Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin in vitro and in vivo

International Journal of Cancer

Volumn 82, Issue 6, 1999, Pages 860-867

  Sugimoto, Chizuru ^a   Fujieda, Shigeharu ^a   Seki, Mizue ^a   Sunaga, Hiroshi ^a   Fan, Guo Kang ^a   Tsuzuki, Hideaki ^a   Borner, Christoph ^b   Saito, Hitoshi ^a   Matsukawa, Shigeru ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG SENSITIVITY; GENE EXPRESSION; GENE GUN; GENE TRANSFER; GENETIC TRANSFECTION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, SQUAMOUS CELL; CISPLATIN; DRUG RESISTANCE, NEOPLASM; GENE TRANSFER TECHNIQUES; GENES, REPORTER; HUMANS; MAXILLARY NEOPLASMS; MICE; MICE, INBRED C3H; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032838498     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990909)82:6<860::AID-IJC15>3.0.CO;2-6     Document Type: Article

References (20)

1. BARGOU, R.C., WAGENER, C., BOMMERT, K., MAPARA, M.Y., DANIEL, P.T., ARNOLD, W., DIETEL, M., GUSKI, H., FELLER, A., ROYER, H.D. AND DÖRKEN, B. Overexpression of the death-promoting gene bax-α which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J. clin. Invest., 97, 2651-2659 (1996).
2. BORNER, C., Diminished cell proliferation associated with the death-protective activity of Bcl-2. J. biol. Chem., 271, 12695-12698 (1996).
3. CHENG, L., ZIEGELHOFFER, P.R. AND YANG, N.-S. In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc. nat. Acad. Sci. (Wash.), 90, 4455-4459 (1993).
4. JANSEN, B., SCHLAGBAUER-WADL, H., BROWN, B.D., BRAYAN, R.N., ELSAS, A., MÜLLER, M., WOLFF, K., EICHLER, H.-G. and PEHAMBERGER, H., bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nature (Med.). 4, 232-234 (1998).
5. KAMESAKI, S., KAMESAKI, H., JORGENSEN, T.J., TANIZAWA. A., POMMIER, Y. and COSSMAN, J., bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase 2-induced DNA strand breaks and their repair. Cancer Res., 53, 4251-4256 (1993).
6. KRAJEWSKI, S., BLOMQVIST, C., FRANSSILA, K., KRAJEWSKA, M., WASENIUS, V.-M., NISKANEN, E., NORDLING, S. AND REED, J.C. Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. Cancer Res., 55, 4471-4478 (1995).
7. LU, C. AND TANIGAWA, N. Spontaneous apoptosis is inversely related to intratumoral microvessel density in gastric carcinoma. Cancer Res., 57, 221-224 (1997).
8. MATSUMOTO, N., SAITO, H., MIYOSHI, N., NAKANISHI, K. AND FUKUDA, M. Combination effect of hyperthermia and photodynamic therapy on carcinoma. Arch. Otolaryngol. Head Neck Surg., 116, 824-829 (1990).
9. NICOLETTI, I., MIGLIORATI, G., PAGLIACCI, M.C., GRIGNANI, F. and RICCARDI, C., A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods., 139, 271-279 (1991).
10. O'DWYER, P.J., MOYER, J.D., SUFFNESS, M., HARRISON, S.D., JR., CYSYK, R., HAMILTON, T.C. and PLOWMAN, J., Antitumor activity and biochemical effects of aphidicolin glycinate (NSC 303812) alone and in combination with cisplatin in vivo. Cancer Res., 54, 724-729 (1994).
11. OHTSUBO, T., SAITO, H., TANAKA, N., MATSUMOTO, H., SUGIMOTO, C., SAITO, T., HAYASHI, S. and KANO, E., Enhancement of cisplatin sensitivity and platinum uptake by 40°C hypertherrnia in resistant cells. Cancer Lett., 119, 47-52 (1997).
12. OLTVAI, Z.N., MILLIMAN, C.L. and KORSMEYER, S.J., Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell, 74, 609-619 (1993).
13. SAKAKURA, C. AND 14 OTHERS, Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis. Int. J. Cancer, 67, 101-105 (1996).
14. SEDLAK, T.W., OLTVAI, Z.N., YANG, E., WANG, K., BOISE, L.H., THOMPSON, C.B. and KORSMEYER, S.J., Multiple bcl-2 family members demonstrate selective dimerizations with bax. Proc. nat. Acad. Sci. (Wash.), 92, 7834-7838 (1995).
15. SUGIMOTO, C., MATSUKAWA, S., FUJIEDA, S., NODA, I., TANAKA, N., TSUZUKI, H. and SAITO, H., Involvement of intracellular glutathione in induction of apoptosis by cisplatin in a human pharyngeal carcinoma cell line. Anticancer Res., 16, 675-680 (1996).
16. TSUJIMOTO, Y. and CROCE, C.M., Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc. nat. Acad. Sci. (Wash.), 83, 5214-5218 (1986).
17. TSUZUKI, H., FUJIEDA, S., SUNAGA, H., NODA, I. AND SAITO, H. Expression of granulocyte colony-stimulating factor receptor correlates with prognosis in oral and mesopharyngeal carcinoma. Cancer Res., 58, 794-800 (1998).
18. WAGENER. C., BARGOU, R.C., DANIEL, P.T., BOMMERT, K., MAPARA, M.Y., ROYER, H.D. AND DÖRKEN, B. Induction of the death-promoting gene bax-α sensitizes cultured breast-cancer cells to drug-induced apoptosis. Int. J. Cancer, 67, 138-141 (1996).
19. YANG, N.-S. AND SUN, W.H. Gene gun and other non-viral approaches for cancer gene therapy. Nature (Med.), 1, 481-483 (1995).
20. YIN, C., KNUDSON, C.M., KORSMEYER, S.J., AND DYKE, T.V. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature (Lond.), 385, 637-640 (1997).