Combinatorial peptide libraries and biometric score matrices permit the quantitative analysis of specific and degenerate interactions between clonotypic TCR and MHC peptide ligands

Journal of Immunology

Volumn 167, Issue 4, 2001, Pages 2130-2141

  Zhao, Y ^a   Gran, B ^a   Pinilla, C ^a   Markovic Plese, S ^a   Hemmer, B ^a   Tzou, A ^a   Whitney, L W ^a   Biddison, W E ^a   Martin, R ^a   Simon, R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE DISEASE; HUMAN; HUMAN CELL; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE;

EID: 0035881251     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.4.2130     Document Type: Article

References (59)

1. Assembly, transport, and function of MHC class II molecules
2. Structure of peptides associated with class I and class Il MHC molecules
3. The three-dimensional structure of peptide-MHC complexes
4. Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules
5. Identification of an HLA-DQ2 peptide binding motif and HLA-DPw3-bound self-peptide by pool sequencing
6. Interactions between immunogenetic peptides and MHC proteins
7. Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays
8. Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning
9. Promiscuous and allele-specific anchors in HLA-DR binding peptides
10. MHC ligands and peptide motifs: First listing
11. Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis
12. Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices
13. New methods to predict MHC-binding sequences within protein antigens
14. Multiple regression analysis suggests motifs for class II MHC binding
15. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains
16. Several common HLA-DR types share largely overlapping peptide binding repertoires
17. Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network
18. Two complementary methods for predicting peptides binding major histocompatibility complex molecules
19. Neural network-based prediction of candidate T-cell epitopes
20. Application of an artificial neural network to predict specific class I MHC binding peptide sequences
21. An empirical method for the prediction of T-cell epitopes
22. Prediction of HIV peptide epitopes by a novel algorithm
23. Structural basis for T cell recognition of altered peptide ligands: A single T cell receptor can productively recognize a large continuum of related ligands
24. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
25. Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology
26. Exploring immunological specificity using synthetic peptide combinatorial libraries
27. Antigen arrays in T cell immunology
28. Specificity and degeneracy of minor histocompatibility antigen-specific MHC-restricted CTL
29. Determination oft cell epitopes with random peptide libraries
30. Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone
31. + T cells and induce T cell responses to native peptide ligands
32. Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency
33. + cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106
34. Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease
35. Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands for autoreactive T cells
36. Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99)
37. General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids
38. 12) sequences
39. Analysis of a sequenced cDNA library from multiple sclerosis lesions
40. Immunopathology of multiple sclerosis: Report on an international meeting held at the Institute of Neurology of the University of Vienna
41. Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays
42. The I.M.A.G.E. Consortium: An integrated molecular analysis of genomes and their expression
43. Development of a prostate cDNA microarray and statistical gene expression analysis package
44. Ratio-based decisions and the quantitative analysis of cDNA microarray images
45. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone
46. Measuring the accuracy of diagnostic systems
47. Titins: Giant proteins in charge of muscle ultrastructure and elasticity
48. In thymic selection, peptide diversity gives and takes away
49. Probing degeneracy in T-cell recognition using combinatorial peptide libraries
50. Molecular mimicry and multiple sclerosis: Degenerate T-cell recognition and the induction of autoimmunity
51. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
52. An α/β T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex
53. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex
54. Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
55. Negative selection of lymphocytes
56. Preferential expansion of autoreactive T lymphocytes from the memory T-cell pool by IL-7
57. Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells
58. Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (BI*0401) subjects is associated with a restricted T cell receptor repertoire
59. Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor-reactive cytolytic T lymphocytes