Human virus-specific CD8+ CTL clones revert from CD45RO(high) to CD45RA(high) in vivo: CD45RA(high) CD8+ T cells comprise both naive and memory cells

Journal of Immunology

Volumn 162, Issue 12, 1999, Pages 7080-7087

  Wills, Mark R ^a   Carmichael, Andrew J ^a   Weekes, Michael P ^a   Mynard, Kim ^a   Okecha, Georgina ^a   Hicks, Ray ^a   Sissons, J G Patrick ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CD8 ANTIGEN;

ANTIGEN SPECIFICITY; ARTICLE; CYTOMEGALOVIRUS INFECTION; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; MEMORY CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD45; CARRIER STATE; CELL LINE; CLONE CELLS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; HUMANS; IMMUNOLOGIC MEMORY; LEUKOCYTES, MONONUCLEAR; LONGITUDINAL STUDIES; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOSPHOPROTEINS; STEM CELLS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; TIME FACTORS; VIRAL MATRIX PROTEINS;

EID: 0033564666     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Janeway, C. A. Jr. 1992. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation Annu. Rev. Immunol. 10:645.
2. Prince, H. E., J. York, and E. R. Jensen. 1992. Phenotypic comparison of the three populations of human lymphocytes defined by CD45RO and CD45RA expression. Cell. Immunol. 145:254.
3. Zola, H., L. Flego, P. J. Macardle, P. J. Donohoe, J. Ranford, and D. Roberton. 1992. The CD45RO (p180, UCHL1) marker: complexity of expression in peripheral blood. Cell. Immunol. 145:175.
4. + cells with different requirements for activation and differentiation. J. Immunol. 146:2088.
5. - T cells contain cells with high levels of lymphocyte function-associated antigen-1 expression a phenotype of primed T cells. J. Immunol. 150:429.
6. Merkenschlager, M., and P. C. Beverley. 1989. Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45RO (UCHL1). Int. Immunol 1:450.
7. Dutton, R. W., L. M. Bradley, and S. L. Swain. 1998. T cell memory. Annu. Rev. Immunol. 16:201.
8. Michie, C. A., A. McLean, C. Alcock, and P. C. Beverley. 1992. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360:264.
9. + T cells. Cell. Immunol. 139:176.
10. + T cells during the primary immune response to Epstein-Barr virus in vivo. J. Exp. Med. 187:1395.
11. Taylor Wiedeman, J., P. Sissons, and J. Sinclair. 1994. Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriers. J. Virol. 68:1597.
12. + bone marrow progenitors. J. Gen. Virol. 77:3099.
13. Borysiewicz, L. K., J. K. Hickling, S. Graham, J. Sinclair, M. P. Cranage, G. L. Smith, and J. G. Sissons. 1988. Human cytomegalovirus-specific cytotoxic T cells: relative frequency of stage-specific CTL recognizing the 72-kD immediate early protein and glycoprotein B expressed by recombinant vaccinia viruses J. Exp. Med. 168:919.
14. Reusser, P., S. R. Riddell, J. D. Meyers, and P. D. Greenberg. 1991. Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease. Blood 78:1373.
15. + virus-specific cytotoxic T lymphocytes. J. Med. Virol. 43:103.
16. Wills, M. R., A. J. Carmichael, K. Mynard, X. Jin, M. P. Weekes, B. Plachter, and J. G. Sissons. 1996. The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J. Virol. 70:7569.
17. Weekes, M. P., M. R. Wills, K. Mynard, A. J. Carmichael, and J. G. Sissons. 1999. The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo. J. Virol. 73:2099.
18. Altman, J. D., P. A. H. Moss, P. J. R. Goulder, D. H. Barouch, M. G. McHeyzer Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science 274:94.
19. Murali Krishna, K., J. D. Altman, M. Suresh, D. J. Sourdive, A. J. Zajac, J. D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177.
20. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.
21. Akbar, A. N., N. Borthwick, M. Salmon, W. Gombert, M. Bofill, N. Shamsadeen, D. Pilling, S. Pett, J. E. Grundy, and G. Janossy. 1993. The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections: the role of apoptosis in T cell memory. J. Exp. Med. 178:427.
22. L expression. Immunology 89:397.
23. Soderberg Naucler, C., K. N. Fish, and J. A. Nelson. 1997. Reactivation of latent human cytomegalovirus by allogeneic stimulation of blood cells from healthy donors. Cell 91:119.
24. Tanchot, C., F. A. Lemonnier, B. Perarnau, A. A. Freitas, and B. Rocha. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276:2057.
25. + memory T cells in virus-infected hosts. J. Exp. Med. 183:1367.
26. Lau, L. L., B. D. Jamieson, T. Somasundaram, and R. Ahmed. 1994. Cytotoxic T-cell memory without antigen. Nature 369:648.
27. Selin, L. K., K. Vergilis, R. M. Welsh, and S. R. Nahill. 1996. Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections. J. Exp. Med. 183:2489.
28. Tough, D. F., P. Borrow, and J. Sprent. 1996. Induction of bystander T cell proliferation by viruses and type I interferon in vivo. Science 272:1947.
29. McHeyzer Williams, M. G., and M. M. Davis. 1995. Antigen-specific development of primary and memory T cells in vivo. Science 268:106.
30. Maryanski, J. L., C. V. Jongeneel, P. Bucher, J. L. Casanova, and P. R. Walker. 1996. Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones. Immunity 4:47.
31. + T-cell memory, CD45R subsets and the persistence of antigen: a unifying concept. Immunol. Today 19:60.
32. bright T cell subsets and their relationship to memory and naive T cells. Eur. J. Immunol. 27:2383.