Homozygous deletion of the PTEN tumor suppressor gene in a subset of prostate adenocarcinomas

Clinical Cancer Research

Volumn 4, Issue 3, 1998, Pages 811-815

  Wang, Steven I ^a   Parsons, Ramon ^a   Ittmann, Michael ^b  

^a Depts of Pathology and Medicine College of Physicians and Surgeons Columbia University ^*  (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MICROSATELLITE DNA; PHOSPHOPROTEIN PHOSPHATASE;

ALLELE; ARTICLE; CANCER CELL CULTURE; CHROMOSOME 10Q; CONTROLLED STUDY; COWDEN SYNDROME; DNA PROBE; ENZYME SPECIFICITY; EXON; GENE DELETION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATECTOMY; PTEN GENE; SOUTHERN BLOTTING; TUMOR SUPPRESSOR GENE;

EID: 0031922369     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Visakorpi, T., Kallioniemi, A., Hyytinen, E., Karhu, R., Tammela, T., Isola, J., and Kallioniemi, O. Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization. Cancer Res., 55: 342-347, 1995.
2. Ittmann, M. Allelic loss on chromosome 10 in prostate adenocarcinomas. Cancer Res., 56: 2143-2147, 1996.
3. Gray, I., Phillips, S., Lee, S., Neoptolemos, J., Weissenbach, J., and Spurr, N. Loss of the chromosomal region 10q23-25 in prostate cancer. Cancer Res., 55: 4800-4803, 1995.
4. Komiya, A., Suzuki, H., Ueda, T., Emi, M., Ito, H., and Shimazaki, J. Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer. Genes Chromosomes Cancer, 17: 245-253, 1996.
5. Trybus, T., Burgess, A., Wojno, K., Glover, T., and Macoska, J. Distinct areas of allelic loss on chromosomal regions 10p and 10q in human prostate cancer. Cancer Res., 56: 2263-2267, 1996.
6. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S., Giovanella, B., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M., and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (Washington DC), 274: 1943-1947, 1997.
7. Singh, B., Ittmann, M., and Krolewski, J. Sporadic breast cancers exhibit loss of heterozygosity on chromosome 10q23 at the locus lost in Cowden disease. Genes Chromosomes Cancer, in press, 1998.
8. Steck, P., Pershouse, M., Jasser, S., Yung, A., Lin, H., Ligon, A., Langford, L., Baumgard, M., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D., and Tavtigian, S. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15: 356-362, 1997.
9. Cappellen, D., Diez de Medina, G., Thiery, J., and Radvanyi, F. Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder. Oncogene, 14: 3059-3066, 1997.
10. Peiffer, S., Herzog, T., Tribune, D., Mutch, D., Gersell, D., and Goodfellow, P. Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers. Cancer Res., 55: 1922-1926, 1995.
11. Petersen, I., Langreck, H., Wolf, G., Schwandel, A., Psille, R., Vogt, P., Reichel, M., Ried, T., and Dietel, M. Small-cell lung cancer is characterized by a high incidence of deletions on chromosome 3p, 4q, 5q, 10q, 13q and 17p. Br. J. Cancer, 75: 79-86, 1997.
12. Herbst, R., Weiss, J., Ehnis, A., Cavanee, W., and Arden, K. Loss of heterozygosity for 10q22-10qter in malignant melanoma progression. Cancer Res., 54: 3111-3114, 1994.
13. Karlbom, A., James, C., Boethius, J., Cavenee, W., Collins, V., Nordenskjold, M., and Lasson, C. Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10. Hum. Genet., 92: 169-174, 1993.
14. Fults, D., Brockmeyer, D., Tullous, M., Pedone, C., and Cawthon, R. p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression. Cancer Res., 52: 674-679, 1992.
15. Wang, S. I., Puc, J., Li, J., Bruce, J., Cairns, P., Sidransky, D., and Parsons, R. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res., 57: 4183-4186, 1997.
16. Myers, M., Stolarov, J., Eng, C., Li, J., Wang, S. I., Wigler, M., Parsons, R., and Tonks, N. P-TEN, the tumor suppressor from chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci. USA, 94: 9052-9057, 1997.
17. Liaw, D., Marsh, D., Li, J., Dahia, P., Wang, S. I., Zheng, Z., Bose, S., Call, K., Tsou, H., Peacock, M., Eng, C., and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast-thyroid cancer syndrome. Nat. Genet., 16: 64-67, 1997.
18. Krolewski, J., Lee, R., Eddy, R., Shows, T., and Dalla-Favera, R. Identification and chromosomal mapping of new human tyrosine kinase genes. Oncogene, 5: 277-282, 1990.
19. Cairns, P., Tokino, K., Eby, Y., and Sidransky, D. Homozygous deletions of 9p21 in primary human bladder tumors detected by comparative multiplex polymerase chain reaction. Cancer Res., 54: 1422-1424, 1994.
20. Rempel, S., Schwechheimer, K., Davis, R., Cavenee, W., and Rosenblum, M. Loss of heterozygosity for loci on chromosome 10 is associated with morphologically malignant meningioma progression. Cancer Res., 53: 2386-2392, 1993.
21. Cairns, P., Okami, K., Halachmi, N., Esteller, M., Herman, J., Jen, J., Issacs, W., Bova, S., and Sidransky, D. Frequent inactivation on PTEN/MMAC1 in primary prostate cancer. Cancer Res., 57: 4997-5000, 1997.