Determination of T cell epitopes with random peptide libraries

Journal of Immunological Methods

Volumn 192, Issue 1-2, 1996, Pages 149-155

  Gundlach, Björn R ^a   Wiesmüller, Karl Heinz ^b   Junt, Tobias ^a   Kienle, Stefan ^c   Jung, Günther ^c   Walden, Peter ^a,d  

^a MAX PLANCK INST FÜR BIOLOGIE   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d HUMBOLDT UNIVERSITY   (Germany)

Author keywords

cytotoxic T lymphocyte; epitope; peptide; peptide library; specificity; T cell

Indexed keywords

EPITOPE; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CYTOTOXIC T LYMPHOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALIA;

EID: 0343150927     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-1759(96)00040-3     Document Type: Article

References (23)

1. Barber, L.D. and Parham, P. (1993) Peptide binding to major histocompatibility molecules. Annu. Rev. Cell Biol. 9, 163.
2. Borges, E., Wiesmüller, K.-H., Jung, G. and Walden, P. (1994) Efficacy of synthetic vaccines in induction of cytotoxic T lymphocytes. J. Immunol. Methods 173, 253.
3. Falk, K., Rötzschke, O., Stevanović, S., Jung, G. and Rammensee, H.-G. (1991) Allele specific motifs revealed by sequencing of self peptides eluted from MHC molecules. Nature 315, 290.
4. Falk, K., Rötzschke, O., Stevanović, S., Gnau, V., Sparbier, K., Jung, G., Rammensee, H.-G. and Walden, P. (1994) Analysis of a naturally occurring HLA class I-restricted viral epitope. Immunology 82, 337.
5. Feiertag, S., Gnau, V., Udaka, K., Walden, P., Jung, G. and Wiesmüller, K.-H. (1994) Coupling methods for X-positions in octapeptide mixtures applied in competition experiments with killer cells. In: R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis. Mayflower Worldwide, London, p. 501.
6. b. Science 257, 919.
7. Hill, A.V.S., Elvin, J., Willis, A.C., Aidoo, M., Allsopp, C.E.M., Gotch, F.M., Ming Gao, X., Takiguchi, M., Greenwood, B.M., Townsend, A.R.M., McMichael, A.J. and Whittle, H.C. (1992) Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360, 434.
8. Hunt, D.F., Henderson, R.A., Shabnowitz, J., Sakaguchi, K., Michel, H., Selilir, N., Cox, A., Appella, E. and Engelhard, V.H. (1992) Characterization of peptides bound to the class I MHC molecule HLA A2.1 by mass spectrometry. Science 255, 1261.
9. Jung, G. and Beck-Sickinger, A.G. (1992) Multiple peptide synthesis methods and their applications. Angew. Chem. Int. Ed. Engl. 31, 367.
10. Klein, J., Figueroa, F. and Davis, C.S. (1983) H-2 haplotypes, genes and antigens: Second listing. Immunogenetics 17, 553.
11. Köhler, G., Fischer-Lindahl, K. and Heusser, C. (1981) In: C. Steinberg and I. Lefkovitz (Eds.), The Immune System. Karger, Basel, p. 202.
12. Livingstone, A.M. and Fathman, C.G. (1987) The structure of T cell epitopes. Annu. Rev. Immunol. 5, 477.
13. Ljunggren, H.-G. and Kärre, K. (1985) Host resistance directed selectively against H-2-deficient lymphoma variants. J. Exp. Med. 162, 1745.
14. Ljunggren, H.-G., Stam, N.J., Öhlen, C., Neefjes, J.J., Höglund, P., Heemels, M.T., Bastin, J., Schumacher, T.N.M., Townsend, A., Kärre, K. and Ploegh, H.L. (1990) Empty MHC class I molecules come out in the cold. Nature 346, 476.
15. Matsumura, M., Fremont, D.H., Peterson, P.A. and Wilson, I.A. (1992) Emerging principles for the recognition of peptide antigens by MHC class I molecules. Science 257, 927.
16. Metzger, J.W., Kempter, C., Wiesmüller, K.-H. and Jung, G. (1994) Electrosppray mass spectrometry and tandem mass spectrometry of multicomponent peptide mixtures: Determination of composition and purity. Anal. Biochem. 219, 261.
17. Rammensee, H.-G., Friede, T. and Stevanović, S. (1995) MHC ligands and peptide motifs: First listing. Immunogenetics 41, 178.
18. Stevanović, S. and Jung, G. (1993) Multiple sequence analysis: Pool sequencing of synthetic and natural peptide libraries. Anal. Biochem. 212, 212.
19. + cytotoxic T lymphocytes in association with a class I MHC protein. Cell 69, 989.
20. b. J. Biol. Chem. 270, 24130.
21. Udaka, K., Wiesmüller, K.-H., Kienle, S., Jung, G. and Walden. P. (1995b) Decrypting the structure of MHC I-restricted CTL epitopes with complex peptide libraries. J. Exp. Med. 181, 2097.
22. b molecule. Nature 348, 213.
23. b molecule containing a single viral peptide: Implications for peptide binding and T cell receptor recognition. Proc. Natl. Acad. Sci. USA 89, 8403.