The Chk1-Cdc25C regulation is involved in sensitizing A253 cells to a novel topoisomerase I inhibitor BNP1350 by bax gene transfer

Oncogene

Volumn 20, Issue 38, 2001, Pages 5249-5257

  Yin, Ming Biao ^a   Hapke, Gunnar ^a   Guo, Bin ^a   Azrak, Rami G ^a   Frank, Cheryl ^a   Rustum, Youcef M ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Bax; BNP1350; Cdc2; Cdc25C; Chk1; Cyclin B

Indexed keywords

CHECKPOINT KINASE 1; DNA FRAGMENT; DNA TOPOISOMERASE INHIBITOR; KARENITECIN; PROTEIN 14 3 3; PROTEIN BAX; PROTEIN PARP; PROTEIN TYROSINE PHOSPHATASE; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL GROWTH; CONTROLLED STUDY; DRUG RESPONSE; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME REGULATION; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL LINE; CYCLIN B; DNA FRAGMENTATION; DNA TOPOISOMERASES, TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; G2 PHASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE TRANSFER TECHNIQUES; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035974820     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1204686     Document Type: Article

References (52)