Specificity and degeneracy of minor histocompatibility antigen-specific MHC-restricted CTL

Journal of Immunology

Volumn 156, Issue 10, 1996, Pages 3645-3651

  Gundlach, Björn R ^a   Wiesmüller, Karl Heinz ^b   Junt, Tobias ^a   Kienle, Stefan ^b   Jung, Günther ^b   Walden, Peter ^a,c  

^a MAX PLANCK INST FÜR BIOLOGIE   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; CONFORMATIONAL TRANSITION; CYTOTOXIC T LYMPHOCYTE; LYMPHOCYTE CLONE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CLONE CELLS; CONSENSUS SEQUENCE; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES; H-2 ANTIGENS; MICE; MINOR HISTOCOMPATIBILITY ANTIGENS; MOLECULAR SEQUENCE DATA; PEPTIDES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0029967743     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Rammensee, H -G , T. Friede, and S. Stevanovic. 1995 MHC ligands and peptide motifs: first listing. Immunogenetics 41:178.
2. Falk, K., O. Rötzschke, S Stevanovic, G. Jung, and H.-G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351:290.
3. b. Science 257 919.
4. Matsumura, M., D H. Fremont, P. A. Peterson, and I. A Wilson. 1992. Emerging principles for the recognition of peptide antigens by MHC class I molecules. Science 257:927
5. Ajitkumar, P., S. S. Geier, K. V Kesari, F. Borriello, M Nakagawa, J. A. Bluestone, M. A Saper, D C Wiley, and S G. Nathenson. 1988 Evidence that multiple residues on both the α-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor. Cell 54:47
6. + T cells. Immunol. Rev. 135:157.
7. + T cells in the thymus. Cell 73:1041.
8. + T cells induced by major histocompatibility complex binding peptides in fetal thymic organ cultures. J. Exp. Med 177, 1469.
9. Rötzschke, O., K Falk, S. Stevanovic, G Jung, and H.-G. Rammensee. 1991. On the nature of peptides involved in T cell alloreactivity. J. Exp. Med. 174:1059
10. + cytotoxic T lymphocytes in association with a class I MHC protein. Cell 69:989.
11. Ohno, S. 1991. Many peptide fragments of alien antigens are homologous with host proteins, thus canalizing T-cell responses. Proc. Natl. Acad Sci. USA 88: 3065.
12. Germain, R. N., and D. H. Margulies 1993. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Immunol. 11:403
13. b. J. Biol. Chem. 270:24130.
14. Scott, D. M , I E Ehrmann, P. S. Ellis, C E Bishop, A. I. Agulnik, E. Simpson, and M. J Mitchell. 1995. Identification of a mouse male-specific transplantation antigen, H-Y. Nature 376:695.
15. Graff, R. J., V. Hauptfeld, K. Riordan, and M. Kurtz. 1994. Continued mapping of chromosome 2 genes. Immunogenetics 40:21
16. Roopenian, D. C., A. P. Davis, O. J. Christianson, and L. E. Mobraaten 1993 The functional basis of minor histocompatibility loci. J. Immunol. 151:4595
17. Ljunggren, H.-G , N. J Stam, C Öhlen, J. J Neefjes, P Hoglund, M. T. Heemels, JJ. Bastin, T N. M Schumacher, A. Townsend, K. Kärre, and H. L. Ploegh 1990. Empty MHC class I molecules come out in the cold. Nature 346:476.
18. Klein, J., F. Figueroa, and C. S. David. 1983. H-2 haplotypes, genes and antigens: second listing Immunogenetics 17:553.
19. Borges, E., K.-H. Wiesmüller, G. Jung, and P. Walden. 1994. Efficacy of synthetic vaccines in the induction of cytotoxic T lymphocytes: comparison of the costimulating support provided by helper T cells and lipoamino acid. J. Immunol. Methods 173:253.
20. Jung, G., and A. G. Beck-Sickinger. 1992. Multiple peptide synthesis methods and their applications Angew Chem Int Ed. Engl. 31:367.
21. Udaka, K , K.-H. Wiesmüller, S. Kienle, G. Jung, and P. Walden. 1995. Decrypting the structure of MHC-I-restricted CTL epitopes with complex peptide libraries. J. Exp. Med 181:2097.
22. Stevanovic, S., and G. Jung. 1993. Multiple sequence analysis pool sequencing of synthetic and natural peptide libraries. Anal. Biochem 212.212.
23. Metzger, J. W., C. Kempter, K.-H. Wiesmüller, and G Jung. 1994. Electrospray mass spectrometry and tandem mass spectrometry of multicomponent peptide mixtures: determination of composition and purity Anal. Biochem. 219:261
24. 2m, H-3 region. J. Immunol. 135: 2847.
25. Kurtz, M E., D Martin-Morgan, and R. J Graff 1987. Recognition of the β-2 microglobulin-B molecule by a CTL clone. J. Immunol 138:87
26. Roopenian, D. C., and A. P. Davis 1989. Responses against antigens encoded by the H-3 histocompatiblility locus, antigens stimulating class I MHC and class II MHC-restricted T cells are encoded by separate genes. Immunogenetics 30:335.
27. Gundlach, B. R., K.-H. Wiesmuller, T Junt, S Kienle, G. Jung, and P Walden 1996. Determination of T cell epitopes with random peptide libraries. J. Immunol. Methods. In press.
28. Feiertag, S., V. Gnau, K. Udaka, P. Walden, G. Jung, and K.-H. Wiesmuller. 1994 Coupling methods for X-positions in octapeptide mixtures applied in competition experiments with killer cells. In Innovation and Perspective in Solid Phase Synthesis. R. Epton, ed. Mayflower Worldwide Ltd., Birmingham, U.K pp. 501-504.
29. Rammensee, H.-G., P. J Robinson, A. Crisanti, and M. J. Bevan 1986. Restricted recognition of β2-microglobulin by cytotoxic T lymphocytes. Nature 319.502.
30. Gates, F. T., III, J. E. Coligan, and T. J. Kindt. 1981. Complete amino acid sequence of murine β2-microglobulin: structural evidence for strain-related polymorphism. Proc. Natl. Acad. Sci. USA 78.554.
31. Udaka, K., K.-H. Wiesmüller, S. Kienle, G. Jung, and P. Walden. 1996. Self MHC-restricted peptides recognized by an alloreactive T lymphocyte clone. J. Immunol. In press
32. Zadeh, L A. 1965 Fuzzy sets. Inf Control 6:338.
33. Marusic-Galesic, S., K. Sparbier, N. Knezevic, and P. Walden. 1996. Altered allogeneic response in neonatally and-MHC class I-treated mice Scand. J. Immunol. In press
34. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein Cell 80:695
35. Niedermann, G., S. Butz, H -G. Ihlenfeldt, R Grimm, M Lucchiari, H. Hoschützky, G. Jung, B. Maier, and K. Eichmann. 1995. Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules Immunity 2:289.
36. Uebel, S., T. H Meyer, W Kraas, S Kienle, G. Jung, K.-H Wiesmüller, and R. Tampé. 1995. Requirements for peptide binding to the human transporter associated with Ag processing revealed by peptide scans and complex peptide libraries. J. Biol. Chem. 270:18512.
37. Schirmbeck, R., and J. Reimann. 1994. Peptide transporter-independent, stress protein-mediated endosomal processing of endogenous protein Ags for major histocompatibility complex class I presentation. Eur. J. Immunol. 24:1478.