Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site

Journal of Biological Chemistry

Volumn 275, Issue 7, 2000, Pages 4743-4746

  Schneider, Claus ^a   Brash, Alan R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 2; HYDROGEN; HYDROXYICOSATETRAENOIC ACID;

ACETYLATION; ARTICLE; ENZYME ACTIVE SITE; OXYGENATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; REACTION ANALYSIS; REOXYGENATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STEREOCHEMISTRY; STEREOSPECIFICITY;

ACETYLATION; ARACHIDONIC ACID; ASPIRIN; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 2; HYDROGEN; HYDROXYEICOSATETRAENOIC ACIDS; ISOENZYMES; MODELS, CHEMICAL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SUBSTRATE SPECIFICITY;

TRITIUM;

EID: 0034681359     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.7.4743     Document Type: Article

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