27. Detection of dystrophin in the postsynaptic density of rat brain and deficiency in a mouse model of Duchenne muscular dystrophy
28. Nitric oxide in skeletal muscle
29. The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system
30. A 71-kilodalton protein is a major product of the Duchenne muscular dystrophy gene in brain and other nonmuscle tissues
31. Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: Implications for caveolae localization
32. Functionally different GPI proteins are organized in different domains on the neuronal surface
33. β-Dystroglycan: Subcellular localisation in rat brain and detection of a novel immunologically related, postsynaptic density-enriched protein
34. Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform
35. Localization of the DMDL gene-encoded dystrophin-related protein using a panel of nineteen monoclonal antibodies: Presence at neuromuscular junctions, in the sarcolemma of dystrophic skeletal muscle, in vascular and other smooth muscles, and in proliferating brain cell lines
36. Central GABAergic innervation of neurointermediate pituitary lobe: Biochemical and immunocytochemical study in the rat
37. Characterization of PrP binding proteins
38. Identification of cellular proteins binding to the scrapie prion protein
39. 2+ inhibit nitric-oxide synthase through an interaction with the reductase domain
40. Molecular biology of prion diseases
41. Characterization and cell type distribution of a novel, major transcript of the Duchenne muscular dystrophy gene
42. The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells
43. A one-step purification of membrane proteins using a high efficiency immunomatrix
44. Chimeric prion protein expression in cultured cells and transgenic mice
45. Rapid detection of Creutzfeldt-Jakob disease and scrapie prion proteins
46. A C-terminal-truncated PrP isoform is present in mature sperm
47. Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae
48. Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells
49. Dystroglycan in the cerebellum is a laminin alpha 2-chain binding protein at the glial-vascular interface and is expressed in Purkinje cells
50. Multiple products of the Duchenne muscular dystrophy gene
51. Identification of candidate proteins binding to prion protein