Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirus

Journal of Virology

Volumn 74, Issue 17, 2000, Pages 7861-7868

  Hengel, H ^a   Reusch, U ^a   Geginat, G ^a   Holtappels, R ^a   Ruppert, T ^a   Hellebrand, E ^a   Koszinowski, U H ^a  

^a ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANTIGEN PRESENTATION; ARTICLE; CELL DIVISION; CELL LINE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING;

ANIMALS; ANTIGEN PRESENTATION; BONE MARROW CELLS; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CYTOMEGALOVIRUS; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMEDIATE-EARLY PROTEINS; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; VIRAL ENVELOPE PROTEINS; VIRAL PROTEINS;

EID: 0033900029     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.17.7861-7868.2000     Document Type: Article

References (58)

1. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process
2. The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP
3. Control of cytomegalovirus in bone marrow transplantation chimeras lacking the prevailing antigen-presenting molecule in recipient tissues rests primarily on recipient-derived CD8 T cells
4. Dendritic cells and the control of immunity
5. Cytomegalovirus
6. Characterization of the murine cytomegalovirus early transcription unit e1 that is induced by immediate-early proteins
7. Cross-presentation: A general mechanism for CTL immunity and tolerance
8. Biphasic viremia and viral gene expression in leukocytes during acute cytomegalovirus infection of mice
9. Virus attenuation after depletion of the cytomegalovirus Fc receptor gene is not due to antibody control
10. Cytomegalovirus prevents antigen presentation by blocking the transport of peptide-loaded major histocompatibility complex class I molecules into the medial-Golgi compartment
11. Presentation of cytomegalovirus immediate-early antigens to cytolytic T lymphocytes is selectively blocked by viral genes expressed in the early phase
12. A novel mechanism for persistence of human cytomegalovirus in macrophages
13. Growth kinetics of human cytomegalovirus are altered in monocyte-derived macrophages
14. Mycobacterial growth inhibition by interferon-gamma-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis
15. IFN-γ is a prerequisite for optimal antigen processing of viral peptides in vivo
16. CMV remains latent in a common precursor of myeloid and dendritic cells
17. Replication of murine cytomegalovirus in differentiated macrophages as a determinant of viral pathogenesis
18. Generation, translocation, and presentation of MHC class I-restricted peptides
19. Murine cytomegalovirus inhibits interferon γ-induced antigen presentation to CD4 T cells by macrophages via regulation of expression of major histocompatibility complex class II-associated genes
20. Immune evasion by cytomegalovirus - survival strategies of a highly adapted opportunist
21. A viral ER resident glycoprotein inactivates the MHC encoded peptide transporter
22. Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape
23. Detection of murine cytomegalovirus immediate early 1 transcripts in the spleens of latently infected mice
24. Cytomegalovirus inhibits CD14 expression on human alveolar macrophages
25. Human cytomegalovirus productively infects primary differentiated macrophages
26. Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains
27. Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains
28. A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection
29. A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but transported to the cell surface
30. Human cytomegalovirus latent gene expression in granulocyte-macrophage progenitors in culture and in seropositive individuals
31. The immunoevasive function encoded by the mouse cytomegalovirus gene m152 protects the virus against T cell control in vivo
32. Fibroblasts as efficient antigen-presenting cells in lymphoid organs
33. Focal transcriptional activity of murine cytomegalovirus during latency in the lungs
34. Latency versus persistence or intermittent recurrences: Evidence for a latent state of murine cytomegalovirus in the lungs
35. The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation
36. Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host
37. Reconstitution of CD8 T cells is essential for the preventing of multiple-organ cytomegalovirus histopathology after bone marrow transplantation
38. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection
39. Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors
40. Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection
41. CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity
42. Interstitial murine cytomegalovirus pneumonia after irradiation: Characterization of cells that limit viral replication during established infection of the lungs
43. Murine cytomegalovirus infection downregulates MHC class II expression on macrophages by induction of interleukin-10
44. A cytomegalovirus glycoprotein reroutes MHC class I complexes to lysosomes for degradation
45. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones
46. Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
47. Fibroblasts, epithelial cells, endothelial cells and smooth muscle cells are major targets of human cytomegalovirus infection in lung and gastrointestinal tissues
48. Tissue macrophages are infected by human cytomegalovirus in vivo
49. Quantitative analysis of latent human cytomegalovirus
50. Interferon-γ and tumor necrosis factor-α specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines
51. Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors
52. Peripheral blood mononuclear phagocytes mediate dissemination of murine cytomegalovirus
53. Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells
54. Capture and processing of exogenous antigens for presentation on MHC molecules
55. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
56. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
57. Expression of a murine cytomegalovirus early-late protein in latently infected mice
58. A mouse cytomegalovirus glycoprotein retains MHC class I complexes in the ERGIC/cis-Golgi