The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126

Journal of Neurochemistry

Volumn 73, Issue 4, 1999, Pages 1557-1565

  Jobling, Michael F ^a,b   Stewart, Leanne R ^a,b   White, Anthony R ^a,b   McLean, Catriona ^a,b   Friedhuber, Anna ^a,b   Maher, Fran ^a,b   Beyreuther, Konrad ^c   Masters, Colin L ^a,b   Barrow, Colin J ^a   Collins, Steven J ^a,b   Cappai, Roberto ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Sheet conformation; Amyloid; Creutzfeldt; Fibrillogenesis; Jakob disease; Neurotoxicity; Peptide aggregation; Turbidometry

Indexed keywords

PRION PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CIRCULAR DICHROISM; HUMANS; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NEPHELOMETRY AND TURBIDIMETRY; NEURONS; NEUROTOXINS; PEPTIDE FRAGMENTS; PEPTIDES; PRIONS; PROTEIN STRUCTURE, SECONDARY; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032820644     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0731557.x     Document Type: Article

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