Hex: A homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors

Development

Volumn 125, Issue 1, 1998, Pages 85-94

  Thomas, P Q ^a   Brown, A ^b   Beddington, R S P ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Angiogenesis; Axis formation; Endoderm; Endothelial cell; Gastrulation; Hex; Mouse; Vasculogenesis

Indexed keywords

ANGIOGENESIS; ANIMAL CELL; ANTERIOR POSTERIOR AXIS; ARTICLE; BLASTOCYST; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; ENDOCARDIUM; ENDODERM; ENDOTHELIUM CELL; GASTRULATION; GENE EXPRESSION; HOMEOBOX; IN SITU HYBRIDIZATION; INTESTINE; MESODERM; MOUSE; NIDATION; NONHUMAN; PRIMITIVE STREAK; PRIORITY JOURNAL; STEM CELL; THYROID GLAND; VISCERA; YOLK SAC;

ANIMALS; BODY PATTERNING; CARBOCYANINES; CELL DIFFERENTIATION; DIGESTIVE SYSTEM; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; ENDODERM; ENDOTHELIUM, VASCULAR; GASTRULA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; HISTOCYTOCHEMISTRY; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; STEM CELLS; TRANSCRIPTION FACTORS;

ANIMALIA; MAMMALIA;

EID: 0031984524     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. -/- mutants due to a defective anterior neurectoderm specification during gastrulation. Development 121, 3279-3290.
2. Ang, S. L., Wierda, A., Wong, D., Stevens, K. A., Cascio, S., Rossant, J. and Zaret, K. (1993). The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 119, 1301-15.
3. Ang, S. L. and Rossant, J. (1994). HNF-3 beta is essential for node and notochord formation in mouse development. Cell 78, 561-74.
4. Ang, S.-L., Conlon, R. A., Jin, O. and Rossant, J. (1994). Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development 120, 2979-2989.
5. Beddington, R. S. P. (1987). Isolation, culture and manipulation of post-implantation mouse embryos. In Mammalian Development: A Practical Approach (ed. M. Monk), pp. 43-69. Oxford: IRL Press.
6. Bedford, F. K., Ashworth, A., Enver, T. and Wiedemann, L. M. (1993). HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res. 21, 1245-1249.
7. Bouwmeester, T., Kim, S-H., Sasai, Y., Lu, B. and De Robertis, E. M. (1996). Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382, 595-601.
8. Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., Declercq, C., Pawling, J., Moons, L., Collen, D., Risau, W. and Nagy, A. (1996). Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439
9. Coffin, J. D. and Poole, T. J. (1988). Embryonic vascular development: Immunohistochemical identification of the origin and subsequent morphogenesis of the major vessel primordia in quail embryos. Development 102, 735-748
10. Coffin, J. D., Harrison, J., Schwartz, S. and Heimark, R. (1991). Angioblast differentiation and morphogenesis of the vascular endothelium of the mouse embryo. Dev. Biol. 148, 51-62.
11. Compton, M. R., Bartlett, T. J., MacGregor, A. D., Manfioletti, G., Buratti, E., Giancotti, V. and Goodwin, G. H. (1992). Identification of a novel homeobox gene expressed in haematopoietic cells. Nucleic Acids Res. 20, 5661-5667
12. Conlon, F. L., Barth, K. S. and Robertson, E. J. (1991). A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration. Development 111, 969-981.
13. Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O'Shea, K. S., Powell-Braxton, Lilian, K. J. and Moore M. W. (1996). Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439-442
14. Fishman, M. C. and Chien, K. R. (1997). Fashioning the vertebrate heart: earliest embryonic decisions. Development 124, 2099-2117
15. Fong, G-H., Rossant, J., Gertsenstein, M. and Breitman, M. L. (1995). Role of the Fit-1 receptor tyrosine kinase in regulating the assembly of the vascular endothelium. Nature 376, 66-70
16. Gardner, R. L. (1978). Production of chimeras by injecting cells or tissue into the blastocyst. In Methods in Mammalian Reproduction (ed. J. C. Daniel), pp. 137-165. New York: Academic Press.
17. Gardner, R. L. (1983). Origin and differentiation of extraembryonic tissues in the mouse. Int. Rev. Exp. Pathol 24, 63-133.
18. Gardner, R. L. (1997). The early blastocyst is bilaterally symmetrical and its axis of symmetry is aligned with the animal-vegetal axis of the zygote in the mouse. Development 124, 289-301
19. Gardner, R. L. and Rossant, J. (1979). Investigation of the fate of 4.5 day post coitum mouse inner cell mass cells by blastocyst injection. J. Embryol. Exp. Morph. 52, 141-152.
20. Gardner, R. L., Meredith, M. R. and Altman, D. G. (1992). Is the anterior-posterior axis of the fetus specified before implantation in the mouse? J. Exp. Zool. 264, 437-443.
21. Harrison, S. M., Dunwoodie, S. L., Arkell, R. M., Lehrach, H. and Beddington, R. S. P. (1995). Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue components of the gastrulating mouse embryo. Development 121, 2479-2489.
22. Hemmati-Brivanlou, A, Stewart, R.M. and Harland, R.M. (1990). Region-specific neural induction of an engrailed protein by anterior notochord in Xenopus. Science 250, 800-802
23. Hermesz, E., Mackem, S. and Mahon, K. A. (1996). Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Development 122, 41-52.
24. Hogan, B., Beddington, R., Costantini, F. and Lacy, E. (1994). Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory,
25. Hromas, R., Radich, J. and Collins, S. (1993). PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells. Biochem. Biophys. Res. Comm. 195, 976-983
26. Joterau, F. and LeDouarin, N. (1978). The developmental relationship between osteocytes and osteoclasts: A study using the quail-chick nuclear marker in endochondral ossification. Dev. Biol. 63, 253-265
27. Kaufman, M. H. (1992). The Atlas of Mouse Development. London: Academic Press.
28. Kessler, D. S. and Melton, D. A. (1994). Vertebrate embryonic induction: mesodermal and neural patterning. Science 266, 596-604.
29. Lawson, K. A., Pedersen, R. A. and van der Geer, S. (1987). Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse. Development 101, 627-652.
30. Lawson, K. A., Meneses, J. J. and Pedersen, R. A. (1991). Clonal analysis of epiblast during germ layer formation in the mouse embryo. Development 113, 891-911.
31. Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I. and Harvey, R. P. (1993). Nkx-2.5: a novel murine homeobox gene expressed in the early heart progenitor cells and their myogenic descendants. Development 119, 419-431.
32. Manfioletti, G., Gattei, V., Buratti, E., Rustighi, A., De Iuliis, A., Aldinucci, D., Goodwin, G. H. and Pinto, A. (1995). Differential expression of a novel proline-rich homeobox gene (Prh) in human hematolymphopoietic cells. Blood 85, 1237-1245
33. Miller, J. R. and Moon, R. T. (1996). Signal transduction through β-catenin and specification of cell fate during embryogenesis. Genes Dev., 10, 2527-2539
34. Pöpperl, H., Schmidt, C. Wilson, V., Hume, C., Dodd, J., Krumlauf, R. and Beddington, R. S. P. (1997). Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neurectoderm. Development 124, 2997-3005.
35. Risau, W. (1997). Mechanisms of angiogenesis. Nature 386, 671-674.
36. Rosenquist, T. A. and Martin, G. R. (1995). Visceral endoderm-1 (VE-1): an antigen marker that distinguishes anterior from posterior embryonic visceral endoderm in the early post-implantation mouse embryo. Mech. Dev. 49, 117-121.
37. Rothstein, J. L., Johnson, D., DeLoia, J. A., Skowronski, J., Solter, D. and Knowles, B. (1992). Gene expression during preimplantation mouse development. Genes. Dev. 6, 1190-1201.
38. Sabin, F. (1920). Studies on the origin of blood vessels and of red blood corpuscles as seen in the living blastoderm of chicks during the second day of incubation. Contrib. Embryol. Carnegie Inst. Wash., 214-262
39. Saha, M. S. and Grainger, R. M. (1992). A labile period in the determination of the anterior-posterior axis during early neural development in Xenopus. Neuron, 8, 1003-1014
40. Sasaki, H. and Hogan, B. L. M. (1993). Differential expression of multiple forkhead genes during gastrulation and axial pattern formation in the mouse embryo. Development 118, 47-59.
41. Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg-Buchholz, K., Fujiwara, Y., Gendron-Maguire, M., Gridley, T., Wolburg, H., Risau, W. and Qin, Y. (1995). Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376, 70-74
42. Scholer, H., Ruppert, S., Suzuki, N., Chowdhury, K. and Gruss, P. (1990). New type of POU domain in germ line-specific protein Oct-4. Nature 344, 435-439.
43. Serbedzija, G. N., Bronner-Fraser, M. and Fraser, S. E. (1989). A vital dye analysis of the timing and pathways of avian trunk neural crest cell migration. Development 106, 809-816.
44. Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X-F., Breitman, M. L. and Schuh, A. C. (1995). Failure of blood-island formation and vasculogenesis in flk-1-deficient mice. Nature 376, 62-66.
45. Shalaby, F., Ho, J., Stanford, W. L., Fischer, K-D., Schuh, A. C., Schwartz, L., Bernstein, A. and Rossant, J. (1997). A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis Cell 89, 981-990
46. Sharpe, C.R. and Gurdon, J.B. (1990). The induction of anterior and posterior neural genes in Xenopus laevis. Development 109, 765-774
47. Shawlot, W. and Behringer, R. (1995). Requirement for Lim-1 in head organizer function. Nature 374, 425-430.
48. Sive, H. L. (1993). The frog prince-ss: A molecular formula for dorsoventral patterning in Xenopus. Genes Dev. 7, 1-12.
49. Snow, M. H. L. (1977). Gastrulation in the mouse: growth and regionalization of the epiblast. J. Embryol. exp. Morph. 42, 293-303.
50. Smith, L. J. (1985). Embryonic axis orientation in the mouse and its correlation with blastocyst relationships to the uterus. II. Relationships from 4.5 to 9.5 days. J. Embryol. exp. Morph. 89, 15-35.
51. Smith, L. J. (1980). Embryonic axis orientation in the mouse and its correlation with blastocysts' relationships to the uterus. Part I. Relationship between 82hours and 41/2 days. J. Embryol. exp. Morphol. 55, 257-277.
52. Stewart, P. and Wiley, M. (1981). Developing nervous tissue induces formation of blood-brain characteristics in invading endothelial cells: A study using quail-chick transplantation chimeras. Dev. Biol. 84, 183-192
53. Sugi, Y. and Markwald, R. R. (1996). Formation and early morphogenesis of endocardial endothelial precursor cells and the role of endoderm. Dev. Biol. 175, 66-83
54. Tam, P. P. L. and Beddington, R. S. P. (1992). Establishment and organization of germ layers in the gastrulating mouse embryo. In Postimplantation Development in the Mouse. Ciba Foundation Symposium 165, 27-41. Chichester: John Wiley and Sons.
55. Thomas, P. Q. and Beddington, R. S. P. (1996). Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo. Curr. Biol. 6, 1487-1496.
56. Thomas, P. Q., Brickman, J., Pöpperl, H., Krumlauf, R. and Beddington, R. S. P. (1997). Axis duplication and anterior identity in the mouse embryo. In, Symposia of Quantitative Biology, Cold Spring Harbor Press, in press
57. Varlet, I., Collignon, J. and Robertson, E. J. (1997). nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development 124, 1033-1044.
58. Wagner, R. C. (1980). Endothelial cell embryology and growth. Adv. Microcirc. 9, 45-75.
59. Weinstein, D. C., Ruiz, i. A. A., Chen, W. S., Hoodless, P., Prezioso, V. R., Jessell, T. M. and Darnell, J. J. (1994). The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell 78, 575-88.
60. Wilkinson, D. G. (1992) Whole mount in situ hybridisation of vertebrate embryos. In In situ Hybridisation. Edited by Wilkinson D. Oxford:IRL Press; 75-83.
61. Wilson, V. and R. S. P. Beddington (1996). Cell fate and morphogenetic movement in the late mouse primitive streak. Mech. Dev. 55, 79-89.
62. Yamaguchi, T. P., Dumont, D. J., Conlon, R. A., Breitman, M. L. and Rossant, J. (1993). flk-1, an flt-related receptor tyrosine kinase in an early marker for endothelial cell precursors. Development 118, 489-498.
63. Yatskievych, T.A., Ladd, A.N. and Antin, P.B. (1997). Induction of cardiac myogenesis in avian pregastrula epiblast: the role of the hypoblast and activin. Development 124, 2561-2580.