The kinetic factors that determine the affinity and selectivity for slow binding inhibition of human prostaglandin H synthase 1 and 2 by indomethacin and flurbiprofen

Journal of Biological Chemistry

Volumn 271, Issue 7, 1996, Pages 3548-3554

  Callan, Ondine Harris ^a   So, On Yee ^a   Swinney, David C ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLURBIPROFEN; INDOMETACIN; PROSTAGLANDIN SYNTHASE;

ARTICLE; BINDING AFFINITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME KINETICS; ISOMERISM; MATHEMATICAL MODEL; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

CYCLOOXYGENASE INHIBITORS; FLURBIPROFEN; HUMANS; INDOMETHACIN; ISOENZYMES; KINETICS; MATHEMATICS; MODELS, THEORETICAL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 0030063502     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.7.3548     Document Type: Article

References (22)

1. Vane, J R. (1971) Nature New Biol. 231, 232-235
2. Xie, W., Chipman, J. G., Robertson, D. L., Erikson, R. L., and Simmons, D. L. (1991) Proc. Natl Acad. Sci. U. S. A. 88, 2692-2696
3. Vane, J. R. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 2046-1050
4. Xie, W., Robertson, D. L., and Simmons, D. L. (1992) Drug Dev. Res. 25, 249-265
5. Mitchell, J. A., Akarasereenont, P., Thiemermann, C., Flower, R. J., and Vane, J. R (1993) Proc Natl. Acad. Sci. U. S A. 90, 11693-11697
6. Rome, L H., and Lands, W. E. M. (1975) Proc. Natl. Acad Sci. U. S. A 72, 4863-4865
7. Kulmacz, R. J., and Lands, W. E. M. (1985) J. Biol. Chem. 260, 12572-12578
8. Morrison, J. F., and Walsh, C. T. (1988) Adv. Enzymol. Relat. Areas Mol. Biol. 61, 201-301
9. Walenga, R W., Hall, S. F , Setty, B. N. Y., and Stuart, M. J. (1986) Prostaglandins 31, 625-637
10. Barnett, J., Chow, J., Ives, D., Chiou, M., Mackenzie, R., Osen, E , Nguyen, B., Tsing, S., Bach, C., Freire, J., Chan, H., Sigal, E., and Ramesha, C. (1994) Biochim. Biophys. Acta 1209, 130-139
11. Quellet, M., and Percival, M D. (1995) Biochem. J 306, 247-251
12. Morrison, J. F. (1982) Trends Biochem. Sci. 7 102-105
13. Picot, D., Loll, P. J., and Garavito, R M. (1994) Nature 367, 243-249
14. Izquierdo-Martin, M., Chapman, K. T, Hagmann, W. K., and Stern, R. L (1994) Biochemistry 33, 1306-1365
15. Bartlett, P. A., and Marlowe, C. K. (1987) Biochemistry 26, 8553-8561
16. Cho, Y.-K., Rebholz, K. L , and Northrop, D B. (1994) Biochemistry 33, 9637-9642
17. O'Neill, G. P., Mancini, J. A., Kargman, S., Yergey, J., Kwan, M. Y., Falgueyret, J.-P., Abramovitz, M., Kennedy, B. P., Quellet, M., Cromlish, W., Gulp, S., Evans, J. F., Ford-Hutchinson, A. W., and Vickers, P. J. (1994) Mol Pharmacol 45, 245-254
18. Glaser, K., Sung, M.-L., O'Neill, K, Belfast, M , Hartman, D , Carlson, R., Kreft, A., Kubrak, D., Hsiao, C.-L., and Weichman, B. (1995) Eur. J. Pharmacol. 281, 107-111
19. Laneuville, O., Breuer, D. K., Dewitt, D. L., Hla, T , Funk, C. D., and Smith, W. L. (1994) J. Pharmacol. Exp. Ther. 271, 927-934
20. Patrignani, P., Panara, M. R., Greco, A., Fusco, O., Natoli, C., Iacobelli, S., Cipollone, F., Ganci, A., Creminon, C., Maclouf, J., and Patrono, C. (1994) J. Pharmacol. Exp. Ther. 271, 1705-1712
21. Chan, C -C., Boyce, S., Brideau, C., Ford-Hutchinson, A. W., Gordon, R., Guay, D , Hill, R. G., Li, C -S., Mancini, J., Penneton, M., Prasit, P , Rasori, R., Riendeau, D., Roy, P., Tagari, P., Vickers, P., Wong, E., and Rodger, I. W. (1995) J. Pharmacol. Exp. Ther. 274, 1531-1537
22. Copeland, R. A., Williams, J. M , Giannaras, J , Nurnberg, S., Covington, M., Pinto, D., Pick, S., and Trzaskos, T. M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 11202-11206