The expression of adhesion molecules on endothelial cells is inhibited by troglitazone through its antioxidant activity

Cell Adhesion and Communication

Volumn 7, Issue 3, 1999, Pages 223-231

  Cominacini, L ^a   Garbin, U ^a   Fratta Pasini, A ^a   Davoli, A ^a   Campagnola, M ^a   Rigoni, A ^a   Tosetti, L ^a   Lo Cascio, V ^a  

^a UNIVERSITY HOSPITAL OF VERONA   (Italy)

Author keywords

Adhesion molecules; Antioxidants; Oxidized LDL; Transcription factor NF B; Transcription factor PPAR ; Troglitazone; Tumor necrosis factor

Indexed keywords

ANTIOXIDANT; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FREE RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; ORAL ANTIDIABETIC AGENT; OXIDIZED LOW DENSITY LIPOPROTEIN; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN;

EID: 0032785335     PISSN: 10615385     EISSN: None     Source Type: Journal    
DOI: 10.3109/15419069909010804     Document Type: Article

References (40)

1. I. Joris et al. (1983) "Studies on the pathogenesis of atherosclerosis I. Adhesion and migration of mononuclear cells in the aorta of hypercholesterolemic rats". Am. J. Path. 113, 341-358.
2. T. Carlos et al. (1991) "Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1". Blood 77, 2266-2271.
3. C. Steiner (1985) "Atherosclerosis, the major complication of diabetes". Adv.Exp. Med. Biol. 189, 277-297.
4. J.R. Jeng et al. (1993) "Oxidized low-density lipoprotein enhances monocyte-endothelial cell binding against shear-stress-induced detachment." Biochim. Biophys. Acta 1178, 221-227.
5. B.V. Khan et al. (1995) "Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells". J. Clin. Invest. 95, 1262-1270.
6. L. Cominacini et al. (1997) "Antioxidants inhibit the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 induced by oxidized LDL on human umbilical vein endothelial cells". Free Rad. Biol. Med. 22, 117-127.
7. E.R. Lampeter et al. (1992) "Elevated levels of circulating adhesion molecules in IDDM patients and in subjects at risk for IDDM". Diabetes 41, 1668-1671.
8. M. Steiner et al. (1994) "Increased levels of soluble adhesion molecules in Type 2 (non-insulin dependent) diabetes mellitus are independent of glycaemic control". Thromb. Haemostasis 72, 979-984.
9. L. Cominacini et al. (1995) "Elevated levels of soluble E-selectin in patients with IDDM and NIDDM: relation to metabolic control". Diabetologia 38, 1122-1124.
10. L. Cominacini et al. (1997) "E-Selectin plasma concentration is influenced by glycaemic control in NIDDM patients: possible role of oxidative stress". Diabetologia 40, 584-589.
11. A.R. Saltiel and J.M. Olefsky (1996) "Thiazolidinediones in the treatment of insulin resistance and type II diabetes". Diabetes 45, 1661-1669.
12. S. Kumar et al. (1996) "For the Troglitazone study group: Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients". Diabetologia 39, 701-709.
13. J.M. Lehman et al. (1995) "An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ". J. Biol. Chem. 270, 12953-12956.
14. B.M. Forman et al. (1995) "15-deoxy-d12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ". Cell 83, 803-812.
15. T. Yoshioka et al. (1989) "Studies on hindered phenols and analogues. I. Hypolipidemic and hypoglycemic agents with ability to inhibit lipid peroxidation". J. Med. Chem. 32, 421-427.
16. L. Cominacini et al. (1997) "Effects of troglitazone on in vivo oxidation of LDL and HDL induced by copper ions and endothelial cells". Diabetologia 40, 165-172.
17. L. Cominacini et al. (1997) "Troglitazone increases the resistance of LDL to oxidation in healthy volunteers". Diabetologia 40, 1211-1218.
18. L. Cominacini et al. (1998) "Troglitazone reduces LDL oxidation and lowers plasma E-selectin concentration in NIDDM patients". Diabetes 47, 130-133.
19. A.S. Neish et al. (1992) "Funtional analysis of the human vascular cell adhesion molecule-1 promoter". J. Exp. Med. 176, 1583-1593.
20. M.F. Iademarco et al. (1992) "Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1)". J. Biol. Chem. 267, 16323-16329.
21. R. Schreck et al. (1991) "Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-1". EMBO. J. 10, 2247-2258.
22. R.J. Havel et al. (1995) "The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum". J. Clin. Invest. 34, 1345-1353.
23. U. Landegren (1984) "Measurement of cell numbers by means of the endogenous enzyme hexosaminidase: application to detection of lymphokines and cell surface antigens". J. Immunol. Methods 67, 379-385.
24. L. Cominacini et al. (1991) "A simple test for predisposition of LDL oxidation based on the fluorescence development during copper-catalyzed oxidative modification". J. Lipid Res. 32, 349-358.
25. L. Cominacini et al. (1996) "Mechanisms involved in the in vitro modification of low density lipoprotein by human umbilical vein endothelial cells and copper ions". J. Lipid Med. 13, 19-33.
26. P.K. Smith et al. (1985) "Measurement of protein using bicinchoninic acid". Anal. Biochem. 105, 293-299.
27. J.D. Dignam et al. (1983) "Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei". Nucleic Acids Res. 11, 1475-1489.
28. C.K. Sen and L. Packer (1996) "Antioxidant and redox regulation of gene transcription". FASEB. J. 10, 709-720.
29. T. Collins (1993) "Endothelial nuclear factor-kB and the initiation of the atherosclerotic lesion". Lab. Invest. 68, 499-508.
30. A. R. Saltiel and H. Horikoshi (1995) "Thiazolidinediones are novel insulin-sensitizing agents". Current Opinion in Endocrinology and Diabetes 2, 341-347.
31. I. Inoue et al. (1997) "Troglitazone has a scavenging effect on reactive oxygen species". Biochem. Biophys. Res. Commun. 235, 113-116.
32. P. Peraldi et al. (1997) "Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin signaling". J. Clin. Invest. 100, 1863-1869.
33. C. Weber et al. (1994) "Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals". Arterioscler. Thromb. 14, 1665-1673.
34. P.S. Tsao et al. (1996) "Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1". Circulation 94, 1682-1689.
35. T. Matsubara and M. Ziff (1986) "Increased Superoxide anion release in response to cytokines". J. Immunol. 137, 3295-3298.
36. L.S. Terada et al. (1991) "Generation of Superoxide anion by brain endothelial cell xanthine oxidase". J. Cell Physiol 148, 191-196.
37. K. A. Pritchard et al. (1990) "Atherogenic concentrations of low-density lipoprotein enhance endothelial cell generation of epoxyeicosatetrainoic acid products". Am. J. Pathol. 136, 1383-1391.
38. N. Marui et al (1993) "Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidants-sensitive mechanism in human vascular endothelial cells". J. Clin. Invest. 92, 1866-1874.
39. A. Bauskin et al. (1991) "Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum". Cell 66, 685-696.
40. T. Henkel et al. (1993) "Rapid proteolysis of IkB-alpha is necessary for activation of transcription factor NF-kB". Nature 365, 182-185.