Prion Protein Fragment PrP-(106-126) Induces Apoptosis via Mitochondrial Disruption in Human Neuronal SH-SY5Y Cells

Journal of Biological Chemistry

Volumn 276, Issue 47, 2001, Pages 43516-43523

  O'Donovan, Conor N ^a   Tobin, Deirdre ^a   Cotter, Thomas G ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CALCIUM; CELLS;

APOPTOSIS; SYNTHETIC PEPTIDES;

PROTEINS;

CASPASE INHIBITOR; PRION PROTEIN; PRION PROTEIN FRAGMENT PRP [106-126]; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; CALCIUM; CALPAIN; PEPTIDE FRAGMENT; PRION PROTEIN (106 126); PRION PROTEIN (106-126);

APOPTOSIS; ARTICLE; BETA SHEET; BOVINE SPONGIFORM ENCEPHALOPATHY; CALCIUM CELL LEVEL; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; DEGENERATIVE DISEASE; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; GENE DISRUPTION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; NERVE CELL; NEUROBLASTOMA; NEUROPIL; PRIORITY JOURNAL; SCRAPIE; CELL CULTURE; HOMEOSTASIS; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY; PRION;

BOVINAE;

APOPTOSIS; CALCIUM; CALPAIN; HOMEOSTASIS; HUMANS; MITOCHONDRIA; NEURONS; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PRIONS; TUMOR CELLS, CULTURED;

EID: 0035941307     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103894200     Document Type: Article

References (75)

1. Masters, C. L., and Richardson, E. P., Jr. (1978) Brain 101, 333-344
2. Mikol, J. (1999) Biomed. Pharmacother. 53, 19-26
3. Prusiner, S. B. (1991) Science 252, 1515-1522
4. Prusiner, S. B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13363-13383
5. Pauly, P. C., and Hariis, D. A. (1998) J. Biol. Chem. 273, 33107-33110
6. Ruiz, F. H., Silva, E., and Inestrosa, N. C. (2000) Biochem. Biophys. Res. Commun. 269, 491-495
7. Mouillet-Richard, S., Ermonval, M., Chebassier, C., Laplanche, J. L., Lehmann, S., Launay, J. M., and Kellermann, O. (2000) Science 289, 1925-1928
8. Bueler, H., Aguzzi, A., Sailer, A., Greiner, R. A., Autenried, P., Aguet, M., and Weissmann, C. (1993) Cell 73, 1339-1347
9. Gorman, A. M., McGowan, A., O'Neill, C., and Cotter, T. (1996) J. Neurol. Sci. 139, 45-52
10. Fairbairn, D. W., Carnahan, K. G., Thwaits, R. N., Grigsby, R. V., Holyoak, G. R., and O'Neill, K. L. (1994) FEMS Microbiol. Lett. 115, 341-346
11. Giese, A., Groschup, M. H., Hess, B., and Kretzschmar, H. A. (1995) Brain Pathol. 5, 213-221
12. Gray, F., Chretien, F., Adle-Biassette, H., Dorandeu, A., Ereau, T., Delisle, M. B., Kopp, N., Ironside, J. W., and Vital, C. (1999) J. Neuropathol. Exp. Neurol. 58, 321-328
13. Forloni, G., Angeretti, N., Chiesa, R., Monzani, E., Salmona, M., Bugiani, O., and Tagliavini, F. (1993) Nature 362, 543-546
14. Brown, D. R., Schmidt, B., and Kretzschmar, H. A. (1996) Nature 380, 345-347
15. Florio, T., Thellung, S., Amico, C., Robello, M., Salmona, M., Bugiani, O., Tagliavini, F., Forloni, G., and Schettini, G. (1998) J. Neurosci. Res. 54, 341-352
16. Ettaiche, M., Piehot, R., Vincent, J. P., and Chabry, J. (2000) J. Biol. Chem. 275, 36487-36490
17. Tagliavini, F., Prelli, F., Ghiso, J., Bugiani, O., Serban, D., Prusiner, S. B., Farlow, M. R., Ghetti, B., and Frangione, B. (1991) EMBO J. 10, 513-519
18. Tagliavini, F., Prelli, F., Verga, L., Giaccone, G., Sarma, R., Gorevic, P., Ghetti, B., Passerini, F., Ghibaudi, E., and Forloni, G. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 9678-9682
19. Chen, S. G., Teplow, D. B., Parchi, P., Teller, J. K., Gambetti, P., and Autilio-Gambetti, L. (1995) J. Biol. Chem. 270, 19173-19180
20. Baumann, M. H., Kallijarvi, J., Lankinen, H., Soto, C., and Haltia, M. (2000) Biochem. J. 349, 77-84
21. McGahon, A. J., Martin, S. J., Bissonnette, R. P., Mahboudi, A., Shi, Y., Mogil, R. J., Nishioka, W. K., and Green, D. R. (1995) Methods Cell Biol. 46, 153-185
22. Salvioli, S., Ardizzoni, A., Franceschi, C., and Cossarizza, A. (1997) FEBS Lett. 411, 77-82
23. Aebi, H. (1984) Methods in Enzymology, Vol. 105, pp. 121-126, Academic Press, Inc., Orlando, FL
24. Hope, J., Shearman, M. S., Baxter, H. C., Chong, A., Kelly, S. M., and Price, N. C. (1996) Neurodegeneration 5, 1-11
25. Carmody, R. J., and Cotter, T. G. (1998) Sepsis 2, 9-19
26. Bruce-Keller, A. J., Begley, J. G., Fu, W., Butterfield, D. A., Bredesen, D. E., Hutchins, J. B., Hensley, K., and Mattson, M. P. (1998) J. Neurochem. 70, 31-39
27. Kitada, S., Andersen, J., Akar, S., Zapata, J. M., Takayama, S., Krajewski, S., Wang, H. G., Zhang, X., Bullrich, F., Croce, C. M., Rai, K., Hines, J., and Reed, J. C. (1998) Blood 91, 3379-3389
28. Suzuki, M., Youle, R. J., and Tjandra, N. (2000) Cell 103, 645-654
29. Kirsch, D. G., Doseff, A., Chau, B. N., Lim, D. S., de Souza-Pinto, N. C., Hansford, R., Kastan, M. B., Lazebnik, Y. A., and Hardwick, J. M. (1999) J. Biol. Chem. 274, 21155-21161
30. Verhaegen, S., McGowan, A. J., Brophy, A. R., Fernandes, R. S., and Cotter, T. G. (1995) Biochem. Pharmacol. 50, 1021-1029
31. Slater, A. F. G., Stefan, C., Nobel, I., van den Dobbelsteen, D. J., and Orrenius, S. (1996) Cell Death Differ. 3, 57-62
32. Ray, S. K., Wilford, G. G., Matzelle, D. C., Hogan, E. L., and Banik, N. L. (1999) Ann. N. Y. Acad. Sci. 890, 261-269
33. Ishihara, I., Minami, Y., Nishizaki, T., Matsuoka, T., and Yamamura, H. (2000) Neurosci. Lett. 279, 97-100
34. Debiasi, R. L., Squier, M. K., Pike, B., Wynes, M., Dermody, T. S., Cohen, J. J., and Tyler, K. L. (1999) J. Virol. 73, 695-701
35. Brown, D. R., Schmidt, B., and Kretzschmar, H. A. (1997) Int. J. Dev. Neurosci. 15, 961-972
36. Rymer, D. L., and Good, T. A. (2000) J. Neurochem. 75, 2536-2545
37. Cossarizza, A., Kalashnikova, G., Grassilli, E., Chiappelli, F., Salvioli, S., Capri, M., Barbieri, D., Troiano, L., Monti, D., and Franceschi, C. (1994) Exp. Cell Res. 214, 323-330
38. Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., Macho, A., Hirsch, T., Susin, S. A., Petit, P. X., Mignotte, B., and Kroemer, G. (1995) J. Exp. Med. 182, 367-377
39. Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D. R., Aebersold, R., Siderovski, D. P., Penninger, J. M., and Kroemer, G. (1999) Nature 397, 441-446
40. Larochette, N., Decaudin, D., Jacotot, E., Brenner, C., Marzo, I., Susin, S. A., Zamzami, N., Xie, Z., Reed, J., and Kroemer, G. (1999) Exp. Cell Res. 249, 413-421
41. Zamzami, N., Marzo, I., Susin, S. A., Brenner, C., Larochette, N., Marchetti, P., Reed, J., Kofler, R., and Kroemer, G. (1998) Oncogene 16, 1055-1063
42. Perkins, C. L., Fang, G., Kim, C. N., and Bhalla, K. N. (2000) Cancer Res. 60, 1645-1653
43. Allen, R. T., Cluck, M. W., and Agrawal, D. K. (1998) Cell. Mol. Life Sci. 54, 427-445
44. Adams, J. M., and Cory, S. (1998) Science 281, 1322-1326
45. Perovic, S., Schroder, H. C., Pergande, G., Ushijima, H., and Muller, W. E. (1997) Exp. Neurol. 147, 518-524
46. Paradis, E., Douillard, H., Koutroumanis, M., Goodyer, C., and LeBlanc, A. (1996) J. Neurosci. 16, 7533-7539
47. Huang, D. C., Adams, J. M., and Cory, S. (1998) EMBO J. 17, 1029-1039
48. Cheng, E. H., Kirsch, D. G., Clem, R. J., Ravi, R., Kastan, M. B., Bedi, A., Ueno, K., and Hardwick, J. M. (1997) Science 278, 1966-1968
49. Kurschner, C., and Morgan, J. I. (1996) Brain Res. Mol. Brain Res. 37, 249-258
50. McCarthy, N. J., Whyte, M. K., Gilbert, C. S., and Evan, G. I. (1997) J. Cell Biol. 136, 215-227
51. Lavoie, J. N., Nguyen, M., Marcellus, R. C., Branton, P. E., and Shore, G. C. (1998) J. Cell Biol. 140, 637-645
52. Okuno, S., Shimizu, S., Ito, T., Nomura, M., Hamada, E., Tsujimoto, Y., and Matsuda, H. (1998) J. Biol. Chem. 273, 34272-34277
53. Saez-Valero, J., Angeretti, N., and Forloni, G. (2000) Neurosci. Lett. 293, 207-210
54. Greenlund, L. J., Deckwerth, T. L., and Johnson, E. M., Jr. (1995) Neuron 14, 303-315
55. Guentchev, M., Voigtlander, T., Haberler, C., Groschup, M. H., and Budka, H. (2000) Neurobiol. Dis. 7, 270-273
56. Milhavet, O., McMahon, H. E., Rachidi, W., Nishida, N., Katamine, S., Mange, A., Arlotto, M., Casanova, D., Riondel, J., Favier, A., and Lehmann, S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 13937-13942
57. Wong, B. S., Pan, T., Liu, T., Li, R., Petersen, R. B., Jones, I. M., Gambetti, P., Brown, D. R., and Sy, M. S. (2000) Biochem. Biophys. Res. Commun. 275, 249-252
58. Kowaltowski, A. J. (2000) Braz. J. Med. Biol. Res. 33, 241-250
59. Herms, J. W., Korte, S., Gall, S., Schneider, I., Dunker, S., and Kretzschmar, H. A. (2000) J. Neurochem. 75, 1487-1492
60. Kawahara, M., Kuroda, Y., Arispe, N., and Rojas, E. (2000) J. Biol. Chem. 275, 14077-14083
61. Thellung, S., Florio, T., Villa, V., Corsaro, A., Arena, S., Amico, C., Robello, M., Salmona, M., Forloni, G., Bugiani, O., Tagliavini, F., and Schettini, G. (2000) Neurobiol. Dis. 7, 299-309
62. Silei, V., Fabrizi, C., Venturini, G., Salmona, M., Bugiani, O., Tagliavini, F., and Lauro, G. M. (1999) Brain Res. 818, 168-170
63. Gupta, P. D., and Pushkala, K. (1999) Cytobios 99, 83-95
64. Andreyev, A., and Fiskum, G. (1999) Cell Death Differ. 6, 825-832
65. Behrens, M. M., Martinez, J. L., Moratilla, C., and Renart, J. (1995) Cell Growth Differ. 6, 1375-1380
66. Tombal, B., Weeraratna, A. T., Denmeade, S. R., and Isaacs, J. T. (2000) Prostate 43, 303-317
67. Sims, N. R., Finegan, J. M., Blass, J. P., Bowen, D. M., and Neary, D. (1987) Brain Res. 436, 30-38
68. Singer, T. P., Castagnoli, N., Jr., Ramsay, R. R., and Trevor, A. J. (1987) J. Neurochem. 49, 1-8
69. Choi, S. I., Ju, W. K., Choi, E. K., Kim, J., Lea, H. Z., Carp, R. I., Wisniewski, H. M., and Kim, Y. S. (1998) Acta Neuropathol. 96, 279-286
70. McHattie, S. J., Brown, D. R., and Bird, M. M. (1999) J. Neurocytol. 28, 149-159
71. Lin, M. C., Mirzabekov, T., and Kagan, B. L. (1997) J. Biol. Chem. 272, 44-47
72. Kawahara, M., and Kuroda, Y. (2000) Brain Res. Bull. 53, 389-397
73. Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., and Green, D. R. (1995) J. Exp. Med. 182, 1545-1556
74. McKenna, S. L., Carmody, R. J., and Cotter, T. G. (1999) Cell Engineering, Kluwer Academic Publishers, Dordrecht, The Netherlands
75. Kuwahara, C., Takeuchi, A. M., Nishimura, T., Haraguchi, K., Kubosaki, A., Matsumoto, Y., Saeki, K., Matsumoto, Y., Yokoyama, T., Itokara, S., and Onodera, T. (1999) Nature 400, 225-226