Dynamics of prostaglandin H synthases. Studies with prostaglandin H synthase 2 Y355F unmask mechanisms of time-dependent inhibition and allosteric activation

Journal of Biological Chemistry

Volumn 273, Issue 10, 1998, Pages 5801-5807

  So, On Yee ^a   Scarafia, Liliana E ^a   Mak, Amy Y ^a   Callan, Ondine H ^a   Swinney, David C ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTAGLANDIN SYNTHASE;

ALLOSTERISM; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

ALLOSTERIC REGULATION; ARACHIDONIC ACID; BINDING SITES; CATALYSIS; CYCLOOXYGENASE INHIBITORS; ENZYME ACTIVATION; HYDROGEN BONDING; INDOMETHACIN; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXYGEN; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; THERMODYNAMICS; TYROSINE;

EID: 0032489522     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.10.5801     Document Type: Article

References (32)

1. Smith, W. L., Garavito, R. M., and DeWitt, D. L. (1996) J. Biol. Chem. 271, 33157-33160
2. Flower, R. J., Gryglewski, R., Herbaczynska-Cedro, K., and Vane J. R. (1972) Nature 238, 104-106
3. Seibert, K., Zhang, Y., Leahy, K., Hauser, S., Masferrer, J., Perkins, W., Lee, L., and Isakson, P. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 12013-12017
4. Chan, C. C., Boyce, S., Brideau, C., Ford-Hutchinson, A. W., Gordon, R., Guay, D., Hill, R. G., Li, C. S., Mancini, J., Penneton, M., Prasit, P., Rasori, R., Riendeau, D., Roy, P., Tagari, P., Vickers, P., Wong, E., and Rodger, I. W. (1995) J. Pharmacol. Exp. Ther. 274, 1531-1537
5. Kutchera, W., Jones, D. A., Matsunami, N., Groden, J., McIntyre, T. M., Zimmerman, G. A., White, R. L., and Prescott, S. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 4816-4820
6. DuBois, R. N., Radhika, A., Reddy, B. S., and Entingh, A. J. (1996) Gastroenterology 110, 1259-1262
7. Breitner, J. C., Gau, B. A., Welsh, K. A., Plassman, B. L., McDonald, W. M., Helms, M. J., and Anthony, J. C. (1994) Neurology 44, 227-232
8. Picot, D., Loll, P. J., and Garavito, R. M. (1994) Nature 367, 243-249
9. Kurumbail, R. G., Stevens, A. M., Gierse, J. K., McDonald, J. J., Stegeman, R. A., Pak, J. Y., Gildehaus, D., Miyashiro, J. M., Penning, T. D., Seibert, K., Isakson, P. C., and Stallings, W. C. (1996) Nature 384, 544-648
10. Luong, C., Miller, A., Barnett, J., Chow, J., Ramesha, C., and Browner, M. F., (1996) Nat. Struct. Biol. 3, 927-933
11. Loll, P. J., Picot, D., Ekabo, O., and Garavito, R. M. (1996) Biochemistry 35, 7330-7440
12. Mancini, J. A., Riendeau, D., Falgueyret, J.-P., Vickers, P. J., and O'Neill, G. P. (1995) J. Biol. Chem. 270, 29372-29377
13. Bhattacharyya, D. K., Lecomte, M., Rieke, C. J., Garavito, R. M., and Smith, W. L. (1996) J. Biol. Chem. 271, 2179-2184
14. Shimokawa, T., Kuylmacz, R. J., DeWitt, D. L., and Smith, W. L. (1990) J. Biol. Chem. 265, 20073-20076
15. Gierse, J. K., McDonald, J. J., Hauser, S. D., Rangwala, S. H., Koboldt, C. M., and Seibert, K (1996) J. Biol. Chem. 271, 15810-15814
16. Wong, E., Bayly, C., Waterman, H. L., Riendeau, D., and Mancini, J. A. (1997) J. Biol. Chem. 272, 9280-9286
17. Quo, Q., Wang, L.-H., Ruan, K.-H., and Kulmacz, R. J. (1996) J. Biol. Chem. 271, 19134-13139
18. Rome, L. H., and Lands, W. E. M. (1975) Proc. Natl. Acad. Sci. U. S. A. 72, 4863-4865
19. Kulmacz, R. J., and Lands, W. E. M. (1985) J. Biol. Chem. 260, 12572-12578
20. Laneuville, O., Breuer, D. K., Dewitt, D. L., Hla, T., Funk, C. D., and Smith, W. L. (1994) J. Pharm. Exp. Ther. 271, 927-934
21. Copeland R. A., Williams, J. M., Giannaras, J., Nurnberg, S., Covington, M., Pinto, D., Pick, S., and Trzaskos, J. M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 11202-11206
22. Swinney, D. C., Mak, A. Y., Barnett, J., and Ramesha, C. S. (1997) J. Biol. Chem. 272, 12393-12398
23. Morrison, J. F., and Walsh, C. T. (1988) Adv. Enzymol. Relat. Areas Mol. Biol. 61, 201-301
24. Callan, O. H., So, O.-Y., and Swinney D. C. (1996) J. Biol. Chem. 271, 3548-3554
25. Yu, M., Ives, D., and Ramesha, C. S. (1997) J. Biol. Chem. 272, 21181-21186
26. Barnett, J., Chow, J., Ives, D., Chou, M., Mackenzie, R., Osen, E., Nguyen, B., Tsing, S., Bach, C., Freire, J., Chan, H., Sigal, E., and Ramesha, C. (1994) Biochim. Biophys. Acta 1209, 130-139
27. Sloane, D. L., So, O.-Y., Leung, R., Scarafia, L. E., Saldou, N., Jarnagin, K., and Swinney, D. C. (1995) Gene (Amst.) 161, 243-248
28. Kulmacz, R. J. (1987) Prostaglandins 34, 225-240
29. Kulmacz, R. J., and Lands, W. E. M. (1984) J. Biol. Chem. 259, 6358-6363
30. Wilkinson, A. J., Fersht, A. R., Blow, D. M., and Winter, G. (1983) Biochemistry 22, 3581-3586
31. Rich, D. H., and Northrop, D. B. (1989) in Computer-aided Drug Design (Perun, T. J., and Propst, C. L., eds) pp. 185-250, Marcel Dekker, Inc., New York
32. Reitz, D. B., Li, J. J., Norton, M. B., Reinhard, E. J., Collins, J. T., Anderson, G. D., Gregory, S. A., Kodolt, C. M., Perkins, W. E., Seibert, K., and Isakson, P. C. (1994) J. Med. Chem. 37, 3878-3881