Involvement of cyclin D1-CDK5 overexpression and MCM3 cleavage in bax- associated spontaneous apoptosis and differentiation in an A253 human head and neck carcinoma xenograft model

International Journal of Cancer

Volumn 83, Issue 3, 1999, Pages 341-348

  Yin, Ming Biao ^a   Tóth, Károly ^a   Cao, Shousong ^a   Guo, Bin ^a   Frank, Cheryl ^a   Slocum, Harry K ^a   Rustum, Youcef M ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; DNA FRAGMENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; REGULATOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HEAD CANCER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MOUSE; NECK CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SQUAMOUS CELL CARCINOMA; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 1; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CYCLIN D1; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; DNA FRAGMENTATION; DNA-BINDING PROTEINS; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0345062128     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19991029)83:3<341::AID-IJC9>3.0.CO;2-3     Document Type: Article

References (24)

1. ALMASAN, A., YIN, Y., KELLY, R.E., LEE, E.Y., BRADLEY, A., LI, W., BERTINO, J.R. and WAHL, G.M., Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc. nat. Acad. Sci. (Wash.), 92, 5435-5440 (1995).
2. AN, B. and DOU, Q.P., Cleavage of retinoblastoma protein during apoptosis: an interleukin 1 β-converting enzyme-like protease as candidate. Cancer Res., 56, 438-442 (1996).
3. CHEN, W.D., OTTERSON, G.A., LIPKOWITZ, S., KHLEIF, S.N., COXON, A.B. and KAYE, F.J., Apoptosis is associated with cleavage of a 5 kDa fragment from RB which mimics dephosphorylation and modulates E2F binding. Oncogene, 14, 1243-1248 (1997).
4. EWEN, M.E., SLUSS, H.K., SHERR, C.J., MATSUSHIME, H., KATO, J.Y. and LIVINGSTON, D.M., Functional interaction of the retinoblastoma protein with mammalian D-type cyclins. Cell, 73, 481-497 (1993).
5. HAAS-KOGAN, D.A., KOGAN, S.C., LEVI, D., DAZIN, P., T'ANG, A., FUNG, Y.K. and ISRAEL, M.A., Inhibition of apoptosis by the retinoblastoma gene product. EMBO J., 14, 461-472 (1995).
6. kip1, inhibits growth and enhances apoptosis. Cell Growth Differentiation, 7, 699-710 (1996).
7. 1 cyclins, cdk 2, and cyclin A during the differentiation of HL60 cells induced by TPA. Mol. cell. Biochem., 132, 31-37 (1994).
8. HU, B., BURKHART, R., SCHULTE, D., MUSAHL, C. and KNIPPERS, R., The P1 family: a new class of nuclear mammalian proteins related to the yeast MCM replication protein. Nucleic Acids Res., 21, 5289-5293 (1993).
9. JANICKE, R.U., WALKER, P.A., LIN, X.Y. and PORTER, A.G., Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis. EMBO J., 15, 6969-6978 (1996).
10. KEARSEY, S.E., MAIORANO, D., HOLMES, E.C. and TODOROV, I.T., The role of MCM proteins in the cell cycle control of genome duplication. BioEssays, 18, 183-190 (1996).
11. KOIKE, M., Significance of spontaneous apoptosis during colorectal tumorigenesis. J. surg. Oncol., 62, 97-108 (1996).
12. KRANENBURG, O., VAN DER EB, A.J. and ZANTEMA, A., Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J., 15, 46-54 (1996).
13. LI, Z., HROMCHAK, R. and BLOCH, A., Differential expression of proteins regulating cell cycle progression in growth vs. differentiation. Biochim. biophys. Acta, 1356, 149-159 (1997).
14. MARTIN, S.J. and GREEN, D.R., Protease activation during apoptosis: death by a thousand cuts? Cell. 82, 349-352 (1995).
15. MIYASHITA, T. and REED, J.C., Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80, 293-299 (1995).
16. NICHOLSON, D.W., ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis. Nature (Biotech.), 14, 297-301 (1996).
17. NICHOLSON, D.W. and 14 OTHERS, Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (Lond.), 376, 37-43 (1995).
18. REED, J.C., Bcl-2 and the regulation of programmed cell death. J. Cell Biol., 124, 1-6 (1994).
19. SCHWAB, B.L., LEIST, M., KNIPPERS, R. and NICOTERA, P., Selective proteolysis of the nuclear replication factor MCM3 in apoptosis. Exp. Cell Res., 238, 415-421 (1998).
20. SHIMIZU, S., EGUCHI, Y., KAMIIKE, W, MATSUDA, H. and TSUJIMOTO, Y., Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene, 12, 2251-2257 (1996).
21. TEWARI, M., QUAN, L.T., O'ROURKE, K., DESNOYERS, S., ZENG, Z., BEIDLER, D.R., POIRIER, G.G., SALVESEN, G.S. and DIXIT, V.M., Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell, 81, 801-809 (1995).
22. TSAI, L.-H., TAKAHASHI, T., CAVINESS, V.S., JR. and HARLOW, E., Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development, 119, 1029-1040 (1993).
23. WILHIDE, C.C., VAN DANG, C., DIPERSIO, J., KENEDY, A.A. and BRAY, P.F., Overexpression of cyclin D1 in the Dami megakaryocytic cell line causes growth arrest. Blood, 86, 294-304 (1995).
24. ZHANG, Q., AHUJA, H.S., ZAKERI, Z.F. and WOLGEMUTH, D.J., Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling. Development. Biol., 183, 222-233 (1997).