Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in cerebellar granule cells treated with the prion protein fragment 106-126

Neurobiology of Disease

Volumn 7, Issue 4, 2000, Pages 299-309

  Thellung, Stefano ^a   Florio, Tullio ^b   Villa, Valentina ^a   Corsaro, Alessandro ^a   Arena, Sara ^a   Amico, Carolina ^c   Robello, Mauro ^c   Salmona, Mario ^d   Forloni, Gianluigi ^d   Bugiani, Orso ^e   Tagliavini, Fabrizio ^e   Schettini, Gennaro ^a  

^a CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e DEPARTMENT OF NEUROSURGERY   (Italy)

Author keywords

Apoptosis; L type voltage sensitive calcium channels; Nicardipine; Prion protein

Indexed keywords

CALCIUM CHANNEL; NICARDIPINE; PRION PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN DISEASE; CEREBELLUM; GRANULE CELL; NERVE DEGENERATION; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; RAT;

EID: 0033826141     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0301     Document Type: Article

References (39)

1. Pharmacological types of calcium channels and their modulation by baclofen in cerebellar granules
2. Prion protein peptide neurotoxicity can be mediated by astrocytes
3. A neurotoxic prion protein fragment enhances proliferation of microglia but not astrocytes in culture
4. Role of microglia and host prion protein in neurotoxicity of prion protein fragment
5. A prion protein fragment primes type I astrocytes to proliferation signals from microglia
6. Precise targeting of the sialoglycoprotein PrP and vacuolar degeneration in mouse scrapie
7. Truncated forms of the human prion protein in normal brain and in prion diseases
8. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins
9. Changes in the localization of brain prion proteins during scrapie infection
10. Conformational polymorphism of the amyloidogenic and neurotoxic peptide homologues to residues 106-126 of the prion protein
11. Nuclear DNA fragmentation in Creutzfeldt-Jacob disease: Does a mere positive in situ nuclear end-labeling indicated apoptosis?
12. Intracellular calcium rise through the L-type calcium channel, as molecular mechanism for prion protein fragment 106-126-induced astroglial proliferation
13. Prion protein fragment 106-126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line
14. Neurotoxicity of a prion protein fragment
15. A neurotoxic prion protein fragment induces rat astroglial proliferation and hypertrophy
16. Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, IGF-I through distinct mechanisms of action: The involvement of intracellular calcium and RNA synthesis
17. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture
18. Role of microglia in neuronal cell death in prion disease
19. Neuronal apoptosis in Creutzfeldt-Jakob disease
20. A new generation of calcium indicators with greatly improved fluorescence properties
21. The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126
22. Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation
23. Cell death in prion disease
24. Autoradiographic localization and depolarization-induced release of acidic amino acids in differentiating cerebellar granule cell cultures
25. Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoforms. J. Biol. Chem
26. Conversion of α-helices into β-sheets features in the formation of the scrapie prion proteins
27. Chemistry and biology of prions
28. Prions
29. NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231)
30. Regulation of GABAA receptor in cerebellar granule cells in culture: Differential involvement of kinase activities
31. β25-35 alters calcium homeostasis and induces neurotoxicity in cerebellar granule cells
32. 2+ homeostasis and rescues cortical neurons from apoptotic death
33. Molecular characteristics of a protease resistant amyloidogenic and neurotoxic peptide homologous to residue 106-126 of the prion protein
34. Activation of microglial cells by PrP and beta-amyloid fragments raises intracellular calcium through L-type voltage sensitive calcium channels
35. Synthetic peptides homologuos to prion protein residues 106-147 form amyloid-like fibrils in vitro
36. Prion propagation in mice expressing human and chimeric PrP trans-genes implicates the interaction of cellular PrP with another protein
37. Nuclear DNA fragmentation and immune reactivity in bovine spongiform encephalopathy
38. PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie
39. NMR solution structure of the human prion protein