Somatic mutagenesis and evolution of memory B cells

Current Topics in Microbiology and Immunology

Volumn 229, Issue , 1997, Pages 105-131

  Wysocki, L J ^a,b   Liu, A H ^a,b   Jena, P K ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; B LYMPHOCYTE; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MEMORY CELL; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; REVIEW; SOMATIC MUTATION;

ANIMALS; B-LYMPHOCYTES; CELL DIVISION; EVOLUTION; HUMANS; IMMUNOLOGIC MEMORY; MUTAGENESIS; SELECTION (GENETICS);

ANIMALIA;

EID: 0031442168     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (8)

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3. Azuma T, Motoyama N, Fields LE, Loh DY (1993) Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer. Int Immunol 5:121-130
4. Berek C, Milstein C (1987) Mutation drift and repertoire shift in the maturation of the immune response. Immunol Rev 96:23-41
5. Wysocki LJ, Gefter ML, Margolies MN (1990) Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VII genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversion. J Exp Med 172:315-323
6. Xu B, Selsing E (1994) Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene. Science 265:1590-1593
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8. Zhang J, MacLennan IC, Liu YJ, Lane PJ (1988) Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones? Immunol Lett 18:297-299