Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: Model for spindle checkpoint regulation

Molecular and Cellular Biology

Volumn 21, Issue 15, 2001, Pages 5190-5199

  Zhang, Y ^a   Lees, E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CELL CYCLE PROTEIN 20; CELL PROTEIN; MUTANT PROTEIN; PROTEIN MAD2; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANAPHASE; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; MODEL; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANAPHASE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CELL NUCLEUS; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FUNGAL PROTEINS; HUMANS; MICROSCOPY, FLUORESCENCE; MICROTUBULES; MITOSIS; MOLECULAR SEQUENCE DATA; MUTATION; NOCODAZOLE; NUCLEAR PROTEINS; PEPTIDES; PHENOTYPE; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

MAMMALIA;

EID: 0034952728     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.15.5190-5199.2001     Document Type: Article

References (41)

1. Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage
2. The spindle checkpoint
3. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
4. The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins
5. Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
6. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
7. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
8. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p
9. Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome
10. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae
11. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
12. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
13. A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast
14. Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2
15. Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption
16. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
17. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
18. Budding yeast Cdc20: A target of the spindle checkpoint
19. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
20. Fission yeast Slp1: An effector of the Mad2-dependent spindle
21. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
22. Feedback control of mitosis in budding yeast
23. Identification of a human mitotic checkpoint gene: hsMAD2
24. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20
25. Splitting the chromosome: Cutting the ties that bind sister chromatids
26. How cells get the right chromosomes
27. The spindle assembly checkpoint
28. Yeast Hct1 is a regulator of Clb2 cyclin proteolysis
29. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
30. The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
31. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis
32. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
33. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
34. Proteolytic ratchets that control progression through mitosis
35. Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
36. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
37. Mad2 transiently associates with an APC/p55Cdc complex during mitosis
38. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint
39. P55cdc/Hcdc20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase
40. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
41. p21Waf1/Cip1 acts in synergy with bcl-2 to confer multidrug resistance in a camptothecin-selected human lung-cancer cell line