T cells can induce somatic mutation in B cell receptor-engaged BL2 Burkitt's lymphoma cells independently of CD40-CD40 ligand interactions

Journal of Immunology

Volumn 164, Issue 3, 2000, Pages 1306-1313

  Denépoux, Stéphane ^a,b   Fournier, Nathalie ^a   Péronne, Catherine ^a   Banchereau, Jacques ^a,c   Lebecque, Serge ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^c BAYLOR INSTITUTE FOR IMMUNOLOGY RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; LIGAND;

ARTICLE; BURKITT LYMPHOMA; CELL MEMBRANE; CELL SURFACE; CROSS LINKING; GENE DELETION; GENE INSERTION; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; LIGAND BINDING; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR BINDING; SOMATIC MUTATION; SPECIES DIFFERENTIATION; T LYMPHOCYTE ACTIVATION;

EID: 0343484998     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.3.1306     Document Type: Article

References (55)

1. Reynaud, C. A., C. Garcia, W. R. Hein, and J. C. Weill. 1995. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell 80:115.
2. Weinstein, P. D., A. O. Anderson, and R. G. Mage. 1994. Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms. Immunity 1:647.
3. Wagner, S. D., and M. S. Neuberger. 1996. Somatic hypermutation of immunoglobulin genes. Annu. Rev. Immunol. 14:441.
4. Berek, C., and C. Milstein. 1987. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96:23.
5. Berek, C., A. Berger, and M. Apel. 1991. Maturation of the immune response in germinal centers. Cell 67:1121.
6. Jacob, J., G. Kelsoe, K. Rajewsky, and U. Weiss. 1991. Intraclonal generation of antibody mutants in germinal centres. Nature 354:389.
7. Kuppers, R., M. Zhao, M. L. Hansmann, and K. Rajewsky. 1993. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J. 12:4955.
8. MacLennan, I. C. M., and D. Gray. 1986. Antigen-driven selection of virgin and memory B cells. Immunol. Rev. 91:61.
9. Pascual, V., Y. J. Liu, A. Magalski, O. de Bouleiller, J. Banchereau, and J. D. Capra. 1994. Analysis of somatic mutation in live B cell subsets of human tonsil. J. Exp. Med. 180:329.
10. Kelsoe, G. 1995. The germinal center reaction. Immunol. Today 16:324.
11. Liu, Y. J., and C. Arpin. 1997. Germinal center development. Immunol. Rev. 156:111.
12. MacLennan, I. C. M. 1994. Somatic mutation: from the dark zone to the light. Curr. Biol. 4:70.
13. Tew, J. G., J. Wu, D. Qin, S. Helm, G. F. Burton, and A. K. Szakal. 1997. Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells. Immunol. Rev. 156:39.
14. Pulendran, B., G. Kannourakis, S. Nouri, K. G. C. Smith, and G. J. V. Nossal. 1995. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. Nature 375:331.
15. Goodnow, C. C., J. G. Cyster, S. B. Hartley, S. E. Bell, M. P. Cooke, J. I. Healy, S. Akkaraju, J. C. Rathmell, S. L. Pogue, and K. P. Shokat. 1995. Self-tolerance checkpoints in B lymphocyte development. Adv. Immunol. 59:279.
16. Weigert, M. G., I. M. Cesari, S. J. Yonkovich, and M. Cohn. 1970. Variability in the λ light chain sequences of mouse antibody. Nature 228:1045.
17. Neuberger, M. S., M. R. Ehrenstein, N. Klix, C. J. Jolly, J. Yelamos, C. Rada, and C. Milstein. 1998. Monitoring and interpreting the intrinsic features of somatic hypermutation. Immunol. Rev. 162:107.
18. Wilson, P. C., O. de Bouteiller, Y. J. Liu, K. Potter, J. Banchereau, J. D. Capra, and V. Pascual. 1998. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J. Exp. Med. 187:59.
19. Lebecque, S. G., and P. J. Gearhart. 1990. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is ≈ kb from V(D)J gene. J. Exp. Med. 172:1717.
20. Betz, A. G., C. Rada, R. Pannell, C. Milstein, and M. S. Neuberger. 1993. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc. Natl. Acad. Sci. USA 90:2385.
21. Azuma, T., N. Motoyama, L. E. Fields, and D. Y. Loh. 1993. Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer. Int. Immunol. 5:121.
22. Peters, A., and U. Storb. 1996. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 4:57.
23. Betz, A. G., C. Milstein, A. Gonzalez-Fernandez, R. Pannell, T. Larson, and M. S. Neuberger. 1994. Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for the intron enhancer/matrix attachment region. Cell 77:239.
24. Kim, N., and U. Storb. 1998. The role of DNA repair in somatic hypermutation of immunoglobulin genes. J. Exp. Med. 187:1729.
25. Wiesendanger, M., M. D. Scharff, and W. Edelmann. 1998. Somatic hypermutation, transcription, and DNA mismatch repair. Cell 94:415.
26. Reynaud, C. A., C. R. Mackay, R. G. Muller, and J. C. Weill. 1991. Somatic generation of diversity in a mammalian primary lymphoid organ: the sheep ileal Peyer's patches. Cell 64:995.
27. Grifliths, G. M., C. Berek, M. Kaartinen, and C. Milstein. 1984. Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature 312:271.
28. Miller, C., J. Stedra, G. Kelsoe, and J. Cerny. 1995. Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. J. Exp. Med. 181:1319.
29. Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. 1993. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J. Exp. Med. 178: 1293.
30. van Kooten, C., and J. Banchereau. 1996. CD40-CD40 ligand: a multifunctional receptor-ligand pair. Adv. Immunol. 61:1.
31. 1998. Somatic hypermutation of immunoglobulin genes. Immunol. Rev. 162.
32. Razanajaona, D., S. Denépoux, D. Blanchard, O. de Bouteiller, Y. J. Liu, J. Banchereau, and S. Lebecque. 1997. In vitro triggering of somatic mutation in human naive B cells. J. Immunol. 159:3347.
33. Denépoux, S., D. Razanajaona, D. Blanchard, G. Meffre, J. D. Capra, J. Banchereau, and S. Lebecque. 1997. Induction of somatic mutation in a human B cell line in vitro. Immunity 6:35.
34. Cohen, J. H., J. P. Revillard, J. P. Magaud, G. Lenoir, M. Vuillaume, A. M. Manel, C. Vincent, and P. A. Bryon. 1987. B-cell maturation stages of Burkitt's lymphoma cell lines according to Epstein-Barr virus status and type of chromosome translocation. J. Natl. Cancer Inst. 78:235.
35. van Kooten, C., C. Gaillard, J. P. Galizzi, P. Hermann, F. Fossiez, J. Banchereau, and D. Blanchard. 1994. B cells regulate expression of CD40-ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40. Eur. J. Immunol. 24:787.
36. Parronchi, P., D. Macchia, M. P. Piccini, P. Biswas, C. Simonelli, E. Maggi, M. Ricci, A. A. Ansari, and S. Romagnani. 1991. Allergen-and bacterial antigen-specific T-cell clones established from atopic donors show a different prolile of cytokine production. Proc. Natl. Acad. Sci. USA 88:4538.
37. Servet-Delprat, C., J. M. Bridon, D. Blanchard, J. Banchereau, and F. Brière. 1995. CD40-activated human naive surface 1gD+ B cells produce IgG2 in response to activated T cell supernatant. Immunology 85:435.
38. Liu, Y.-J., C. Arpin, O. de Bouteiller, C. Guret, J. Banchereau, H. Martinez-Valdez, and S. Lebecque. 1996. Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development. Semin. Immunol. 8:169.
39. Defrance, T., B. Vanbervliet, F. Brière, I. Durand, F. Rousset, and J. Banchereau. 1992. Interleukin 10 and transforming growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J. Exp. Med. 175:671.
40. Jabara, H. H., S. M. Fu, R. S. Geha, and D. Vercelli. 1990. CD40 and IgE: synergism between anli-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J. Exp. Med. 172: 1861.
41. Renshaw, B. R., W. C. Fanslow III, R. J. Armitage, K. A. Campbell, D. Liggitt, B. Wright, B. L. Davison, and C. R. Maliszewski. 1994. Humoral immune responses in CD40 ligand-deficient mice. J. Exp. Med. 180:1889.
42. Xu, J., T. M. Foy, J. D. Laman, E. A. Elliott, J. J. Dunn, T. J. Waldschmidt, J. Elsemore, R. J. Noelle, and R. A. Flavell. 1994. Mice deficient for the CD40 ligand. Immunity 1:423.
43. Kawabe, T., T. Naka, K. Yoshida, T. Tanaka, H. Fujiwara, S. Suematsu, N. Yoshida, T. Kishimoto, and H. Kikutani. 1994. The immune response in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1:167.
44. Casligli, E., F. W. Alt, L. Davidson, A. Bottaro, E. Mizoguchi, A. K. Bhan, and R. S. Geha. 1994. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc. Natl. Acad. Sci. USA 91:12135.
45. Brière, F., and J. Banchereau. 1996. Polyclonal activation of human mature B lymphocytes. In Handbook of Experimental Immunology, 5th Ed., Vol. 4. D. Weir, C. Blackwell, and L. L. Herzenberg, eds. Blackwell Scientific, Oxford, p. 224.1.
46. Razanajaona, D., C. van Kooten, S. Lebecque, J. M. Bridon, S. Ho, S. Smith, R. Callard, J. Banchereau, and F. Brière. 1996. Somatic mutations in human Ig variable genes correlate with a partially functional CD40-ligand in the X-linked hyper-IgM syndrome. J. Immunol. 157:1492.
47. Arpin, C., J. Déchanet, C. van Kooten, P. Merville, G. Grouard, F. Brière, J. Banchereau, and Y. J. Liu. 1995. Generation of memory B cells and plasma cells in vitro. Science 268:720.
48. Casson, L. P., and T. Manser. 1995. Evaluation of loss and change of specificity resulting from random mutagenesis of an antibody VH region. J. Immunol. 155: 5647.
49. van Kooten, C., and J. Banchereau. 1997. Functional role of CD40 and its ligand. Int. Arch. Allergy Immunol. 113:393.
50. Lipsky, P. E., J. F. Attrep, A. C. Grammer, M. J. McIlraith, and Y. Nishioka. 1997. Analysis of CD40-CD40 ligand interactions in the regulation of human B cell functions. Ann. NY Acad. Sci. 815:372.
51. Liu, Y. J., O. de Bouteiller, and I. Fugier-Vivier. 1997. Mechanisms of selection and differentiation in germinal center. Curr. Opin. Immunol. 9:256.
52. Chu, Y. W., E. Marin, R. Fuleihan, N. Ramesh, F. S. Rosen, R. S. Geha, and R. A. Insel. 1995. Somatic mutation of human immunoglobulin V genes in the X-linked hyperIgM syndrome. J. Clin. Invest. 95:1389.
53. Choe, J., H. S. Kim, X. Zhang, R. J. Armitage, and Y. S. Choi. 1996. Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells: anti-Ig down-regulates Fas expression of CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis. J. Immunol. 157: 1006.
54. + B cell line in vitro: definition of the requirements and modalities of hypermutation. J. Immunol. 162:3437.
55. Sale, J. E., and M. S. Neuberger. 1998. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity 9:859.