Opinion Article: Cytomegalovirus is a Risk Factor in Atherogenesis

Herpes

Volumn 9, Issue 1, 2002, Pages 21-23

  Reinhardt, Barbara ^a   Minisini, Rosalba ^a   Mertens, Thomas ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Atherogenesis atherosclerosis; Human cytomegalovirus infection

Indexed keywords

BETA CHEMOKINE; CHEMOKINE; GROWTH FACTOR; IMMEDIATE EARLY PROTEIN; IMMEDIATE EARLY PROTEIN 84; INTERCELLULAR ADHESION MOLECULE 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS DNA;

APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROSIS; CELL ADHESION; CELL MIGRATION; CELL TYPE; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS INFECTION; ENDOTHELIUM CELL; ENDOTHELIUM LESION; GENE EXPRESSION REGULATION; INFLAMMATORY CELL; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MONOCYTE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SMOOTH MUSCLE FIBER; VIRUS GENOME; VIRUS IDENTIFICATION; VIRUS LATENCY; ARTERIOSCLEROSIS; ARTICLE; BIOLOGICAL MODEL; CYTOMEGALIC INCLUSION BODY DISEASE; CYTOMEGALOVIRUS; GENETICS; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; PATHOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM; VIROLOGY;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

ANTIGENS, VIRAL; ARTERIOSCLEROSIS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; ENDOTHELIUM, VASCULAR; HUMANS; MODELS, BIOLOGICAL; RISK FACTORS;

EID: 0036548881     PISSN: 09697667     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (24)

1. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999;340:115-126.
2. Fabricant C, Fabricant J, Minick C, Litrenta M. Herpesvirus-induced atherosclerosis in chickens. Fed Proc 1983;42:2476-2479.
3. Lemstrom K, Koskinen P, Krogerus L, Daemen M, Bruggeman C, Hayry P. Cytomegalovirus antigen expression, endothelial cell proliferation, and intimal thickening in rat cardiac allografts after cytomegalovirus infection. Circulation 1995;92:2594-2604.
4. Lemstrom KB, Bruning JH, Bruggeman CA, Lautenschlager IT, Hayry PJ. Cytomegalovirus infection enhances smooth muscle cell proliferation and intimal thickening of rat aortic allografts. J Clin Invest 1993;92:549-558.
5. Kloover JS, Soots AP, Krogerus LA, Kauppinen HO, Loginov RJ, Holma KL et al. Rat cytomegalovirus infection in kidney allograft recipients is associated with increased expression of intracellular adhesion molecule-1 vascular adhesion molecule-1, and their ligands leukocyte function antigen-1 and very late antigen-4 in the graft. Transplantation 2000;69:2641-2647.
6. Burnett MS, Gaydos CA, Madico GE, Glad SM, Paigen B, Quinn TC et al. Atherosclerosis in apoE knockout mice infected with multiple pathogens. J Infect Dis 2001;183:226-231.
7. Adam E, Melnick JL, Probtsfield JL, Petrie BL, Burck J, Bailey KR et al. High levels of cytomegalovirus antibody in patients requiring vascular surgery for atherosclerosis. Lancet 1987;2:291-293.
8. Hendrix MG, Daemen M, Bruggeman CA. Cytomegalovirus nucleid acid distribution within the human vascular tree. Am J Pathol 1991;138:563-567.
9. Grattan MT, Moreno-Cabral CE, Starnes VA, Oyer PE, Stinson EB, Shumway NE. Cytomegalovirus infection is associated with cardiac allograft rejection and atherosclerosis. JAMA 1989;261:3561-3566.
10. Pouria S, State OI, Wong W, Hendry BM. CMV infection is associated with transplant renal artery stenosis. QJM 1998;3:185-189.
11. Zhou YF, Leon MB, Waclawiw MA, Popma JJ, Yu ZX, Finkel T et al. Association between prior cytomegalovirus infection and the risk of restenosis after coronary atherectomy. N Engl J Med 1996;335:624-630.
12. Waldman WJ, Knight DA. Cytokine-mediated induction of endothelial adhesion molecule and histocompatibility leukocyte antigen expression by cytomegalovirus-activated T cells. Am J Pathol 1996;148:105-119.
13. Zhu H, Cong J-P, Mamtora G, Gingeras T, Shenk T. Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proc Natl Acad Sci U S A 1998;95:14470-14475.
14. Guetta E, Guetta V, Shibutani T, Epstein SE. Monocytes harboring cytomegalovirus: interactions with endothelial cells, smooth muscle cells, and oxidized low-density lipoprotein. Possible mechanisms for activating virus delivered by monocytes to sites of vascular injury. Circ Res 1997;81:8-16.
15. Speir E, Modali R, Huang ES, Leon F, Shawl F, Finkel T et al. Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. Science 1994;265:391-394.
16. Fortunato EA, Spector DH. Regulation of human cytomegalovirus gene expression. Adv Virus Res 1999;54:61-127.
17. Zhou YF, Yu ZX, Wanishsawad C, Shou M, Epstein SE. The immediate early gene products of human cytomegalovirus increase vascular smooth muscle cell migration, proliferation, and expression of PDGF β-receptor. Biochem Biophys Res Commun 1999;256:606-613.
18. Streblow DN, Soderberg-Naucler C, Vieira J, Smith P, Wakabayashi E, Ruchti F et al. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration. Cell 1999;99:511-520.
19. Beisser PS, Laurent L, Virelizier JL, Michelson S. Human cytomegalovirus chemokine receptor gene US28 is transcribed in latently infected THP-1 monocytes. J Virol 2001;75:5949-5957.
20. Almeida GD, Porada CD, St Jeor S, Ascensao JL. Human cytomegalovirus alters interleukin-6 production by endothelial cells. Blood 1994;83:370-376.
21. Murayama T, Ohara Y, Obuchi M, Khabar KA, Higashi H, Mukaida N et al. Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1 and NF-kB-binding sites of the interleukin-8 gene. J Virol 1997;71:5692-5695.
22. % mice reveals a role for chemokines in the initiation of artherosclerosis. Nature 1998;394:894-897.
23. Knight DA, Waldman WJ, Sedmak DD. Cytomegalovirus-mediated modulation of adhesion molecule expression by human arterial and microvascular endothelial cells. Transplantation 1999;68:1814-1818.
24. Schaarschmidt P, Reinhardt B, Michel D, Vaida B, Mayr K, Lüske A et al. Altered expression of extracellular matrix in human-cytomegalovirus-infected cells and a human artery organ culture model to study its biological relevance. Intervirology 1999;42:357-364.