A new view of V(D)J recombination

Genes to Cells

Volumn 1, Issue 3, 1996, Pages 269-275

  Gellert, Martin ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; RAG 1 PROTEIN; RAG-1 PROTEIN; V(D)J RECOMBINATION ACTIVATING PROTEIN 2;

ANIMAL; GENETIC RECOMBINATION; GENETICS; PHYSIOLOGY; REVIEW;

ANIMALS; DNA-BINDING PROTEINS; HOMEODOMAIN PROTEINS; RECEPTORS, ANTIGEN; RECOMBINATION, GENETIC;

EID: 0030089703     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1996.22023.x     Document Type: Review

References (40)

1. Biedermann, K.A., Sun, J.R., Giaccia, A.J., Tosto, L.M. & Brown, J.M. (1991) scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc. Natl Acad. Sci. USA 88, 1394-1397.
2. Blunt, T., Finnie, N.J., Taccioli, G.E., Smith, G.C.M., Demengeot, J., Gottlieb, T., Mizuta, R., Varghese, A.J., Alt, F.W., Jeggo, P.A. & Jackson, S.P. (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823.
3. Chen, Y.Y., Wang, L.C., Huang, M.S. & Rosenberg, N. (1994) An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement. Genes Dev. 8, 688-697.
4. Cuomo, C.A. & Oettinger, M.A. (1994) Analysis of regions of RAG-2 important for V(D)J recombination. Nucl. Acids Res. 22, 1810-1814.
5. Engelman, A., Mizuuchi, K. & Craigie, R. (1991) HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer. Cell 67, 1211-1221.
6. Fulop, G.M. & Phillips, R.A. (1990) The scid mutation in mice causes a general defect in DNA repair. Nature 347, 479-482.
7. Gellert, M. (1992) Molecular analysis of V(D)J recombination. Annu. Rev. Genet. 22, 425-446.
8. Hartley, K.O., Gell, D., Smith, G.C., Zhang, H., Divecha, N., Connelly, M.A., Admon, A., Lees-Miller, S.P., Anderson, C.W. & Jackson, S.P. (1995) DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82, 849-856.
9. Hendrickson, E.A., Qin, X.-Q., Bump, E.A., Schatz, D.G., Oettinger, M.A. & Weaver, D.T. (1991) A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proc. Natl Acad. Sci. USA 88, 4061-4065.
10. Kirchgessner, C.U., Patil, C.K., Evans, J.W., Cuomo, C.A., Fried, L.M., Carter, T., Oettinger, M.A. & Brown, J.M. (1995) DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267, 1178-1183.
11. Lafaille, J.J., DeCloux, A., Bonneville, M., Takagaki, Y. & Tonegawa, S. (1989) Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining. Cell 59, 859-870.
12. Lewis, S.M. (1994) The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses. Adv. Immunol. 56, 27-150.
13. Li, Z., Otevrel, T., Gao, Y., Cheng, H.-L., Seed, B., Stamato, T.D., Taccioli, G.E. & Alt, F.W. (1995) The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 83, 79-89.
14. Lieber, M.R., Hesse, J.E., Lewis, S., Bosma, G.C., Rosenberg, N., Mizuuchi, K., Bosma, M.J. & Gellert, M. (1988) The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination. Cell 55, 7-16.
15. McBlane, J.F., van Gent, D.C., Ramsden, D.A., Romeo, C., Cuomo, C.A., Gellert, M. & Oettinger, M.A. (1995) Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83, 387-395.
16. McCormack,W.T., Tjoelker, L.W., Carlson, L.M., Petryniak, B., Barth, C.F., Humphries, E.H. & Thompson, C.B. (1989) Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments. Cell 56, 785-791.
17. Mizuuchi, K. & Adzuma, K. (1991) Inversion of the phosphate chirality at the target site of Mu DNA strand transfer: Evidence for a one-step transesterification mechanism. Cell 66, 129-140.
18. Mombaerts, P., Iacomini, J., Johnson, R.S., Herrup, K., Tonegawa, S. & Papaioannou, V.E. (1992) RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877.
19. Oettinger, M.A., Schatz, D.G., Gorka, C. & Baltimore, D. (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248, 1517-1523.
20. Pergola, F., Zdzienicka, M.Z. & Lieber, M.R. (1993) V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Mol. Cell. Biol. 13, 3464-3471.
21. Peterson, S.R., Kurimasa, A., Oshimura, M., Dynan, W.S., Bradbury, E.M. & Chen, D.J. (1995) Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc. Natl Acad. Sci. USA 92, 3171-3174.
22. Ramsden,D.A. & Gellert, M. (1995) Formation and resolution of double strand break intermediates in V(D)J rearrangement. Genes Dev. 9, 2409-2420.
23. Rathmell, W.K. & Chu, G. (1994) Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. Proc. Natl Acad. Sci. USA 91, 7623-7627.
24. Roth, D.B., Nakajima, P.B., Menetski, J.P., Bosma, M.J. & Gellert, M. (1992a) V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor rearrangement signals. Cell 69, 41-53.
25. Roth, D.B., Menetski, J.P., Nakajima, P.B., Bosma, M.J. & Gellert, M. (1992b) V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70, 983-991.
26. Roth, D.B., Zhu, C. & Gellert, M. (1993) Characterization of broken DNA molecules associated with V(D)J recombination. Proc. Natl Acad. Sci. USA 90, 10788-10792.
27. Sadofsky, M.J., Hesse, J.E. & Gellert, M. (1994) Definition of a core region of RAG-2 that is functional in V(D)J recombination. Nucl. Acids Res. 22, 1805-1809.
28. Sadofsky, M.J., Hesse, J.E., McBlane, J.F. & Gellert, M. (1993) Expression and V(D)J recombination activity of mutated RAG-1 proteins. Nucl. Acids Res. 21, 5644-5650.
29. Schatz, D.G., Oettinger, M.A. & Baltimore, D. (1989) The V(D)J recombination activating gene, RAG-1. Cell 59, 1035-1048.
30. Schlissel, M., Constantinescu, A., Morrow, T., Baxter, M. & Peng, A. (1993) Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAGdependent and cell cycle regulated. Genes Dev. 7, 2520-2532.
31. Schuler, W., Weiler, I.J., Schuler, A., Phillips, R.A., Rosenberg, N., Mak, T.K., Kearney, J.F., Perry, R.P. & Bosma, M.J. (1986) Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46, 963-972.
32. Shinkai, Y., Rathbun, G., Lam, K.-P., Oltz, E.M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A.M. & Alt, F.W. (1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867.
33. Silver, D.P., Spanopolou, E., Mulligan, R.C. & Baltimore, D. (1993) Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination. Proc. Natl Acad. Sci. USA 90, 6100-6104.
34. Smider, V., Rathmell, W.K., Lieber, M.R. & Chu, G. (1994) Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266, 288-291.
35. Taccioli, G.E., Gottlieb, T.M., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehmann, A.R., Alt, F.W., Jackson, S.P. & Jeggo, P.A. (1994) Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265, 1442-5.
36. Taccioli, G.E., Rathbun, G., Oltz, E., Stamato, T., Jeggo, P.A. & Alt, F.W. (1993) Impairment of V(D)J recombination in double-strand repair mutants. Science 260, 207-210.
37. Thompson, C.B. (1995) New insights into V(D)J recombination and its role in the evolution of the immune system. Immunity 3, 531-539.
38. van Gent, D.C., McBlane, J.F., Ramsden, D.A., Sadofsky, M.J., Hesse, J.E. & Gellert, M. (1995) Initiation of V(D)J recombination in a cell-free system. Cell 81, 925-934.
39. van Gent, D.C., Mizuuchi, K. & Gellert, M. (1996) Initiation of V(D)J recombination: similarities to transposition and retroviral integration. Science, 271, 1592-1594.
40. Zhu, C. & Roth, D.B. (1995) Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination. Immunity 2, 101-112.