Transfection of c6 glioma cells with the bax gene and increased sensitivity to treatment with cytosine arabinoside

Journal of Neurosurgery

Volumn 88, Issue 1, 1998, Pages 99-105

  Vogelbaum, Michael A ^a   Tong, Jianxian X ^a   Higashikubo, Ryugi ^a   Gutman, David H ^a   Rich, Keith M ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl 2 gene family; Brain tumor; Cell cycle; Chemotherapy; Gene therapy; Rat

Indexed keywords

CYTARABINE; PROTEIN BAX;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; GENETIC TRANSFECTION; GLIOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031975163     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.1998.88.1.0099     Document Type: Article

References (40)

1. Alderson LM, Castleberg RL, Harsh GR IV, et al: Human gliomas with wild-type p53 express bcl-2. Cancer Res 55: 999-1001, 1995
2. Anker L, Ohgaki H, Ludeke BI, et al: p53 protein accumulation and gene mutations in human glioma cell lines. Int J Cancer 55:982-987, 1993
3. Asai A, Miyagi Y, Sugiyama A, et al: Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. J Neurooncol 19:259-268, 1994
4. Bargou RC, Wagener C, Bommert K, et al: Overexpression of the death-promoting gene bax-α which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J Clin Invest 97: 2651-2659, 1996
5. Boise LH, González-García M, Postema CE, et al: bcl-x a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597-608, 1993
6. Borner C: Diminished cell proliferation associated with the death-protective activity of Bcl-2. J Biol Chem 271: 12695-12698, 1996
7. Brady HJM, Gil-Gómez G, Kirberg J, et al: Bax-α perturbs T cell development and affects cell cycle entry of T cells. EMBO J 15:6991-7001, 1996
8. Chiou SK, Rao L, White E: bcl-2 blocks p53-dependent apoptosis. Mol Cell Biol 14:2556-2563, 1994
9. Chou D, Miyashita T, Mohrenweiser HW, et al: The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas. Cancer Genet Cytogenet 88: 136-140, 1996
10. Dole M, Nuñez G, Merchant AK, et al: bcl-2 protein inhibits chemotherapy-induced apoptosis in neuroblastoma. Cancer Res 54:3253-3259, 1994
11. Gomez-Manzano C, Fueyo J, Kyritsis AP, et al: Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 56:694-699, 1996
12. Hamilton HB, Hinton DR, Law RE, et al: Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. J Neurosurg 85:329-334, 1996
13. Hockenbery DM : bcl-2 in cancer, development and apoptosis. J Cell Sci 18 (Suppl):51-55, 1994
14. Ikemoto H, Tani E, Matsumoto T, et al: Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor. J Neurosurg 83:1008-1016, 1995
15. Knudson CM, Tung KSK, Tourtellotte WG, et al: Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96-99, 1995
16. Kondo S, Barna BP, Kondo Y, et al: WAF1/CIP1 increases the susceptibility of p53 non-functional malignant glioma cells to cisplatin-induced apoptosis. Oncogene 13:1279-1285, 1996
17. Kondo S, Barnett GH, Hara H, et al: MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis. Oncogene 10:2001-2006, 1995
18. Lotem J, Sachs L: Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. Cell Growth Diff 4:41-47, 1993
19. Lowe SW, Ruley HE, Jacks T, et al: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967, 1993
20. Merzak A, Raynal S, Rogers JP, et al: Human wild type p53 inhibits cell proliferation and elicits dramatic morphological changes in human glioma cell lines in vitro. J Neurol Sci 127:125-133, 1994
21. Miyashita T, Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80:293-299, 1995
22. Motoyama N, Wang F, Roth KA, et al: Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267:1506-1510, 1995
23. Murai N, Ueba T, Takahashi JA, et al: Apoptosis of human glioma cells in vitro and in vivo induced by a neutralizing antibody against human basic fibroblast growth factor. J Neurosurg 85:1072-1077, 1996
24. Oltvai ZN, Korsmeyer SJ: Checkpoints of dueling dimers foil death wishes. Cell 79:189-192, 1994
25. Oltvai ZN, Milliman CL, Korsmeyer SJ: bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programed cell death. Cell 74:609-619, 1993
26. O'Reilly LA, Huang DCS, Strasser A: The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J 15:6979-6990, 1996
27. Ram Z, Culver KW, Walbridge S, et al: In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 53:83-88, 1994
28. Rubio MP, von Deimling A, Yandell DW, et al: Accumulation of wild type p53 protein in human astrocytomas. Cancer Res 53:3465-3467, 1993
29. Rutka JT, Hubbard SL, Fukuyama K, et al: Effects of antisense glial fibrillary acidic protein complementary DNA on the growth, invasion, and adhesion of human astrocytoma cells. Cancer Res 54:3267-3272, 1995
30. Sakakura C, Sweeney EA, Shirahama T, et al: Overexpression of bax sensitizes human breast cancer MCF-7 cells to radiation-induced apoptosis. Int J Cancer 67:101-105, 1996
31. Scragg MA, Ferreira LR: Evaluation of different staining procedures for the quantification of fibroblasts cultured in 96-well plates. Anal Biochem 198:80-85, 1991
32. Strobel T, Swanson L, Korsmeyer S, et al: BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc Natl Acad Sci USA 93:14094-14099, 1996
33. Tornusciolo DR, Schmidt RE, Roth KA: Simultaneous detection of TDT-mediated dUTP-biotin nick end-labeling (TUNEL)-positive cells and multiple immunohistochemical markers in single tissue sections. Biotechniques 19:800-805, 1995
34. Tsujimoto Y, Finger LR, Yunis J, et al: Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097-1099, 1984
35. Van Meir EG, Kikuchi T, Tada M, et al: Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res 54:649-652, 1994
36. Vaux DL, Cory S, Adams JM: "bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442, 1988
37. von Deimling A, Louis DN, Wiestler OD: Molecular pathways in the formation of gliomas. Glia 15:328-338, 1995
38. Wagener C, Bargou RC, Daniel PT, et al: Induction of the death-promoting gene bax-α sensitizes cultured breast-cancer cells to drug-induced apoptosis. Int J Cancer 67:138-141, 1996
39. Weller M, Malipiero U, Aguzzi A, et al: Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation. J Clin Invest 95:2633-2643, 1995
40. Yu JS, Sena-Estaves M, Paulus W, et al: Retroviral delivery and tetracycline-dependent expression of IL-1beta-converting enzyme (ICE) in a rat glioma model provides controlled induction of apoptotic death in tumor cells. Cancer Res 56: 5423-5427, 1996