Human cytomegalovirus and immunopathology

Springer Seminars in Immunopathology

Volumn 24, Issue 2, 2002, Pages 169-185

  Sissons, J G P ^a   Carmichael, A J ^a   McKinney, N ^a   Sinclair, J H ^a   Wills, M R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN PRESENTATION; CYTOMEGALIC INCLUSION BODY DISEASE; CYTOMEGALOVIRUS; GRAFT REJECTION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; NATURAL KILLER CELL; ORGAN TRANSPLANTATION; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; REVIEW; VASCULAR DISEASE; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS PNEUMONIA; ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTERY OCCLUSION; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; BLOOD CELL; BONE MARROW TRANSPLANTATION; BREAST MILK; CELL ACTIVITY; CELLULAR IMMUNITY; CYTOMEGALOVIRUS INFECTION; DISEASE ASSOCIATION; DNA VIRUS; DOWN REGULATION; ENDOTHELIUM CELL; EPITHELIUM CELL; GLOMERULOPATHY; GUILLAIN BARRE SYNDROME; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN CYTOMEGALOVIRUS; IMMUNOMODULATION; IMMUNOPATHOLOGY; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT; MACROPHAGE; MOLECULAR MIMICRY; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; RETINITIS; SALIVATION; SEROPREVALENCE; SEXUAL TRANSMISSION; SPERM; T LYMPHOCYTE; URINE; UTERINE CERVIX CYTOLOGY; VIROLOGY; VIRUS CELL INTERACTION; VIRUS GENE; VIRUS GENOME; VIRUS PARTICLE; VIRUS PATHOGENESIS; VIRUS REACTIVATION; VIRUS REPLICATION; VIRUS TRANSMISSION;

ANTIGEN PRESENTATION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; GRAFT REJECTION; HUMANS; IMMUNE TOLERANCE; KILLER CELLS, NATURAL; ORGAN TRANSPLANTATION; PNEUMONIA, VIRAL; VASCULAR DISEASES; VIRUS ACTIVATION; VIRUS LATENCY;

ANTIVIRUS AGENT; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; EPITOPE; GLYCOPROTEIN B; IMMUNOGLOBULIN G ANTIBODY; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 10; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MICROSOMAL AMINOPEPTIDASE; T LYMPHOCYTE RECEPTOR; VIRUS DNA; VIRUS PROTEIN;

EID: 0036026869     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00281-002-0104-0     Document Type: Review

References (83)

1. Andrews DM, et al (2001) Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. Nat Immunol 2: 1077
2. Ang CW, et al (2000) Cross-reactive antibodies against GM2 and CMV-infected fibroblasts in Guillain-Barre syndrome. Neurology 54: 1453
3. Arase H, et al (2002) Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296: 1323
4. Barry SM, Johnson MA, Janossy G (2000) Cytopathology or immunopathology? The puzzle of cytomegalovirus pneumonitis revisited. Bone Marrow Transplant 26: 591
5. Becker BN, et al (1999) Peripheral vascular disease and renal transplant artery stenosis: A reappraisal of transplant renovascular disease. Clin Transplant 13: 349
6. Benedict CA, et al (1999) Cutting edge: A novel viral TNF receptor superfamily member in virulent strains of human cytomegalovirus. J Immunol 162: 6967
7. Bodaghi B, et al (1998) Chemokine sequestration by viral chemoreceptors as a novel viral escape strategy: Withdrawal of chemokines from the environment of cytomegalovirus-infected cells. J Exp Med 188: 855
8. Borchers AT, et al (1999) Role of cytomegalovirus infection in allograft rejection: A review of possible mechanisms. Transpl Immunol 7: 75
9. Brown MG, et al (2001) Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science 292: 934
10. Bruggeman CA (2000) Does cytomegalovirus play a role in atherosclerosis? Herpes 7: 51
11. Bukowski JF, et al (1985) Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivo. J Exp Med 161: 40
12. Cerwenka A, Lanier LL (2001) Natural killer cells, viruses and cancer. Nature Rev Immunol 1: 41
13. Cosman D, et al (2001) ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 14: 123
14. Craigen JL, Grundy JE (1996) Cytomegalovirus induced up-regulation of LFA-3 (CD58) and ICAM-1 (CD54) is a direct viral effect that is not prevented by ganciclovir or foscarnet treatment. Transplantation 62: 1102
15. Curtis HA, Singh T, Newkirk MM (1999) Recombinant cytomegalovirus glycoprotein gB (UL55) induces an autoantibody response to the U1-70 kDa small nuclear ribonucleoprotein. Eur J Immunol 29: 3643
16. Danesh J, Collins R, Peto R (1997) Chronic infections and coronary heart disease: Is there a link? Lancet 350: 430
17. Farrell HE, et al (1997) Inhibition of natural killer cells by a cytomegalovirus MHC class I homologue in vivo. Nature 386: 510
18. Fortunato EA, et al (2000) Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus. Trends Microbiol 8: 111
19. Gilbert MJ, et al (1996) Cytomegalovirus selectively blocks antigen processing and presentation of its immediate-early gene product. Nature 383: 720
20. Gillespie GM, et al (2000) Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors. J Virol 74: 8140
21. Grefte A, et al (1993) Circulating cytomegalovirus (CMV)-infected endothelial cells in patients with an active CMV infection. J Infect Dis 167: 270
22. Groh V, et al (2001) Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat Immunol 2: 255
23. Heise MT, Connick M, Virgin HWt (1998) Murine cytomegalovirus inhibits interferon gamma-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class II-associated genes. J Exp Med 187: 1037
24. Hengel H, et al (1995) Cytokines restore Mhc class-I complex-formation and control antigen presentation in human cytomegalovirus-infected cells. J Gen Virol 76: 2987
25. Hengel H, et al (2000) Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirus. J Virol 74: 7861
26. Hewitt EW, Gupta SS, Lehner PJ (2001) The human cytomegalovirus gene product US6 inhibits ATP binding by TAP. Embo J 20: 387
27. Hiemstra HS, et al (2001) Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase. Proc Natl Acad Sci USA 98: 3988
28. Hosenpud JD (1999) Coronary artery disease after heart transplantation and its relation to cytomegalovirus. Am Heart J 138: S469
29. Johnson DC, Hill AB (1998) Herpesvirus evasion of the immune system. Curr Top Microbiol Immunol 232: 149
30. Karavellas MP, et al (2001) Immune recovery vitritis and uveitis in AIDS: Clinical predictors, sequelae, and treatment outcomes. Retina 21: 1
31. Karavellas MP, et al (1999) Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of successful highly active antiretroviral therapy. J Infect Dis 179: 697
32. Kashyap R, et al (1999) The clinical significance of cytomegaloviral inclusions in the allograft kidney. Transplantation 67: 98
33. Khalili-Shirazi A, et al (1999) Antiganglioside antibodies in Guillain-Barre syndrome after a recent cytomegalovirus infection. J Neurol Neurosurg Psychiatry 66: 376
34. Koskinen PK, et al (1999) Cytomegalovirus infection and cardiac allograft vasculopathy. Transpl Infect Dis 1: 115
35. Kotenko SV, et al (2000) Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10). Proc Natl Acad Sci USA 97: 1695
36. Lautenschlager I, et al (1997) Persistent cytomegalovirus in liver allografts with chronic rejection. Hepatology 25: 190
37. Lautenschlager I, et al (1997) Effect of cytomegalovirus on an experimental model of chronic renal allograft rejection under triple-drug treatment in the rat. Transplantation 64: 391
38. Lemstrom KB, et al (1994) Effect of ganciclovir prophylaxis on cytomegalovirus-enhanced allograft arteriosclerosis. Transpl Int 7 [Suppl 1]: S383
39. Leong CC, et al (1998) Modulation of natural killer cell cytotoxicity in human cytomegalovirus infection: The role of endogenous class I major histocompatibility complex and a viral class I homolog. J Exp Med 187: 1681
40. Lunardi C, et al (2000) Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells. Nat Med 6: 1183
41. Melnick JL, et al (1994) Cytomegalovirus DNA in arterial walls of patients with atherosclerosis. J Med Virol 42: 170
42. Miller DM, et al (1998) Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway. J Exp Med 187: 675
43. Mocarski ES, Courcelle CT (2001) Cytomegaloviruses and their replication. In: Knipe DM, Howley PM (eds) Fields Virology. Lippincott Williams and Wilkins, Philadelphia, pp 2629-2674
44. Moller E, Soderberg-Naucler C, Sumitran-Karuppan S (1999) Role of alloimmunity in clinical transplantation. Rev Immunogenet 1: 309
45. Murphy PM (2001) Viral exploitation and subversion of the immune system through chemokine mimicry. Nat Immunol 2: 116
46. Neumann FJ, et al (2001) Previous cytomegalovirus infection and restenosis after coronary stent placement. Circulation 104: 1135
47. Orbaek Andersen H (1999) Heart allograft vascular disease: An obliterative vascular disease in transplanted hearts. Atherosclerosis 142: 243
48. Pass RF (2001) Cytomegalovirus. In: Knipe DM, Howley PM (eds) Fields Virology. Lippincott Williams and Wilkins, Philadelphia. pp 2675-2706
49. Pass RF, et al (1999) A subunit cytomegalovirus vaccine based on recombinant envelope glycoprotein B and a new adjuvant. J Infect Dis 180: 970
50. Penfold ME, et al (1999) Cytomegalovirus encodes a potent alpha chemokine. Proc Natl Acad Sci USA 96: 9839
51. Pleskoff O, et al (1997) Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry. Science 276: 1874
52. Podlech J, et al (2000) Murine model of interstitial cytomegalovirus pneumonia in syngeneic bone marrow transplantation: Persistence of protective pulmonary CD8 T cell infiltrates after clearance of acute infection. J Virol 74: 7496
53. Polic B, et al (1998) Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection. J Exp Med 188: 1047
54. Pouria S, et al (1998) CMV infection is associated with transplant renal artery stenosis. Q J Med 91: 185
55. Raftery MJ, et al (2001) Targeting the function of mature dendritic cells by human cytomegalovirus: A multilayered viral defense strategy. Immunity 15: 997
56. Reddehase MJ (2000) The immunogenicity of human and murine cytomegaloviruses. Curr Opin Immunol 12: 390
57. Reinhardt B, Minisini R, Mertens T (2002) Opinion article: Cytomegalovirus is a risk factor in atherogenesis. Herpes 9: 21
58. Rubin RH (2001) Cytomegalovirus in solid organ transplantation. Transpl Infect Dis 3 [Suppl 2]: 1
59. Saederup N, et al (2001) Murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is a determinant of dissemination that increases inflammation at initial sites of infection. J Virol 75: 9966
60. Scalzo AA, et al (1992) The effect of the Cmv-1 resistance gene, which is linked to the natural killer cell gene complex, is mediated by natural killer cells. J Immunol 149: 581
61. Sinclair J, Sissons P (1996) Latent and persistent infections of monocytes and macrophages. Intervirology 39: 293
62. Sinzger C, et al (1996) Tissue macrophages are infected by human cytomegalovirus in vivo. J Infect Dis 173: 240
63. Sinzger C, et al (1999) Modification of human cytomegalovirus tropism through propagation in vitro is associated with changes in the viral genome. J Gen Virol 80: 2867
64. Speir E, et al (1994) Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. Science 265: 391
65. Sutherland CL, Chalupny NJ, Cosman D (2001) The UL16-binding proteins, a novel family of MHC class I-related ligands for NKG2D, activate natural killer cell functions. Immunol Rev 181: 185
66. Tanaka K, et al (1999) Effects of human cytomegalovirus immediate-early proteins on p53-mediated apoptosis in coronary artery smooth muscle cells. Circulation 99: 1656
67. Taylor-Wiedeman J, et al (1993) Polymorphonuclear cells are not sites of persistence of human cytomegalovirus in healthy individuals. J Gen Virol 74: 265
68. Tomasec P, et al (2000) Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science 287: 1031
69. + T cells. Nat Med 5: 1039
70. Van den Berg AP, et al (1996) Cytomegalovirus infection does not increase the risk of vanishing bile duct syndrome after liver transplantation. Transpl Int 9 [Suppl 1]: S171
71. Van der Bij W, Speich R (2001) Management of cytomegalovirus infection and disease after solid-organ transplantation. Clin Infect Dis 33 [Suppl 1]: S32
72. Varani S, et al (2002) Autoantibody appearance in cytomegalovirus-infected liver transplant recipients: Correlation with antigenemia. J Med Virol 66: 56
73. Weekes MP, et al (1999) The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo. J Virol 73: 2099
74. Weill D (2001) Role of cytomegalovirus in cardiac allograft vasculopathy. Transpl Infect Dis 3 [Suppl 2]: 44
75. Whitcup SM (2000) Cytomegalovirus retinitis in the era of highly active antiretroviral therapy. Jama 283: 653
76. White KL, Slobedman B, Mocarski ES (2000) Human cytomegalovirus latency-associated protein pORF94 is dispensable for productive and latent infection. J Virol 74: 9333
77. Wiertz EJ, Mukherjee S, Ploegh HL (1997) Viruses use stealth technology to escape from the host immune system. Mol Med Today 3: 116
78. Wiertz EJ, et al (1996) Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature 384: 432
79. Wills MR, et al (1996) The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: Frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J Virol 70: 7569
80. + T cells comprise both naive and memory cells. J Immunol 162: 7080
81. Yilmaz S, et al (1996) Cytomegalovirus infection-enhanced chronic kidney allograft rejection is linked with intercellular adhesion molecule-1 expression. Kidney Int 50: 526
82. Yuki N (2001) Infectious origins of, and molecular mimicry in, Guillain-Barre and Fisher syndromes. Lancet Infect Dis 1: 29
83. Zhou YF, et al (1996) Association between prior cytomegalovirus infection and the risk of restenosis after coronary atherectomy. N Engl J Med 335: 624