Activation of peroxisome proliferator-activated receptor γ does not inhibit IL-6 or TNF-α responses of macrophages to lipopolysaccharide in vitro or in vivo

Journal of Immunology

Volumn 164, Issue 2, 2000, Pages 1046-1054

  Thieringer, Rolf ^a   Fenyk Melody, Judy E ^a   Le Grand, Cheryl B ^a   Shelton, Beverly A ^a   Detmers, Patricia A ^a   Somers, Elizabeth P ^a   Carbin, Linda ^a   Moller, David E ^a   Wright, Samuel D ^a   Berger, Joel ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; DELTA12 PROSTAGLANDIN J2; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENDOTOXEMIA; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY;

EID: 0034650330     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.2.1046     Document Type: Article

References (44)

1. Schoonjans, K., G. Martin, B. Staels, and J. Auwerx. 1997. Peroxisome proliferator-activated receptors, orphans with ligands and functions. Curr. Opin. Lipidol. 8:159.
2. Mangelsdorf, D. J., C. Thummel, M. Beato, P. Herrlich, G. Schutz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, et al. 1995. The nuclear receptor superfamily: the second decade. Cell 83:835.
3. Lemberger, T., B. Desvergne, and W. Wahli. 1996. Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu. Rev. Cell. Dev. Biol. 12:335.
4. Tontonoz, P., E. Hu, R. A. Graves, A. I. Budavari, and B. M. Spiegelman. 1994. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8:1224.
5. Elbrecht, A., Y. Chen, C. A. Cullinan, N. Hayes, M. Leibowitz, D. E. Moller, and J. Berger. 1996. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2. Biochem. Biophys. Res. Commun. 224:431.
6. Zhu, Y., C. Qi, J. R. Korenberg, X. N. Chen, D. Noya, M. S. Rao, and J. K. Reddy. 1995. Structural organization of mouse peroxisome proliferator-activated receptor γ (mPPARγ) gene: alternative promoter use and different splicing yield two mPPARy isoforms. Proc. Natl. Acad. Sci. USA 92:7921.
7. Tontonoz, P., E. Hu, and B. M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid- activated transcription factor. Cell 79:1147.
8. Brun, R. P., P. Tontonoz, B. M. Forman, R. Ellis, J. Chen, R. M. Evans, and B. M. Spiegelman. 1996. Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev. 10:974.
9. Lehmann, J. M., L. B. Moore, T. A. Smith-Oliver, W. O. Wilkison, T. M. Willson, and S. A. Kliewer. 1995. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270:12953.
10. Kliewer, S. A., J. M. Lenhard, T. M. Willson, I. Patel, D. C. Morris, and J. M. Lehmann. 1995. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 83:813.
11. 12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803.
12. Berger, J., M. D. Leibowitz, T. W. Doebber, A. Elbrecht, B. Zhang, G. Zhou, C. Biswas, C. A. Cullinan, N. S. Hayes, Y. Li, et al. 1999. Novel PPARγ and PPARδ ligands produce distinct biological effects. J. Biol. Chem. 274:6718.
13. Berger, J., P. Bailey, C. Biswas, C. A. Cullinan, T. W. Doebber, N. S. Hayes, R. Saperstein, R. G. Smith, and M. D. Leibowitz. 1996. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-γ: binding and activation correlate with antidiabetic actions in dh/db mice. Endocrinology 137:4189.
14. Chinetti, G., S. Griglio, M. Antonucci, I. P. Torra, P. Delerive, Z. Majd, J. C. Fruchart, J. Chapman, J. Najib, and B. Staels. 1998. Activation of proliferator-activated receptors α and γ induces apoptosis of human monocyte-derived macrophages. J. Biol. Chem. 273:25573.
15. Kliewer, S. A., B. M. Forman, B. Blumberg, E. S. Ong, U. Borgmeyer, D. J. Mangelsdorf, K. Umesono, and R. M. Evans. 1994. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. USA 91:7355.
16. Schoonjans, K., B. Staels, and J. Auwerx. 1996. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res. 37:907.
17. Issemann, I., and S. Green. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645.
18. Dreyer, C., G. Krey, H. Keller, F. Givel, G. Helftenbein, and W. Wahli. 1992. Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68:879.
19. Forman, B. M., J. Chen, and R. M. Evans. 1997. Hypolipidemic drugs, polyun-saturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc. Natl. Acad. Sci. USA 94:4312.
20. Kliewer, S. A., S. S. Sundseth, S. A. Jones, P. J. Brown, G. B. Wisely, C. S. Koble, P. Devchand, W. Wahli, T. M. Willson, J. M. Lenhard, et al. 1997. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc. Natl. Acad. Sci. USA 94:4318.
21. Jones, P. S., R. Savory, P. Barratl, A. R. Bell, T. J. Gray, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and D. R. Bell. 1995. Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes. Eur. J. Biochem. 233:219.
22. Xing, G., L. Zhang, T. Heynen, T. Yoshikawa, M. Smith, S. Weiss, and S. Detera-Wadleigh. 1995. Rat PPARδ contains a CGG triplet repeat and is prominently expressed in the thalamic nuclei. Biochem. Biophys. Res. Commun. 217: 1015.
23. Jiang, C., A. T. Ting, and B. Seed. 1998. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 391:82.
24. Ricote, M., A. C. Li, T. M. Willson, C. J. Kelly, and C. K. Glass. 1998. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391:79.
25. Manthey, C. L., P. Y. Perera, B. E. Henricson, T. A. Hamilton, N. Qureshi, and S. N. Vogel. 1994. Endotoxin-induced early gene expression in C3H/HeJ (LPSd) macrophages. J. Immunol. 153:2653.
26. Weiner, M. S., C. Bianco, and V. Nussenzweig. 1973. Enhanced binding of neuraminidase-treated sheep erythrocytes to human T lymphocytes. Blood 42: 939.
27. van der Meer, J. W., D. Bulterman, T. L. van Zwet, I. Elzenga-Claasen, and R. van Furth. 1978. Culture of mononuclear phagocytes on a Teflon surface to prevent adherence. J. Exp. Med. 147:271.
28. + receptor-mediated phagocytosis in cultured human monocytes. J. Exp. Med. 156:1149.
29. Marx, N., G. Sukhova, C. Murphy, P. Libby, and J. Plutzky. 1998. Macrophages in human atheroma contain PPARγ: differentiation-dependent peroxisomal proliferator-activated receptor γ (PPARγ) expression and reduction of MMP-9 activity through PPARγ activation in mononuclear phagocytes in vitro. Am. J. Pathol. 153:17.
30. Raschke, W. C., S. Baird, P. Ralph, and I. Nakoinz. 1978. Functional macrophage cell lines transformed by Abelson leukemia virus. Cell 15:261.
31. Faggioni, R., G. Fantuzzi, C. Gabay, A. Moser, C. A. Dinarello, K. R. Feingold, and C. Grunfeld. 1999. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am. J. Physiol. 276:R136.
32. Beutler, B., I. W. Milsark, and A. C. Cerami. 1985. Passive Immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 29:869 .
33. Dinarello, C. A. 1996. Cytokines as mediators in the pathogenesis of septic shock. Curr. Top. Microbiol. Immunol. 216:133.
34. Bone, R. C. 1994. Sepsis and its complications: the clinical problem. Crit. Care Med. 22:S8.
35. Berliner, J. A., M. Navab, A. M. Fogelman, J. S. Frank, L. L. Demer, P. A. Edwards, A. D. Watson, and A. J. Lusis. 1995. Atherosclerosis: basic mechanisms: oxidation, inflammation, and genetics. Circulation 91:2488.
36. Ross, R. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362:801.
37. Ricote, M., J. Huang, L. Fajas, A. Li, J. Welch, J. Najib, J. L. Witztum, J. Auwerx, W. Palinski, and C. K. Glass. 1998. Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc. Natl. Acad. Sci. USA 95:7614.
38. Yu, K., W. Bayona, C. B. Kallen, H. P. Harding, C. P. Ravera, G. McMahon, M. Brown, and M. A. Lazar. 1995. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J. Biol. Chem. 270:23975.
39. 2-integrin-dependent oxidative burst: involvement of a mechanism distinct from PPARγ ligation. J. Immunol. 163:6187.
40. Hill, M. R., S. Clarke, K. Rodgers, B. Thornhill, J. M. Peters, F. J. Gonzalez, and J. M. Gimble. 1999. Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia. Infect. Immun. 67:3488.
41. Katschinski, T., C. Galanos, A. Coumbos, and M. A. Freudenberg. 1992. γ Interferon mediates Propionibacterium acnes-induced hypersensitivity to lipopolysaccharide in mice. Infect. Immun. 60:1994.
42. Vogel, S. N., R. N. Moore, J. D. Sipe, and D. L. Rosenstreich. 1980. BCG-induced enhancement of endotoxin sensitivity in C3H/HeJ mice. I. In vivo studies. J. Immunol. 124:2004.
43. Gupta, S., A. M. Pablo, X. Jiang, N. Wang, A. R. Tall, and C. Schindler. 1997. IFN-γ potentiates atherosclerosis in ApoE knock-out mice. J. Clin. Invest. 99: 2752.
44. Shiomi, M., T. Ito, T. Tsukada, Y. Tsujita, and H. Horikoshi. 1999. Combination treatment with troglitazone, an insulin action enhancer, and pravastatin, an inhibitor of HMG-CoA reductase, shows a synergistic effect on atherosclerosis of WHHL rabbits. Atherosclerosis 142:345.