The UL16-binding proteins, a novel family of MHC class I-related ligands for NKG2D, activate natural killer cell functions

Immunological Reviews

Volumn 181, Issue , 2001, Pages 185-192

  Sutherland, Claire L ^a   Jan Chalupny, N ^a   Cosman, David ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL SURFACE RECEPTOR; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NATURAL KILLER CELL RECEPTOR NKG2D; PROTEIN UL16; UNCLASSIFIED DRUG; VIRUS PROTEIN;

CELL FUNCTION; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; CYTOTOXICITY; EFFECTOR CELL; ENZYME ACTIVATION; HUMAN; IMMUNE RESPONSE; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROBIAL IMMUNITY; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR IMMUNITY;

ANIMALS; CARRIER PROTEINS; CYTOMEGALOVIRUS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KILLER CELLS, NATURAL; LIGANDS; MEMBRANE PROTEINS; MICE; PROTEIN BINDING; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; VIRAL PROTEINS;

EID: 0034900287     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2001.1810115.x     Document Type: Review

References (50)

1. Biology of natural killer cells
2. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
3. Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: Implications for the innate immune response
4. Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-γ by natural killer cells in vitro
5. Natural killer cell activation and inhibition by receptors for MHC class I
6. NK cell receptors
7. Early signaling via inhibitory and activating NK receptors
8. In search of the 'missing self': MHC molecules and NK cell recognition
9. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16, and stimulate NK cytotoxicity through the NKG2D receptor
10. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA
11. Ligands for the murine NKG2D receptor: Expression by tumor cells and activation of NK cells and macrophages
12. Human cytomegalovirus escape from immune detection
13. The pathogenicity of cytomegalovirus
14. Cytomegalovirus
15. Severe herpesvirus infections in an adolescent without natural killer cells
16. Natural killer cells in antiviral defense: Function and regulation by innate cytokines
17. Cytomegalovirus evasion of natural killer cell responses
18. Mechanisms of viral interference with MHC class I antigen processing and presentation
19. Viral subversion of the immune system
20. The UL16 gene of human cytomegalovirus encodes a glycoprotein that is dispensable for growth in vitro
21. Emerging principles for the recognition of peptide antigens by MHC class I molecules
22. ULBP1,2,3, novel MHC class I-related molecules which bind to human cytomegalovirus glycoprotein UL16, activate NK cells
23. Isolation and characterization of NK cell or NK/T cell-specific cDNA clones
24. An activating immunoreceptor complex formed by NKG2D and DAP10
25. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium
26. Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB
27. Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells
28. Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: One of the early inducible tones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein
29. The molecular and functional characterization of a dominant minor H antigen, H60
30. Genomic structures and characterization of Rae 1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain
31. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
32. Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 Å
33. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells
34. KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties
35. Control of lyric function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: Identification of perforin and granzyme B mobilization by functional ERK2
36. JAKs and STATs: Biological implications
37. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells
38. Association of DAP12 with activating CD94/NKG2C NK cell receptors
39. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
40. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis
41. Molecular cloning of NKp46: A novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity
42. Ly49D and Ly49H associate with mouse DAP12 and form activating receptors
43. DAP10 and DAP12 form distinct but functionally cooperative receptor complexes in natural killer cells
44. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not Th2 cytokines
45. - cytotoxic effector clones
46. - T lymphocytes: Antigenic and functional properties
47. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif
48. Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling
49. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells
50. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL