Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency

Journal of Immunology

Volumn 164, Issue 2, 2000, Pages 861-871

  Hemmer, Bernhard ^a,b   Pinilla, Clemencia ^c,d   Gran, Bruno ^b   Vergelli, Marco ^b,e   Ling, Nick ^f   Conlon, Paul ^f   McFarland, Henry F ^b   Houghten, Richard ^c,d   Martin, Roland ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

^d Mixture Sciences Inc   (United States)

^e UNIVERSITY OF FLORENCE   (Italy)

^f NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; MYELIN BASIC PROTEIN; PEPTIDE DERIVATIVE; T LYMPHOCYTE RECEPTOR;

AMINO ACID SUBSTITUTION; ANTIGEN RECOGNITION; ARTICLE; HELPER CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0034650437     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.2.861     Document Type: Article

References (55)

1. Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T cell recognition of antigen. Nature 380:495.
2. Hemmer, B., M. Vergelli, C. Pinilla, R. Houghten, and R. Martin. 1998. Probing degeneracy in T cell antigen recognition by combinatorial peptide libraries. Immunol. Today 19:163.
3. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 84:521.
4. Kirberg, J., A. Berns, and H. von Boehmer. 1997. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J. Exp. Med. 186:1269.
5. b. J. Biol. Chem. 270:24130.
6. Fleckenstein, B., H. Kalbacher, C. P. Muller, D. Stoll, T. Halder, G. Jung, and K. H. Wiesmüller. 1996. New ligands binding to the human leukocyte antigen class II molecule DRB1*0101 based on the activity pattern of an undecapeptide library. Eur. J. Biochem. 240:71.
7. Gundlach, B. R., K.-H. Wiesmüller, T. Junt, S. Kienle, G. Jung, and P. Walden. 1996. Specificity and degeneracy of minor histocompatibility antigen-specific MHC-restricted CTL. J. Immunol. 156:3645.
8. Udaka, K., K.-H. Wiesmüller, S. Kienle, G. Jung, and P. Walden. 1995. Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries. J. Exp. Med. 181:2097.
9. Blake, J., J. V. Johnston, K. E. Hellström, H. Marquardt, and L. Chen. 1996. Use of combinatorial libraries to construct functional mimics of tumor epitopes recognized by MHC class I-restricted cytolytic T lymphocytes. J. Exp. Med. 184: 121.
10. Udaka, K., K.-H. Wiesmüller, S. Kienle, G. Jung, and P. Walden. 1996. Self-MHC-restricted peptides recognized by alloreactive T lymphocyte clone. J. Immunol. 157:670.
11. Hemmer, B., B. Fleckenstein, M. Vergelli, G. Jung, H. McFarland, R. Martin, and K. H. Wiesmueller. 1997. Identification of high potency microbial and self ligands for a human autoreactive class II restricted T cell clone. J. Exp. Med. 185:1651.
12. + T cell epitopes with dedicated synthetic peptide libraries. Proc. Natl. Acad. Sci. USA 94:10313.
13. Hemmer, B., C. Pinilla, J. Appel, J. Pascal, R. Houghten, and R. Martin. 1998. The use of soluble synthetic peptide combinatorial libraries to determine antigen recognition of T cells. J. Pept. Res. 52:338.
14. Hiemstra, H. S., P. A. van Veelen, N. C. Schloot, A. Geluk, K. E. van Meijgaarden, S. J. Willemen, J. A. Leunissen, W. E. Benckhuijsen, R. Amons, R. R. de Vries, et al. 1998. Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries. J. Immunol. 161:4078.
15. + T cells and induce T cell responses to native peptide ligands. J. Immunol. 163:6424.
16. Pinilla, C., J. R. Appel, P. Blanc, and R. A. Houghten. 1992. Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries. BioTechniques 13:901.
17. Pinilla, C., J. R. Appel, and R. A. Houghten. 1994. Investigation of antigen-antibody interactions using a soluble nonsupport-bound synthetic decapeptide library composed of four trillion sequences. Biochem. J. 301:847.
18. Houghten, R. A. 1985. General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual ammo acids. Proc. Natl. Acad. Sci. USA 82:847.
19. Ostresh, J. M., J. H. Winkle, V. T. Hamashin, and R. A. Houghten. 1994. Peptide libraries: Determination of relative reaction rales of protected amino acids in competitive couplings. Biopolymers 34:1681.
20. Houghten, R. A., C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley, and J. H. Cuervo. 1991. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature 354:84.
21. Ling, N., F. Esch, P. Böhlen, P. Brazeau, W. B. Wehrenberg, and R. Guillemin. 1984. Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor. Proc. Natl. Acad. Sci. USA 81:4302.
22. Vergelli, M., B. Hemmer, U. Utz, A. Vogt, M. Kalbus, L. Tranquill, P. Conlon, N. Ling, L. Steinman, H. F. McFarland, and R. Martin. 1996. Differential T cell activation by altered peptide ligands derived from myclin basic protein peptide (87-99). Eur. J. Immunol. 26:2624.
23. Maillere, B., G. Mourier, M. Herve, and A. Menez. 1995. Fine chemical modilications at N- and C-termini enhance peptide presentation to T cells by increasing the life span of both free and MHC-complexed peptides. Mol. Immunol. 32:1377.
24. Hemmer, B., M. Vergelli, B. Gran, N. Ling, C. Pinilla, R. Houghten, P. Conlon, H. F. McFarland, and R. Martin. 1998. Cutting edge: predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology. J. Immunol. 160:3631.
25. Vogt, A. B., H. Kropshofer, H. Kalbacher, M. Kalbus, H.-G. Rammensee, J. E. Coligan, and R. Martin. 1994. Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides. J. Immunol. 153:1665.
26. Wucherpfennig, K. W., A. Sette, S. Southwood, C. Oseroff, M. Matsui, J. L. Strominger, and D. A. Hafler. 1994. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179:279.
27. Valli, A., A. Sette, L. Kappos, C. Oseroff, J. Sidney, G. Miescher, M. Hochberger, E. D. Albert, and L. Adorini. 1993. Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients. J. Clin. Invest. 91:616.
28. Madrenas, J., R. L. Wange, J. L. Wang, N. Isakov, L. Samelson, and R. N. Germain. 1995. ζ Phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 167:515.
29. Gundlach, B. R., K. H. Wiesmuller, T. Junt, S. Kienle, G. Jung, and P. Walden. 1996. Determination of T cell epitopes with random peptide libraries. J. Immunol. Methods 192:149.
30. Vergelli, M., B. Hemmer, M. Kalbus, A. Vogt, N. Ling, P. Conlon, J. E. Coligan, H. F. McFarland, and R. Martin. 1997. Modifications of peptide ligands enhancing T cell responsiveness imply large numbers of stimulatory ligands for autoreactive T cells. J. Immunol. 158:3746.
31. Janeway, C. A. 1995. Ligands for the T-cell receptor: hard times for avidity models. Immunol. Today 16:223.
32. Jameson, S. C., and M. J. Bevan. 1995. T cell receptor antagonists and partial agonists. Immunity 2:1.
33. Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
34. Davis, M. M., J. J. Boniface, Z. Reich, D. Lyons, J. Hampl. B. Arden, and Y. Chien. 1998. Ligand recognition by αβ T cell receptors. Annu. Rev. Immunol. 16:523.
35. Mason, D. 1998. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19:395.
36. Kersh, G. J., E. N. Kersh, D. H. Fremont, and P. M. Allen. 1998. High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling. Immunity 9:817.
37. De Magistris M. T., J. Alexander, M. Coggeshall, A. Altman, F. C. Gaeta, H. M. Grey, and A. Sette. 1992. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68:625.
38. Lyons, D. S., S. A. Lieberman, J. Hampl, J. J. Boniface, Y.-h. Chien, L. I. Berg, and M. M. Davis. 1996. A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than agonists. Immunity 5:53.
39. Kisielow, P., and H. von Boehmer. 1995 Development and selection of T cells: facts and puzzles. Adv. Immunol. 58:87.
40. + T cells, but affect their long-term life span. Immunity 5:217.
41. Tanchot, C.,F. A. Lemonnier, B. Perarnau, A. A. Freitas, and B. Rocha. 1997. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276:2057.
42. Garcia, K. C., M. Degano, L. R.Pease, M. Huang, P. A. Peterson, L. Teyton, and I. A. Wilson. 199S. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science 279:1166.
43. Garcia, K. C., M. Degano, R. L. Stanfield, A. Brunmark, M. R. Jackson, P. A. Peterson, L. Teyton, and I. A. Wilson. 1996. An α/β T cell receptor structure at 2. 5 A and its orientation in the TCR-MHC complex. Science 274:209.
44. Ding, Y. H., K. J. Smith, D. N. Garboczi, U. Utz, W. E. Biddison, and D. C. Wiley. 1998. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8:403.
45. Garboczi, D. N., U. U., P. Ghosh, A. Seth, J. Kim, E. A. VanTienhoven, W. E. Biddison, and D. C. Wiley. 1996. Assembly, specific binding, and crystallization of a human TCR-αβ with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2. J. Immunol. 157:5403.
46. Pinilla, C., R. Martin, B. Gran, J. R. Appel, C. Boggiano, D. B. Wilson, and R. A. Houghten. 1999. Exploring immunological specificity using synthetic peptide combinatorial libraries. Curr. Opin. Immunol. 11:193.
47. Smith, P. A., A. Brunmark, M. R. Jackson, and T. A. Potter. 1997. Peptide-independent recognition by alloreactive cytotoxic T lymphocytes (CTL). J. Exp. Med. 185:1023.
48. + T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide. J. Exp. Med. 189:883.
49. Zerrahn, J., W. Held, and D. H. Raulet. 1997. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88:627.
50. Germain, R. N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76:287.
51. Ausubel, L. J., C. K. Kwan, A. Sette, V. Kuchroo, and D. A. Hafler. 1996. Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones. Proc. Natl. Acad. Sci. USA 93:15317.
52. Leggatt, G. R., A. Hosmalin, C. D. Pendleton, A. Kumar, S. Hoffman, and J. A. Berzofsky. 1998. The importance of pairwise interactions between peptide residues in the delineation of TCR specificity. J. Immunol. 161:4728.
53. Pinilla, C., S. Chendra, J. R. Appel, and R. A. Houghten. 1995 Elucidation of monoclonal antibody polyspecificity using a synthetic combinatorial library. Pept. Res. 8:250.
54. Appel, J. R., S. Muller, N. Benkirane, R. A. Houghten, and C. Pinilla. 1996. Highly specific, cross-reactive sequences recognized by an anti-HBsAg antibody identified from a positional scanning synthetic combinatorial library. Pept. Res. 9:174.
55. Bhardwaj, V., V. Kumar, H. M. Geysen, and E. B. Sercarz. 1993. Degenerate-recognition of a dissimilar antigenic peptide by mylein-basic protein-reactive T cells. J. Immunol. 151:5000.