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Volumn 40, Issue 27, 2001, Pages 8073-8084

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126

(14) Jobling, M F a,e Huang, X b Stewart, L R a Barnham, K J c Curtain, C d Volitakis, I a Perugini, M a White, A R a Cherny, R A a Masters, C L a Barrow, C J a Collins, S J a Bush, A I a,b Cappai, R a

a UNIVERSITY OF MELBOURNE (Australia)

b MASSACHUSETTS GENERAL HOSPITAL (United States)

c CSIRO (Australia)

d MONASH UNIVERSITY (Australia)

e FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ABNORMAL FORMS;

AGGLOMERATION; COPPER; MUTAGENESIS; POLYPEPTIDES; PROTEINS; TOXICITY; TURBIDIMETERS;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; BUFFER; CHELEX 100; COPPER ION; HISTIDINE; ION EXCHANGE RESIN; METHIONINE; MUTANT PROTEIN; PRION PROTEIN; PRION PROTEIN[106-126]; UNCLASSIFIED DRUG; ZINC ION;

ACETYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; ATOMIC EMISSION SPECTROMETRY; BIOPHYSICS; ELECTRON SPIN RESONANCE; METAL BINDING; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; TURBIDIMETRY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATION EXCHANGE RESINS; CELLS, CULTURED; CEREBELLUM; CHELATING AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; COPPER; ELECTRON SPIN RESONANCE SPECTROSCOPY; HISTIDINE; HUMANS; MASS SPECTROMETRY; METHIONINE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEPHELOMETRY AND TURBIDIMETRY; NEURONS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PRIONS; PROTEIN STRUCTURE, SECONDARY; RESINS, SYNTHETIC; ULTRACENTRIFUGATION; ZINC;

EID: 0035838471 PISSN: 00062960 EISSN: None Source Type: Journal
DOI: 10.1021/bi0029088 Document Type: Article

Times cited : (253)

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