Conversion of a gene-specific repressor to a regional silencer

Genes and Development

Volumn 15, Issue 8, 2001, Pages 955-967

  Rusche L N ^a   Rine, J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chromatin immunoprecipitation; Epigenetic; Histone deacetylase; Meiosis; Position effect

Indexed keywords

HISTONE; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; CHROMATIN; DNA SEQUENCE; ENZYME ACTIVITY; GENE MUTATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HETEROCHROMATIN; IMMUNOPRECIPITATION; MEIOSIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SILENCER GENE; YEAST;

CELL DIVISION; DNA-BINDING PROTEINS; EPITOPES; FUNGAL PROTEINS; GENE SILENCING; GENES, DOMINANT; GENOTYPE; HETEROCHROMATIN; HISTONE DEACETYLASES; HISTONES; MODELS, GENETIC; MUTATION; NUCLEAR PROTEINS; ORIGIN RECOGNITION COMPLEX; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; RNA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; TRANS-ACTIVATORS;

SACCHAROMYCES CEREVISIAE;

EID: 0035871393     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.873601     Document Type: Article

References (42)

1. NuRD and SIN3 histone deacetylase complexes in development
2. Histone deacetylases: Transcriptional repression with SINers and NuRDs
3. The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing
4. The yeast HML I silencer defines a heterochromatin domain boundary by directional establishment of silencing
5. The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
6. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
7. SUM1-1, a dominant suppressor of SIR mutations in Saccharomyces cerevisiae, increases transcriptional silencing at telomeres and HM mating-type loci and decreases chromosome stability
8. Exploring the metabolic and genetic control of gene expression on a genomic scale
9. The boundaries of the silenced HMR domain in Saccharomyces cerevisiae
10. Roles for the Saccharomyces cerevisiae SDS3, CBK1 and HYM1 genes in transcriptional repression by SIN3
11. The organized chromatin domain of the repressed yeast a cell-specific gene STE6 contains two molecules of the corepressor Tup1p per nucleosome
12. Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4
13. Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae
14. The origin recognition complex SIR1 the S phase requirement for silencing
15. A region of the Sir1 protein dedicated to recognition of a silencer and required for interaction with the Orc1 protein in Saccharomyces cerevisiae
16. Localization of Sir2p: The nucleolus as a compartment for silent information regulators
17. Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast
18. Spreading of transcriptional repressor SIR3 from telomeric heterochromatin
19. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
20. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters
21. Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo
22. SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae
23. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
24. SUM1-1: A suppressor of silencing defects in Saccharomyces cerevisiae
25. Genetic analysis of the role of Pol II holoenzyme components in repression by the Cyc8-Tup1 corepressor in yeast
26. The sum1-1 mutation affects silent mating-type gene transcription in Saccharomyces cerevisiae
27. The origin recognition complex in silencing, cell cycle progression, and DNA replication
28. A synthetic silencer mediates SIR-dependent functions in Saccharomyces cerevisiae
29. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
30. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes
31. One-step gene disruption in yeast
32. Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3
33. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier
34. A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae
35. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
36. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
37. Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing
38. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae
39. Ssn6-Tup1 interacts with class I histone deacetylases required for repression
40. Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae
41. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex