Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of successful highly active antiretroviral therapy

Journal of Infectious Diseases

Volumn 179, Issue 3, 1999, Pages 697-700

  Karavellas, Marietta P ^a,b,c   Plummer, Daniel J ^a,b,c   Macdonald, J Christopher ^a,b,c   Torriani, Francesca J ^a,b,c   Shufelt, Chrisandra L ^a,b,c   Azen, Stanley P ^a,b,c   Freeman, William R ^a,b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CIDOFOVIR; INDINAVIR; LAMIVUDINE; NELFINAVIR; RITONAVIR; SAQUINAVIR; STAVUDINE; ZIDOVUDINE;

ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DISEASE SEVERITY; HUMAN; INCIDENCE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RETINITIS; RISK ASSESSMENT; VITREOUS DISEASE;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIVIRAL AGENTS; CALIFORNIA; COHORT STUDIES; CYTOMEGALOVIRUS RETINITIS; CYTOSINE; EYE DISEASES; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; INFLAMMATION; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; SYNDROME; TIME FACTORS; VISUAL ACUITY; VITREOUS BODY;

EID: 0033391432     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314639     Document Type: Article

References (15)

1. 1. Lederman M, Conici E, Landay A, et al. Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir; results of the AIDS Clinical Trial Group Protocol 315. J Infect Dis 1998;178:70-9.
2. 2. Autran B, Carcelain G, Li TS, et al. Positive effects of combined antiretroviral therapy CD4 T-cell homeostasis and function in advanced HIV disease. Science 1997;277:112-6.
3. 3. Palella FJ, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998;338:853-60.
4. + counts and prevalence of cytomegalovirus retinitis and human immunodeficiency virus related noninfectious retinal vasculopathy in patients with acquired immunodeficiency syndrome. Am J Ophthal 1993;115: 575-82.
5. 5. Jacobson MA, French M. Altered natural history of AIDS-related opportunistic infections in the era of potent combination antiretroviral therapy. AIDS 1998;12(suppl A):S157-63.
6. 6. Whitcup SM, Fortin E, Nussenblat RB, Polis MA, Muccioli C, Belfort R Jr. Therapeutic effect of combination antiretroviral therapy on cytomegalovirus retinitis. JAMA 1997;277:1519-20.
7. 7. Tural C, Romeu J, Sirera G, et al. Long-lasting remission of cytomegalovirus retinitis without maintenance therapy in human immunodeficiency virus infected patients. J Infect Dis 1998;177:1080-3.
8. 8. Macdonald JC, Torriani FJ, Morse LS, Karavellas MK, Reed JB, Freeman WR. Lack of reactivation of cytomegalovirus retinitis after stopping CMV maintenance therapy in AIDS patients with sustained elevations in CD4 T cells in response to highly active antiretroviral therapy. J Infect Dis 1998;177:1182-7
9. 9. Palestine AG, Rodrigues MM, Macher AM, et al. Ophthalmic involvement in acquired immunodeficiency syndrome. Ophthalmology 1984;91: 1092-9.
10. 10. Karavellas MP, Lowder CY, Macdonald JC, Avila CP, Freeman WR. Immune recovery vitritis associated with inactive CMV retinitis: a new syndrome. Arch Ophthalmol 1998;116:169-75.
11. 11. Zegans ME, Walton RC, Holland GN, O'Donnell JJ, Jacobson MA, Margolis TP. Transient vitreous inflammatory reactions associated with combination antiretroviral therapy in patients with AIDS and cytomegalovirus retinitis. Am J Ophthalmol 1998;125:292-300.
12. 12. Nussenblatt RB, Palestine AG, Chan CC, et al. Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology 1985;92:467-71.
13. 13. Studies of Ocular Complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. Foscarnet-ganciclovir cytomegalovirus retinitis trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Am J Ophthalmol 1997;124:141-57.
14. 14. Egbert PR, Pollard RB, Gallagher JG, Merigan TC. Cytomegalovirus retinitis in immunosuppressed hosts. Ann Intern Med 1980;93:664-70.
15. 15. Phillips P, Zala C, Rouleau D, Montaner JSG. Mycobacterial lymphadenitis: can highly active antiretroviral therapy unmask subclinical infection? [abstract] In: 4th Conference on Retroviruses and Opportunistic Infections: program and abstracts (Washington DC). Alexandria, VA: Infectious Diseases Society of America, 1996:129.