Modifications of Peptide Ligands Enhancing T Cell Responsiveness Imply Large Numbers of Stimulatory Ligands for Autoreactive T Cells

Journal of Immunology

Volumn 158, Issue 8, 1997, Pages 3746-3752

  Vergelli, Marco ^a   Hemmer, Bernhard ^a   Kalbus, Matthias ^b   Vogt, Anne B ^c   Ling, Nick ^d   Conlon, Paul ^d   Coligan, John E ^e   McFarland, Henry ^a   Martin, Roland ^a,b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d NEUROCRINE BIOSCIENCES INC   (United States)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGAND; PEPTIDE;

AMINO ACID SEQUENCE; ARTICLE; DRUG EFFECT; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MOLECULAR GENETICS; T LYMPHOCYTE;

AMINO ACID SEQUENCE; HUMANS; LIGANDS; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; PEPTIDES; T-LYMPHOCYTES;

EID: 0031569454     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol. Today 14:602.
2. Sloan-Lancaster, J., and P. M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1.
3. Kersh, G. J., and P. M. Allen. 1996. Essential flexibility in the T cell recognition of antigen. Nature 380:495.
4. Evavold, B. D., and P. M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
5. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T-cell anergy by altered T cell receptor ligand on live antigen-presenting cells. Nature 363:156.
6. Evavold, B. D., J. Sloan-Lancaster, B. L. Hsu, and P. M. Allen. 1993. Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 150:3131.
7. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling: Altered phospho-ζ and lack of zap70 recruitment in APL-induced T cell anergy. Cell 79:913.
8. De Magistris, M. T., J. Alexander, M. Coggeshall, A. Altman, F. C. A. Gaeta, H. M. Grey, and A. Sette. 1992. Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68:625.
9. Racioppi, L., F. Ronchese, L. A. Matis, and R. N. Germain. 1993. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J. Exp. Med. 177:1047.
10. Evavold, B. D., J. Sloan-Lancaster, K. J. Wilson, J. B. Rothbard, and P. M. Allen. 1995. Specific T cell recognition of minimally homologous peptides: evidence for endogenous ligands. Immunity 2:655.
11. Deibler, G. E., R. E. Martenson, and M. W. Kies. 1972. Large scale preparation of myelin basic protein from central nervous system tissue of several mammalian species. Prep. Biochem. 2:139.
12. Ling, N., F. Esch, P. Böhlen, P. Brazeau, W. B. Wehrenberg, and R. Guillemin. 1984. Isolation, primary structure, and synthesis of human hypothalamic somatocrinin: growth hormone-releasing factor. Proc. Natl. Acad. Sci. USA 81:4302.
13. Vogt, A. B., H. Kropshofer, H. Kalbacher, M. Kalbus, H.-G. Rammensee, J. E. Coligan, and R. Martin. 1994. Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides. J. Immunol. 153:1665.
14. + cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J Immunol. 148:1359.
15. + cytotoxic T lymphocytes from patients with HTLV-1-associated disease: evidence for oligoclonal expansion. J. Virol. 70:843.
16. Wucherpfennig, K. W., A. Sette, S. Southwood, C. Oseroff, M. Matsui, J. L. Strominger, and D. A. Hafler. 1994. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179:279.
17. Hammer, J., E. Bono, F. Gallazzi, C. Belunis, Z. Nagy, and F. Sinigaglia. 1994. Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning. J. Exp. Med. 180:2353.
18. Fujinami, R. S., and M. B. A. Oldstone. 1985. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230:1043.
19. Wraith, D. C., B. Brunn, and P. J. Fairchild. 1992. Cross-reactive antigen recognition by an encephalitogenic T cell receptor: implication for T cell biology and autoimmunity. J. Immunol. 149:3765.
20. Cao, W., B. A. Myers-Powell, and T. J. Braciale. 1994. Recognition of an immunoglobulin VH epitope by influenza virus-specific class I major histocompatibility complex-restricted cytotoxic T lymphocytes. J. Exp. Med. 179:195.
21. Luo, A.-M., K. M. Garza, D. Hunt, and K. S. K. Tung. 1993. Antigen mimicry in autoimmune disease: sharing of amino acid residues critical for pathogenic T cell activation. J. Clin. Invest. 92:2117.
22. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.