메뉴 건너뛰기




Volumn 16, Issue 15, 1997, Pages 4628-4638

The anti-apoptosis function of: Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

Author keywords

Apoptosis; Bcl 2; Bcl w; Bcl x(L); Cell cycle control

Indexed keywords

CELL PROTEIN; CYTOKINE; MUTANT PROTEIN; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TYROSINE; UNCLASSIFIED DRUG;

EID: 0030794452     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.15.4628     Document Type: Article
Times cited : (309)

References (86)
  • 3
    • 15844397398 scopus 로고    scopus 로고
    • Diminished cell proliferation associated with the death-protective activity of Bcl-2
    • Borner, C. (1996) Diminished cell proliferation associated with the death-protective activity of Bcl-2. J. Biol. Chem., 271, 12695-12698.
    • (1996) J. Biol. Chem. , vol.271 , pp. 12695-12698
    • Borner, C.1
  • 4
    • 0028167978 scopus 로고
    • The protein bcl-2α does not require membrane attachment, but two conserved domains to suppress apoptosis
    • Borner, C., Martinou, I., Mattmann, C., Irmler, M. Schaerer, E., Martinou, J.-C. and Tschopp, J. (1994) The protein bcl-2α does not require membrane attachment, but two conserved domains to suppress apoptosis. J. Cell Biol., 126, 1059-1068.
    • (1994) J. Cell Biol. , vol.126 , pp. 1059-1068
    • Borner, C.1    Martinou, I.2    Mattmann, C.3    Irmler, M.4    Schaerer, E.5    Martinou, J.-C.6    Tschopp, J.7
  • 6
    • 0028812606 scopus 로고
    • Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins
    • Boyd, J.M. et al. (1995) Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene, 11, 1921-1928.
    • (1995) Oncogene , vol.11 , pp. 1921-1928
    • Boyd, J.M.1
  • 7
    • 0030449990 scopus 로고    scopus 로고
    • Baxα perturbs T cell development and affects cell cycle entry of T cells
    • Brady, H.J.M., Gil-Gómez, G., Kirberg, J. and Berns, A.J.M. (1996) Baxα perturbs T cell development and affects cell cycle entry of T cells. EMBO J., 15, 6991-7001.
    • (1996) EMBO J. , vol.15 , pp. 6991-7001
    • Brady, H.J.M.1    Gil-Gómez, G.2    Kirberg, J.3    Berns, A.J.M.4
  • 9
    • 0031034997 scopus 로고    scopus 로고
    • Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death
    • Chinnaiyan, A.M., O'Rourke, K., Lane, B.R. and Dixit, V.M. (1997) Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science, 275, 1122-1126.
    • (1997) Science , vol.275 , pp. 1122-1126
    • Chinnaiyan, A.M.1    O'Rourke, K.2    Lane, B.R.3    Dixit, V.M.4
  • 10
    • 0028059445 scopus 로고
    • Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells
    • Chiou, S.-K., Tseng, C.-C., Rao, L. and White, E. (1994) Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells. J. Virol., 68, 6553-6566.
    • (1994) J. Virol. , vol.68 , pp. 6553-6566
    • Chiou, S.-K.1    Tseng, C.-C.2    Rao, L.3    White, E.4
  • 13
    • 0025349434 scopus 로고
    • The bcl-2 gene, follicular lymphoma, and Hodgkin's disease
    • Cleary, M. and Rosenberg, S.A. (1990) The bcl-2 gene, follicular lymphoma, and Hodgkin's disease. J. Natl Cancer Inst., 82, 808-809.
    • (1990) J. Natl Cancer Inst. , vol.82 , pp. 808-809
    • Cleary, M.1    Rosenberg, S.A.2
  • 14
    • 0028915454 scopus 로고
    • Regulation of lymphocyte survival by the BCL-2 gene family
    • Cory, S. (1995) Regulation of lymphocyte survival by the BCL-2 gene family. Annu. Rev. Immunol., 13, 513-543.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 513-543
    • Cory, S.1
  • 15
    • 0028113884 scopus 로고
    • R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells
    • Cox, A.D., Brtva, T.R., Lowe, D.G. and Der, C.J. (1994) R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells. Oncogene, 9, 3281-3288.
    • (1994) Oncogene , vol.9 , pp. 3281-3288
    • Cox, A.D.1    Brtva, T.R.2    Lowe, D.G.3    Der, C.J.4
  • 17
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
    • Debbas, M. and White, E. (1993) Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 7, 546-554.
    • (1993) Genes Dev. , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 19
    • 0026722655 scopus 로고
    • Cooperative interaction between c-myc and bcl-2 proto-oncogenes
    • Fanidi, A., Harrington, E.A. and Evan, G.I. (1992) Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature, 359, 554-556.
    • (1992) Nature , vol.359 , pp. 554-556
    • Fanidi, A.1    Harrington, E.A.2    Evan, G.I.3
  • 21
    • 0027440568 scopus 로고
    • Bcl-2 associates with the ras-related protein R-ras p23
    • Fernandez-Sarabia, M.J. and Bischoff, J.R. (1993) Bcl-2 associates with the ras-related protein R-ras p23. Nature, 366, 274-275.
    • (1993) Nature , vol.366 , pp. 274-275
    • Fernandez-Sarabia, M.J.1    Bischoff, J.R.2
  • 22
    • 0029995766 scopus 로고    scopus 로고
    • A license to kill
    • Fraser, A. and Evan, G. (1996) A license to kill. Cell, 85, 781-784.
    • (1996) Cell , vol.85 , pp. 781-784
    • Fraser, A.1    Evan, G.2
  • 23
    • 9544250358 scopus 로고    scopus 로고
    • Bcl-w, a novel member of the bcl-2 family, promotes cell survival
    • Gibson, L. et al. (1996) bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene, 13, 665-675.
    • (1996) Oncogene , vol.13 , pp. 665-675
    • Gibson, L.1
  • 26
    • 0029790857 scopus 로고    scopus 로고
    • Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K
    • Han, J., Sabbatini, P. and White, E. (1996) Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. Mol. Cell. Biol., 16, 5857-5864.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5857-5864
    • Han, J.1    Sabbatini, P.2    White, E.3
  • 27
    • 0029032660 scopus 로고
    • Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax
    • Hanada, M., Aime-Sempe, C., Sato, T. and Reed, J.C. (1995) Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J. Biol. Chem., 270, 11962-11969.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11962-11969
    • Hanada, M.1    Aime-Sempe, C.2    Sato, T.3    Reed, J.C.4
  • 28
    • 0028147070 scopus 로고
    • Programmed cell death in Caenorhabditis elegans
    • Hengartner, M.O. and Horvitz, H.R. (1994) Programmed cell death in Caenorhabditis elegans. Curr. Opin. Genet. Dev., 4, 581-586.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 581-586
    • Hengartner, M.O.1    Horvitz, H.R.2
  • 31
    • 0031020635 scopus 로고    scopus 로고
    • L and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death
    • L and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death. Oncogene. 14. 405-414.
    • (1997) Oncogene. , vol.14 , pp. 405-414
    • Huang, D.C.S.1    Cory, S.2    Strasser, A.3
  • 32
    • 0029928885 scopus 로고    scopus 로고
    • A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis
    • Hunter, J.J. and Parslow, T.G. (1996) A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis. J. Biol. Chem., 271, 8521-8524.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8521-8524
    • Hunter, J.J.1    Parslow, T.G.2
  • 33
    • 0030047365 scopus 로고    scopus 로고
    • Functional dissection of the human Bcl2 protein: Sequence requirements for inhibition of apoptosis
    • Hunter, J.J., Bond, B.L. and Parslow, T.G. (1996) Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis. Mol. Cell. Biol., 16, 877-883.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 877-883
    • Hunter, J.J.1    Bond, B.L.2    Parslow, T.G.3
  • 34
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J.F.R., Wyllie, A.H. and Currie, A.R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 36
    • 0028956550 scopus 로고
    • Regulators of cell death
    • Korsmeyer, S.J. (1995) Regulators of cell death. Trends Genet., 11, 101-105.
    • (1995) Trends Genet. , vol.11 , pp. 101-105
    • Korsmeyer, S.J.1
  • 37
    • 0029069295 scopus 로고
    • ICE-like proteases in apoptosis
    • Kumar, S. (1995) ICE-like proteases in apoptosis. Trends Biochem. Sci., 20, 198-202.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 198-202
    • Kumar, S.1
  • 38
    • 0029789955 scopus 로고    scopus 로고
    • Evidence for α-helical conformation of an essential N-terminal region in the human Bcl2 protein
    • Lee, L.C., Hunter, J.J., Mujeeb, A., Turck, C. and Parslow, T.G. (1996) Evidence for α-helical conformation of an essential N-terminal region in the human Bcl2 protein. J. Biol. Chem., 271, 23284-23288.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23284-23288
    • Lee, L.C.1    Hunter, J.J.2    Mujeeb, A.3    Turck, C.4    Parslow, T.G.5
  • 39
    • 0029166032 scopus 로고
    • Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice
    • Linette, G.P., Hess, J.L., Sentman, C.L. and Korsmeyer, S.J. (1995) Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice. Blood, 86, 1255-1260.
    • (1995) Blood , vol.86 , pp. 1255-1260
    • Linette, G.P.1    Hess, J.L.2    Sentman, C.L.3    Korsmeyer, S.J.4
  • 40
    • 0029843941 scopus 로고    scopus 로고
    • Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation
    • Linette, G.P., Li, Y., Roth, K. and Korsmeyer, S.J. (1996) Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. Proc. Natl Acad. Sci. USA, 93, 9545-9552.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 9545-9552
    • Linette, G.P.1    Li, Y.2    Roth, K.3    Korsmeyer, S.J.4
  • 41
    • 0029077154 scopus 로고
    • Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis
    • Lipponen, P., Pietilainen, T., Kosma, V.M., Aaltomaa, S., Eskelinen, M. and Syrjanen, K. (1995) Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis. J. Pathol., 177, 49-55.
    • (1995) J. Pathol. , vol.177 , pp. 49-55
    • Lipponen, P.1    Pietilainen, T.2    Kosma, V.M.3    Aaltomaa, S.4    Eskelinen, M.5    Syrjanen, K.6
  • 42
    • 0027977928 scopus 로고
    • The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum and the outer mitochondrial membrane
    • Lithgow, T., van Driel, R., Bertram, J.F. and Strasser, A. (1994) The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum and the outer mitochondrial membrane. Cell Growth Differ., 5, 411-417.
    • (1994) Cell Growth Differ. , vol.5 , pp. 411-417
    • Lithgow, T.1    Van Driel, R.2    Bertram, J.F.3    Strasser, A.4
  • 43
    • 0028205733 scopus 로고
    • Growth factor starvation of bcl-2 overexpressing murine bone marrow cells induced refractoriness of IL-3 stimulation of proliferation
    • Marvel, J., Perkins, G.R., Lopez-Rivas, A. and Collins, M.K.L. (1994) Growth factor starvation of bcl-2 overexpressing murine bone marrow cells induced refractoriness of IL-3 stimulation of proliferation. Oncogene, 9, 1117-1122.
    • (1994) Oncogene , vol.9 , pp. 1117-1122
    • Marvel, J.1    Perkins, G.R.2    Lopez-Rivas, A.3    Collins, M.K.L.4
  • 44
    • 0029804050 scopus 로고    scopus 로고
    • Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene
    • Matolcsy, A., Casali, P., Warnke, R.A. and Knowles, D.M. (1996) Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene. Blood, 88, 3937-3944.
    • (1996) Blood , vol.88 , pp. 3937-3944
    • Matolcsy, A.1    Casali, P.2    Warnke, R.A.3    Knowles, D.M.4
  • 45
    • 0029938724 scopus 로고    scopus 로고
    • Regulation of cell division cycle progression by bcl-2 expression: A potential mechanism for inhibition of programmed cell death
    • Mazel, S., Burtrum, D. and Petrie, H.T. (1996) Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death. J. Exp. Med., 183, 2219-2226.
    • (1996) J. Exp. Med. , vol.183 , pp. 2219-2226
    • Mazel, S.1    Burtrum, D.2    Petrie, H.T.3
  • 46
    • 0026053958 scopus 로고
    • Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)
    • McDonnell, T.J. and Korsmeyer, S.J. (1991) Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18). Nature, 349, 254-256.
    • (1991) Nature , vol.349 , pp. 254-256
    • McDonnell, T.J.1    Korsmeyer, S.J.2
  • 48
    • 0024991898 scopus 로고
    • PEF-BOS, a powerful mammalian expression vector
    • Mizushima, J. and Nagata, S. (1990) pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res., 18, 5322.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 5322
    • Mizushima, J.1    Nagata, S.2
  • 49
    • 5244224827 scopus 로고    scopus 로고
    • L, an inhibitor of programmed cell death
    • L, an inhibitor of programmed cell death. Nature, 381, 335-341.
    • (1996) Nature , vol.381 , pp. 335-341
    • Muchmore, S.W.1
  • 51
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti, I., Migliorati, G., Pagliacci, M.C., Grignani, F. and Riccardi, C. (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods, 139, 271-279.
    • (1991) J. Immunol. Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 52
    • 0025255538 scopus 로고
    • Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines
    • Nunez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J.P. and Korsmeyer, S.J. (1990) Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Immunol., 144, 3602-3610.
    • (1990) J. Immunol. , vol.144 , pp. 3602-3610
    • Nunez, G.1    London, L.2    Hockenbery, D.3    Alexander, M.4    McKearn, J.P.5    Korsmeyer, S.J.6
  • 53
    • 0030476922 scopus 로고    scopus 로고
    • The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry
    • O'Reilly, L., Huang, D.C.S. and Strasser, A. (1996) The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J., 15, 6979-6990.
    • (1996) EMBO J. , vol.15 , pp. 6979-6990
    • O'Reilly, L.1    Huang, D.C.S.2    Strasser, A.3
  • 55
    • 0031230361 scopus 로고    scopus 로고
    • Expression of a bcl-2 transgene reduces proliferation and shows turnover of developing B lymphocytes in vivo
    • in press
    • O'Reilly, L.A., Harris, A.W., Tarlinton, D.W., Corcoran, L.M. and Strasser, A. (1997b) Expression of a bcl-2 transgene reduces proliferation and shows turnover of developing B lymphocytes in vivo. J. Immunol., in press.
    • (1997) J. Immunol.
    • O'Reilly, L.A.1    Harris, A.W.2    Tarlinton, D.W.3    Corcoran, L.M.4    Strasser, A.5
  • 56
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai, Z.N., Milliman, C.L. and Korsmeyer, S.J. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell, 74, 609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 57
    • 0025341687 scopus 로고
    • Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation
    • Pezzella, F., Tse, A.G.D., Cordell, J.L., Pulford, K.A.F., Gatter, K.C. and Mason, D.Y. (1990) Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. Am. J. Pathol., 137, 225-232.
    • (1990) Am. J. Pathol. , vol.137 , pp. 225-232
    • Pezzella, F.1    Tse, A.G.D.2    Cordell, J.L.3    Pulford, K.A.F.4    Gatter, K.C.5    Mason, D.Y.6
  • 58
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of programmed cell death
    • Reed, J.C. (1994) Bcl-2 and the regulation of programmed cell death. J. Cell Biol., 124, 1-6.
    • (1994) J. Cell Biol. , vol.124 , pp. 1-6
    • Reed, J.C.1
  • 59
    • 0028847563 scopus 로고
    • Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein
    • Sabbatini, P., Chiou, S.K., Rao, L. and White, E. (1995) Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein. Mol. Cell. Biol., 15, 1060-1070.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1060-1070
    • Sabbatini, P.1    Chiou, S.K.2    Rao, L.3    White, E.4
  • 60
    • 0028136185 scopus 로고
    • Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes
    • Saez, R., Chan, A.M., Miki, T. and Aaronson, S.A. (1994) Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes. Oncogene, 9, 2977-2982.
    • (1994) Oncogene , vol.9 , pp. 2977-2982
    • Saez, R.1    Chan, A.M.2    Miki, T.3    Aaronson, S.A.4
  • 61
    • 0030614915 scopus 로고    scopus 로고
    • L-Bak peptide complex: Recognition between regulators of apoptosis
    • L-Bak peptide complex: recognition between regulators of apoptosis. Science, 275, 983-986.
    • (1997) Science , vol.275 , pp. 983-986
    • Sattler, M.1
  • 62
    • 0028238213 scopus 로고
    • Immediate early up-regulation of bax expression by p53 but not TGFβ1: A paradigm for distinct apoptotic pathways
    • Selvakumaran, M., Lin, H.-K., Miyashita, T. Wang, H.G., Krajewski, S., Reed, J.C., Hoffman, B. and Liebermann, D. (1994) Immediate early up-regulation of bax expression by p53 but not TGFβ1: a paradigm for distinct apoptotic pathways. Oncogene, 9, 1791-1798.
    • (1994) Oncogene , vol.9 , pp. 1791-1798
    • Selvakumaran, M.1    Lin, H.-K.2    Miyashita, T.3    Wang, H.G.4    Krajewski, S.5    Reed, J.C.6    Hoffman, B.7    Liebermann, D.8
  • 63
    • 0031019739 scopus 로고    scopus 로고
    • Interaction between the C.elegans cell-death regulators CED-9 and CED-4
    • Spector, M.S., Desnoyers, S., Hoeppner, D.J. and Hengartner, M.O. (1997) Interaction between the C.elegans cell-death regulators CED-9 and CED-4. Nature, 385, 653-656.
    • (1997) Nature , vol.385 , pp. 653-656
    • Spector, M.S.1    Desnoyers, S.2    Hoeppner, D.J.3    Hengartner, M.O.4
  • 64
    • 0025251664 scopus 로고
    • Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    • Strasser, A., Harris, A.W., Bath, M.L. and Cory, S. (1990) Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature, 348, 331-333.
    • (1990) Nature , vol.348 , pp. 331-333
    • Strasser, A.1    Harris, A.W.2    Bath, M.L.3    Cory, S.4
  • 65
    • 0027461627 scopus 로고
    • Eμ-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells
    • Strasser, A., Harris, A.W. and Cory, S. (1993) Eμ-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells. Oncogene, 8, 1-9.
    • (1993) Oncogene , vol.8 , pp. 1-9
    • Strasser, A.1    Harris, A.W.2    Cory, S.3
  • 66
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
    • Strasser, A., Harris, A.W., Jacks, T. and Cory, S. (1994) DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2, Cell, 79, 329-339.
    • (1994) Cell , vol.79 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jacks, T.3    Cory, S.4
  • 67
    • 0029609086 scopus 로고
    • Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    • Strasser, A., Harris, A.W., Huang, D.C.S., Krammer, P.H. and Cory, S. (1995) Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J., 14, 6136-6147.
    • (1995) EMBO J. , vol.14 , pp. 6136-6147
    • Strasser, A.1    Harris, A.W.2    Huang, D.C.S.3    Krammer, P.H.4    Cory, S.5
  • 68
    • 0028847915 scopus 로고
    • Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity
    • Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, S., Millan, J.A. and Reed, J.C. (1995) Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell, 80, 279-284.
    • (1995) Cell , vol.80 , pp. 279-284
    • Takayama, S.1    Sato, T.2    Krajewski, S.3    Kochel, K.4    Irie, S.5    Millan, J.A.6    Reed, J.C.7
  • 69
    • 0026551831 scopus 로고
    • Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas
    • Tanaka, S., Louie, D.C., Kant, J.A. and Reed, J.C. (1992) Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas. Blood, 79, 229-237.
    • (1992) Blood , vol.79 , pp. 229-237
    • Tanaka, S.1    Louie, D.C.2    Kant, J.A.3    Reed, J.C.4
  • 70
    • 0029867242 scopus 로고    scopus 로고
    • Unmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1
    • Theodorakis, P., D'Sa-Eipper, C., Subramanian, T. and Chinnadurai, G. (1996) Unmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1. Oncogene, 12, 1707-1713.
    • (1996) Oncogene , vol.12 , pp. 1707-1713
    • Theodorakis, P.1    D'Sa-Eipper, C.2    Subramanian, T.3    Chinnadurai, G.4
  • 71
    • 0021679848 scopus 로고
    • Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
    • Tsujimoto, Y., Finger, L.R., Yunis, J., Nowell, P.C. and Croce, C.M. (1984) Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science, 226, 1097-1099.
    • (1984) Science , vol.226 , pp. 1097-1099
    • Tsujimoto, Y.1    Finger, L.R.2    Yunis, J.3    Nowell, P.C.4    Croce, C.M.5
  • 72
    • 0029895458 scopus 로고    scopus 로고
    • Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: Suppression of apoptosis with concomitant cell proliferation
    • Uhlmann, E.J., D'Sa-Eipper, C., Subramanian, T., Wagner, A.J., Hay, N. and Chinnadurai, G. (1996) Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation. Cancer Res., 56, 2506-2509.
    • (1996) Cancer Res. , vol.56 , pp. 2506-2509
    • Uhlmann, E.J.1    D'Sa-Eipper, C.2    Subramanian, T.3    Wagner, A.J.4    Hay, N.5    Chinnadurai, G.6
  • 73
    • 0029805403 scopus 로고    scopus 로고
    • Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival
    • Vairo, G., Innes, K.M. and Adams, J.M. (1996) Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival. Oncogene, 13, 1511-1519.
    • (1996) Oncogene , vol.13 , pp. 1511-1519
    • Vairo, G.1    Innes, K.M.2    Adams, J.M.3
  • 74
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux, D.L., Cory, S. and Adams, J.M. (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature, 335, 440-442.
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 75
    • 0028144848 scopus 로고
    • Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase
    • Wang, H.-G. et al. (1994) Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene, 9, 2751-2756.
    • (1994) Oncogene , vol.9 , pp. 2751-2756
    • Wang, H.-G.1
  • 76
    • 0029029743 scopus 로고
    • R-ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism
    • Wang, H.-G., Millan, J.A., Cox, A.D., Der, C.J., Rapp, U.R., Beck, T., Zha, H. and Reed, J.C. (1995) R-ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism. J. Cell Biol., 129, 1103-1114.
    • (1995) J. Cell Biol. , vol.129 , pp. 1103-1114
    • Wang, H.-G.1    Millan, J.A.2    Cox, A.D.3    Der, C.J.4    Rapp, U.R.5    Beck, T.6    Zha, H.7    Reed, J.C.8
  • 78
    • 0030004255 scopus 로고    scopus 로고
    • Abrogation of p53-induced G1 arrest by the HPV 16 E7 protein does not inhibit p53-induced apoptosis
    • Wang, Y., Okan, I., Pokrovskaja, K. and Wiman, K.G. (1996) Abrogation of p53-induced G1 arrest by the HPV 16 E7 protein does not inhibit p53-induced apoptosis. Oncogene, 12, 2731-2735.
    • (1996) Oncogene , vol.12 , pp. 2731-2735
    • Wang, Y.1    Okan, I.2    Pokrovskaja, K.3    Wiman, K.G.4
  • 79
    • 0030046508 scopus 로고    scopus 로고
    • Life, death, and the pursuit of apoptosis
    • White, E. (1996) Life, death, and the pursuit of apoptosis. Genes Dev., 10, 1-15.
    • (1996) Genes Dev. , vol.10 , pp. 1-15
    • White, E.1
  • 80
    • 0031020227 scopus 로고    scopus 로고
    • Interaction and regulation of subcellular localization of CED-4 by CED-9
    • Wu, D., Wallen, H.D. and Nuñez, G. (1997) Interaction and regulation of subcellular localization of CED-4 by CED-9. Science, 275, 1126-1129.
    • (1997) Science , vol.275 , pp. 1126-1129
    • Wu, D.1    Wallen, H.D.2    Nuñez, G.3
  • 81
    • 0029880987 scopus 로고    scopus 로고
    • The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
    • Xue, D., Shaham, S. and Horvitz, H.R. (1996) The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev., 10, 1073-1083.
    • (1996) Genes Dev. , vol.10 , pp. 1073-1083
    • Xue, D.1    Shaham, S.2    Horvitz, H.R.3
  • 82
    • 0029899181 scopus 로고    scopus 로고
    • Molecular thanatopsis: A discourse on the Bcl-2 family and cell death
    • Yang, E. and Korsmeyer, S.J. (1996) Molecular thanatopsis: a discourse on the Bcl-2 family and cell death. Blood, 88, 386-401.
    • (1996) Blood , vol.88 , pp. 386-401
    • Yang, E.1    Korsmeyer, S.J.2
  • 84
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
    • Yin, X.-M., Oltvai, Z.N. and Korsmeyer, S.J. (1994) BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature, 369, 321-323.
    • (1994) Nature , vol.369 , pp. 321-323
    • Yin, X.-M.1    Oltvai, Z.N.2    Korsmeyer, S.J.3
  • 85
    • 0027525104 scopus 로고
    • The C.elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
    • Yuan, J., Shaham, S., Ledoux, S., Ellis, H.M. and Horvitz, H.R. (1993) The C.elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell, 75, 641-652.
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5
  • 86
    • 0029917541 scopus 로고    scopus 로고
    • Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2
    • Zha, H., Aimé-Sempé, C., Sato, T. and Reed, J.C. (1996) Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J. Biol. Chem., 271, 7440-7444.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7440-7444
    • Zha, H.1    Aimé-Sempé, C.2    Sato, T.3    Reed, J.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.